公开(公告)号：US09254243B2

公开(公告)日：2016-02-09

申请号：US14008808

申请日：2012-03-14

申请人： Akira Higuchi ,  Akinobu Okuda ,  Akihiro Ohta ,  Yuki Takenaka ,  Tohru Nakamura

发明人： Akira Higuchi ,  Akinobu Okuda ,  Akihiro Ohta ,  Yuki Takenaka ,  Tohru Nakamura

IPC分类号： A61J1/20 ,  A61M5/162

CPC分类号： A61J1/2096 ,  A61M5/162

摘要： A drug transferring needle includes a needle base portion, a first needle portion having therein an air passage, and a second needle portion longer than the first needle portion and arranged parallel to the first needle portion. In the first needle portion, a first air vent being one end of the air passage is provided on a distal end side of the second needle portion from a second air vent being the other end of the air passage. In the second needle portion, one end of a liquid passage is connected to the inside of the needle base portion, and the other end thereof is a liquid pass opening of the second needle portion. The second needle portion has a distal end having the liquid pass opening, a base portion connected to the needle base portion, and an intermediate portion connecting the distal end and the base portion.

摘要翻译： 药物传送针包括针基部，其中具有空气通道的第一针部分和比第一针部长并且平行于第一针部分布置的第二针部分。 在第一针部中，作为空气通路的另一端的第二排气口在第二针部的前端侧设置有作为空气通路一端的第一排气口。 在第二针部中，液体通路的一端与针基部的内侧连接，另一端为第二针部的液体通过口。 第二针部具有具有液体通过口的远端，与针基部连接的基部，以及连接前端和基部的中间部。

公开(公告)号：US20140230952A1

公开(公告)日：2014-08-21

申请号：US14008808

申请日：2012-03-14

申请人： Akira Higuchi ,  Akinobu Okuda ,  Akihiro Ohta ,  Yuki Takenaka ,  Tohru Nakamura

发明人： Akira Higuchi ,  Akinobu Okuda ,  Akihiro Ohta ,  Yuki Takenaka ,  Tohru Nakamura

IPC分类号： A61J1/20

CPC分类号： A61J1/2096 ,  A61M5/162

摘要： A drug transferring needle includes a needle base portion, a first needle portion having therein an air passage, and a second needle portion longer than the first needle portion and arranged parallel to the first needle portion. In the first needle portion, a first air vent being one end of the air passage is provided on a distal end side of the second needle portion from a second air vent being the other end of the air passage. In the second needle portion, one end of a liquid passage is connected to the inside of the needle base portion, and the other end thereof is a liquid pass opening of the second needle portion. The second needle portion has a distal end having the liquid pass opening, a base portion connected to the needle base portion, and an intermediate portion connecting the distal end and the base portion.

摘要翻译： 药物传送针包括针基部，其中具有空气通道的第一针部分和比第一针部长并且平行于第一针部分布置的第二针部分。 在第一针部中，作为空气通路的另一端的第二排气口在第二针部的前端侧设置有作为空气通路一端的第一排气口。 在第二针部中，液体通路的一端与针基部的内侧连接，另一端为第二针部的液体通过口。 第二针部具有具有液体通过口的远端，与针基部连接的基部，以及连接前端和基部的中间部。

公开(公告)号：US20110250230A1

公开(公告)日：2011-10-13

申请号：US13062999

申请日：2009-09-11

申请人： Hiroshi Shiku ,  Hiroaki Ikeda ,  Jun Mitsui ,  Yuki Takenaka ,  Junichi Mineno ,  Ikunoshin Kato

发明人： Hiroshi Shiku ,  Hiroaki Ikeda ,  Jun Mitsui ,  Yuki Takenaka ,  Junichi Mineno ,  Ikunoshin Kato

IPC分类号： A61K39/00 ,  C12N15/63 ,  A61P35/00 ,  C12N5/10

CPC分类号： A61K39/0005 ,  A61K35/12 ,  A61K38/00 ,  A61K38/191 ,  A61K39/0011 ,  A61K2039/5152 ,  A61K2039/5156 ,  C07K14/70575 ,  C07K2319/30 ,  C12N2799/022 ,  C12N2799/027

摘要： Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.

摘要翻译： 公开了能够表达外源GITRL或外源性GITRL衍生物的细胞; 电池的制造方法; 包含该细胞作为活性成分的治疗或预防剂; 在制造治疗或预防剂中使用细胞; 一种方法，包括将细胞施用于受试者的步骤; 携带编码GITRL或GITRL衍生物的基因的病毒载体; 包含病毒载体作为活性成分的治疗或预防剂; 病毒载体在制备治疗或预防药物中的应用; 以及包括将病毒载体施用于受试者的步骤的方法。

公开(公告)号：US08586023B2

公开(公告)日：2013-11-19

申请号：US13062999

申请日：2009-09-11

申请人： Hiroshi Shiku ,  Hiroaki Ikeda ,  Jun Mitsui ,  Yuki Takenaka ,  Junichi Mineno ,  Ikunoshin Kato

发明人： Hiroshi Shiku ,  Hiroaki Ikeda ,  Jun Mitsui ,  Yuki Takenaka ,  Junichi Mineno ,  Ikunoshin Kato

IPC分类号： A61K48/00

CPC分类号： A61K39/0005 ,  A61K35/12 ,  A61K38/00 ,  A61K38/191 ,  A61K39/0011 ,  A61K2039/5152 ,  A61K2039/5156 ,  C07K14/70575 ,  C07K2319/30 ,  C12N2799/022 ,  C12N2799/027

摘要： Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.