公开(公告)号：US20050287541A1

公开(公告)日：2005-12-29

申请号：US10947249

申请日：2004-09-23

申请人： Akira Nakagawara ,  Miki Ohira ,  Shin Ishii ,  Takeshi Goto ,  Hiroyuki Kubo ,  Takahiro Hirata ,  Yasuko Yoshida ,  Saichi Yamada

发明人： Akira Nakagawara ,  Miki Ohira ,  Shin Ishii ,  Takeshi Goto ,  Hiroyuki Kubo ,  Takahiro Hirata ,  Yasuko Yoshida ,  Saichi Yamada

IPC分类号： C12M1/34 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118

摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of Seq. ID No. 1 to 96 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of Seq. ID No. 97 to 200 or their partial continuous sequences or their complementary strands.

摘要翻译： 一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸 序列Seq。 ID No.1至96或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交并选自104个多核苷酸 由Seq的核苷酸序列组成。 ID号97至200或其部分连续序列或其互补链。

公开(公告)号：US07601532B2

公开(公告)日：2009-10-13

申请号：US10947249

申请日：2004-09-23

申请人： Akira Nakagawara ,  Miki Ohira ,  Shin Ishii ,  Takeshi Goto ,  Hiroyuki Kubo ,  Takahiro Hirata ,  Yasuko Yoshida ,  Saichi Yamada

发明人： Akira Nakagawara ,  Miki Ohira ,  Shin Ishii ,  Takeshi Goto ,  Hiroyuki Kubo ,  Takahiro Hirata ,  Yasuko Yoshida ,  Saichi Yamada

IPC分类号： C12M3/00 ,  C12M1/34 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118

摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 1, 5, 6, 14. 16, 17, 19, 22-24, 28, 29, 31, 37, 39, 40, 43, 44, 47-52, 54, 57-60, 62, 64, 65, 67, 68, 72-75, 77, 78, 80-82, 84, 87, 89-91, 94, 100, 103, 112, 113, 118, 120, 129, 130, 132, 136, 138, 142, 144, 145, 148, 150-153, 155, 158-160, 163-165, 169-171, 173, 174, 177, 178, 180-182, 184, 186, 187, 189, 191, 192, 194, 195, 198-200 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 2-4, 7-13, 15, 18, 20, 21, 25-27, 30, 32-36, 38, 41, 42, 45, 46, 53, 55, 56, 61, 63, 66, 69-71, 76, 79, 83, 85, 86, 88, 92, 93, 95-99, 101, 102, 104-111, 114-117, 119, 121-128, 131, 133-135, 137, 139-141, 143, 146, 147, 149, 154, 156, 157, 161, 162, 166-168, 172, 175, 176, 179, 183, 185, 188, 190, 193, 196, 197 or their partial continuous sequences or their complementary strands.

摘要翻译： 一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸 SEQ。 身份证号 1，5，6，14，16，17，19，22-24，28，29，31，37，39，40，43，44，47-52，54，57-60，62，64，65， 67，68，72-75，77，78，80-82，84，87，89-91，94，100，103，112，113，118，120，129，130，132，136，138， 144,145,148,150-153,155,158-160,163-165,169-171,173,174,177,178,180-182,184,186,187,189,191,192,194， 195，198-200或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交，并且选自104个多核苷酸 的SEQ ID NO： 身份证号 2-4，7-13，15，18，20，21，25-27，30，32-36，38，41，42，45，46，53，55，56，61，63，66，69- 71,76,79,83,85,86,88,92,93,95-99,101,102,104-111,114-117,119,121-128,131,133-135,137,139- 141,143,146,147,149,154,156,157,161,162,166-168,172,175,176,179,183,185,188,190,193,196,197或其部分连续序列 或其互补链。

公开(公告)号：US20070281296A1

公开(公告)日：2007-12-06

申请号：US10533158

申请日：2003-10-30

申请人： Akira Nakagawara ,  Miki Ohira

发明人： Akira Nakagawara ,  Miki Ohira

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Diagnostic agent or kit for the prognosis of neuroblastoma is used to diagnose the prognosis of neuroblastoma (particularly, classifying its progress and determining stage 4s neuroblastoma), which agent or kit comprising a nucleic acid probe, nucleic acid primers, or a nucleic acid microarray utilizing a nucleic acid comprising one sequence selected from the group consisting of nucleic acids set forth in SEQ ID NO:1 to SEQ ID NO:174, a fragment thereof, or a combination of either or both.

摘要翻译： 用于神经母细胞瘤预后的诊断剂或试剂盒用于诊断神经母细胞瘤的预后（特别是对其进展进行分类并确定阶段4s神经母细胞瘤），所述试剂或试剂盒包含核酸探针，核酸引物或核酸微阵列，其利用 包含选自SEQ ID NO：1至SEQ ID NO：174所示核酸的一个序列的核酸，其片段，或其中任一者或两者的组合。

公开(公告)号：US07429451B2

公开(公告)日：2008-09-30

申请号：US10533158

申请日：2003-10-30

申请人： Akira Nakagawara ,  Miki Ohira

发明人： Akira Nakagawara ,  Miki Ohira

IPC分类号： C12Q1/68 ,  C07H21/02

CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Diagnostic agent or kit for the prognosis of neuroblastoma is used to diagnose the prognosis of neuroblastoma (particularly, classifying its progress and determining stage 4s neuroblastoma), which agent or kit comprising a nucleic acid probe, nucleic acid primers, or a nucleic acid microarray utilizing a nucleic acid comprising one sequence selected from the group consisting of nucleic acids set forth in SEQ ID NO:1 to SEQ ID NO:174, a fragment thereof, or a combination of either or both.

摘要翻译： 用于神经母细胞瘤预后的诊断剂或试剂盒用于诊断神经母细胞瘤的预后（特别是对其进展进行分类并确定阶段4s神经母细胞瘤），所述试剂或试剂盒包含核酸探针，核酸引物或核酸微阵列，其利用 包含选自SEQ ID NO：1至SEQ ID NO：174所示核酸的一个序列的核酸，其片段，或其中任一者或两者的组合。