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公开(公告)号:US20090291914A1
公开(公告)日:2009-11-26
申请号:US12472479
申请日:2009-05-27
申请人: Akira ASARI , Hitoshi KURIHARA , Tomomi SHIBATA , Yuka MIYAZAKI , Hiroko YAMANOKUCHI , Akira TAWADA , Takahiro MASA , Yuji MATSUZAKI
发明人: Akira ASARI , Hitoshi KURIHARA , Tomomi SHIBATA , Yuka MIYAZAKI , Hiroko YAMANOKUCHI , Akira TAWADA , Takahiro MASA , Yuji MATSUZAKI
IPC分类号: A61K31/728 , A61P1/16 , A61P1/04
CPC分类号: C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要: A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译: 用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示,通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分,或通过施用有效量的分离和基本上纯的本申请中描述的式(1)四糖。 保存器官的方法