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    Use of GLP-1 and agonists thereof to prevent cardiac myocyte apoptosis
    2.
    发明申请
    Use of GLP-1 and agonists thereof to prevent cardiac myocyte apoptosis 审中-公开
    使用GLP-1及其激动剂来预防心肌细胞凋亡

    公开(公告)号：US20070021336A1

    公开(公告)日：2007-01-25

    申请号：US11313763

    申请日：2005-12-22

    申请人： Christen Anderson ,  Alain Baron

    发明人： Christen Anderson ,  Alain Baron

    IPC分类号： A61K38/26

    CPC分类号： A61K38/26

    摘要： The present invention relates generally to the novel use of GLP-1, including analogs, and agonists, to prevent cardiac myocyte apoptosis. The present invention relates to methods for using GLP-1 for the treatment of conditions associated with cardiac myocyte apoptosis. The present invention further relates to improving the efficiency of cardiac myocytes and also to improving cardiac contractility.

    摘要翻译： 本发明一般涉及GLP-1（包括类似物和激动剂）在预防心肌细胞凋亡中的新用途。 本发明涉及使用GLP-1用于治疗与心肌细胞凋亡相关的病症的方法。 本发明还涉及提高心肌细胞的效率和改善心肌收缩力。

    Blowing device comprising a nozzle and a supply duct forming an obtuse angle
    5.
    发明授权
    Blowing device comprising a nozzle and a supply duct forming an obtuse angle 有权
    发泡装置包括形成钝角的喷嘴和供给管道

    公开(公告)号：US09114560B2

    公开(公告)日：2015-08-25

    申请号：US14359136

    申请日：2012-11-28

    申请人： Alain Baron ,  Frederic Lecomte ,  Cedric Lemaire

    发明人： Alain Baron ,  Frederic Lecomte ,  Cedric Lemaire

    IPC分类号： B29C49/58 ,  B29C49/12 ,  B29D22/00

    CPC分类号： B29C49/12 ,  B29C49/58 ,  B29D22/003

    摘要： Disclosed is a blowing device (10) for forming containers (24) from thermoplastic material preforms. The device (10) includes a blowing nozzle (12) including a bottom outlet opening (28) for a pressurized blowing fluid to leave along a vertical outlet axis (28) and a single duct (14) for supplying the nozzle (12) with blowing fluid that leads into the nozzle (12), via a top supply opening (31), along an axis that is completely radial relative to the outlet axis (A2) of the nozzle (12). The blowing device is characterized in that the upstream end section of the supply duct (14) leads into the nozzle (12) along a branching axis (B) that forms an obtuse angle (a) with the outlet axis (A1) of the nozzle (12) such that the blowing fluid leaving the supply duct (14) is directed downward.

    摘要翻译： 公开了一种用于从热塑性材料预制件形成容器（24）的吹风装置（10）。 该设备（10）包括一个吹风喷嘴（12），该吹风喷嘴包括一个底部出口开口（28），用于加压发泡流体沿垂直出口轴线（28）离开，而单个管道（14）用于将喷嘴（12） 通过顶部供应开口（31）沿着相对于喷嘴（12）的出口轴线（A2）完全径向的轴线吹送通向喷嘴（12）的流体。 吹送装置的特征在于，供给管道（14）的上游端部分沿着与喷嘴的出口轴线（A1）形成钝角（a）的分支轴线（B）引入喷嘴（12） （12），使得离开供应管道（14）的吹送流体向下指向。

    Compositions for the Treatment and Prevention of Nephropathy
    6.
    发明申请
    Compositions for the Treatment and Prevention of Nephropathy 审中-公开
    治疗和预防肾病的组成

    公开(公告)号：US20090203603A1

    公开(公告)日：2009-08-13

    申请号：US12338887

    申请日：2008-12-18

    申请人： Alain Baron ,  David R. Hathaway ,  Mahesh Mistry ,  Richard J. Roman

    发明人： Alain Baron ,  David R. Hathaway ,  Mahesh Mistry ,  Richard J. Roman

    IPC分类号： A61K38/00

    CPC分类号： A61K38/26

    摘要： Compositions and methods for the prevention and treatment of nephropathy, including hypertensive and diabetic nephropathy, and nephropathy associated with insulin resistance and metabolic syndrome are described. Compositions of the invention include a compound that binds to a receptor for the glucagon like peptide-1, an incretin, a glucagon-like peptide-1 (GLP-1), an exendin, or an analog (including an agonist analog), derivative, or variant of any of them.

    摘要翻译： 描述了预防和治疗肾病，包括高血压和糖尿病肾病以及与胰岛素抵抗和代谢综合征相关的肾病的组合物和方法。 本发明的组合物包括与胰高血糖素样肽-1，肠降血糖素，胰高血糖素样肽-1（GLP-1），毒蜥外泌肽或类似物（包括激动剂类似物）衍生物的受体结合的化合物 ，或其任何变体。