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1.发明申请Methods for Treating or Ameliorating Ghrelin-Associated Diseases and Disorders 审中-公开治疗或改善Ghrelin相关疾病和疾病的方法公开(公告)号：US20070275877A1
公开(公告)日：2007-11-29
申请号：US10569771
申请日：2004-08-30
申请人： Alain Baron , Andrew Young , Bronislava Gedulin
发明人： Alain Baron , Andrew Young , Bronislava Gedulin
CPC分类号： A61K38/2278 , A61K31/64 , A61K31/7004 , A61K38/22 , A61K38/26 , A61K38/28 , A61K2300/00
摘要： Methods for modulating the effective levels of ghrelin are disclosed. These methods include the use of amylin, amylin agonists and amylin antagonists to regulate the effective levels of ghrelin. Methods for the prevention, treatment, or amelioration of ghrelin-associated diseases or disorders utilizing the methods for modulating ghrelin are also disclosed.
摘要翻译： 公开了调节生长素释放肽有效水平的方法。 这些方法包括使用胰岛淀粉样多肽，胰岛淀粉样多肽激动剂和胰岛淀粉样多肽拮抗剂来调节生长素释放肽的有效水平。 还公开了利用调节生长素释放肽的方法预防，治疗或改善生长素释放肽相关疾病或病症的方法。
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公开(公告)号：US20070037750A1
公开(公告)日：2007-02-15
申请号：US11584114
申请日：2006-10-19
申请人： Andrew Young , Bronislava Gedulin
发明人： Andrew Young , Bronislava Gedulin
IPC分类号： A61K38/22
CPC分类号： C07K14/57563 , A61K38/00 , A61K47/60
摘要： Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, for lowering glucagon levels and/or suppressing glucagon secretion in a subject are provided. These methods are are useful in treating hyperglucagonemia and other conditions that would be benefited by lowering plasma glucgon or suppressing glucagon secretion.
摘要翻译： 使用与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素，例如降低胰高血糖素水平和/或抑制受试者中胰高血糖素分泌的毒蜥外泌肽，毒蜥外泌肽激动剂或经修饰的毒蜥外泌肽或毒蜥外泌肽激素的方法是： 提供。 这些方法可用于治疗高胰高血糖素血症和通过降低血浆胰高血糖素或抑制胰高血糖素分泌而受益的其它病症。
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公开(公告)号：US20050215469A1
公开(公告)日：2005-09-29
申请号：US10894999
申请日：2004-07-19
IPC分类号： A61K45/00 , A61K35/56 , A61K38/00 , A61K38/17 , A61K38/22 , A61K38/23 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , C07K14/575
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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公开(公告)号：US07297761B2
公开(公告)日：2007-11-20
申请号：US10894999
申请日：2004-07-19
申请人： Nigel Robert Arnold Beeley , Kathryn S. Prickett , Sunil Bhavsar , Andrew Young , Bronislava Gedulin
发明人： Nigel Robert Arnold Beeley , Kathryn S. Prickett , Sunil Bhavsar , Andrew Young , Bronislava Gedulin
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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公开(公告)号：US20050171019A1
公开(公告)日：2005-08-04
申请号：US11083730
申请日：2005-03-18
申请人： Andrew Young , Bronislava Gedulin
发明人： Andrew Young , Bronislava Gedulin
IPC分类号： A61K47/48 , A61K20060101 , A61K38/00 , A61K38/02 , A61K38/22 , A61K38/26 , A61K45/00 , A61P5/00 , A61P5/48 , A61P17/00 , A61P35/00 , C07K14/435 , C07K14/575
CPC分类号： C07K14/57563 , A61K38/00 , A61K47/60
摘要： Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, for lowering glucagon levels and/or suppressing glucagon secretion in a subject are provided. These methods are are useful in treating hyperglucagonemia and other conditions that would be benefited by lowering plasma glucgon or suppressing glucagon secretion.
摘要翻译： 使用与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素，例如降低胰高血糖素水平和/或抑制受试者中胰高血糖素分泌的毒蜥外泌肽，毒蜥外泌肽激动剂或经修饰的毒蜥外泌肽或毒蜥外泌肽激素的方法是： 提供。 这些方法可用于治疗高胰高血糖素血症和通过降低血浆胰高血糖素或抑制胰高血糖素分泌而受益的其它病症。
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6.发明申请Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof 审中-公开使用pyy或其激动剂预防和/或治疗炎症性肠病公开(公告)号：US20060122106A1
公开(公告)日：2006-06-08
申请号：US10518128
申请日：2003-06-13
IPC分类号： A61K38/22 , A61K39/395 , A61K31/5377
CPC分类号： G01N33/5082 , A61K31/5377 , A61K38/00 , A61K38/2066 , A61K38/2073 , C07K14/575 , G01N2500/00 , A61K2300/00
摘要： A novel use of PYY or a PYY agonist is disclosed for treating a bowel condition such as inflammatory bowel disease (e.g. ulcerative colitis and Crohn's disease), bowel atrophy, loss of bowel mucosa and loss of bowel mucosal function. The novel use is based on the discovery and demonstration that administration of PYY or a PYY agonist to an animal can protect the colon from injury induced by a hapten known to induce colitis.
摘要翻译： 公开了PYY或PYY激动剂的新用途，用于治疗诸如炎性肠病（例如溃疡性结肠炎和克罗恩病），肠萎缩，肠粘膜损失和肠粘膜功能丧失等肠状况。 该新用途基于发现和证明，PYY或PYY激动剂对动物的施用可以保护结肠免受已知诱导结肠炎的半抗原诱导的损伤。
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公开(公告)号：US20050070472A1
公开(公告)日：2005-03-31
申请号：US10671304
申请日：2003-09-24
申请人： Bronislava Gedulin , Andrew Young
发明人： Bronislava Gedulin , Andrew Young
IPC分类号： A61K20060101 , A61K38/00 , A61K38/17 , A61K38/22
CPC分类号： A61K38/22
摘要： The disclosed invention provides for the treatment of pancreatitis, and the alleviation of pain associated therewith, with amylin, amylin agonists and amylin analogs.
摘要翻译： 所公开的发明提供胰岛淀粉样多肽，胰岛淀粉样多肽激动剂和胰岛淀粉样多肽类似物治疗胰腺炎和与之相关的疼痛的缓解。
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公开(公告)号：US20050043238A1
公开(公告)日：2005-02-24
申请号：US10895909
申请日：2004-07-20
申请人： Andrew Young , Sunil Bhavsar , Bronislava Gedulin
发明人： Andrew Young , Sunil Bhavsar , Bronislava Gedulin
IPC分类号： A61K45/00 , A61K35/56 , A61K38/00 , A61K38/17 , A61K38/22 , A61K38/23 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , C07K14/575
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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9.发明申请公开(公告)号：US20130059807A1
公开(公告)日：2013-03-07
申请号：US13402819
申请日：2012-02-22
IPC分类号： A61K31/554 , A61K31/38 , A61K31/575 , A61K31/506 , A61K31/56 , A61K31/4453 , A61K31/454 , A61K31/40 , A61K31/495 , A61K31/5377 , A61K31/155 , A61K31/4995 , A61K31/7048 , A61P1/04 , A61P3/10 , A61P3/04 , A61P29/00 , A61K31/439
CPC分类号： A61K31/496 , A61K9/0031 , A61K9/02 , A61K9/286 , A61K31/155 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/191 , A61K31/216 , A61K31/38 , A61K31/40 , A61K31/42 , A61K31/452 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/4995 , A61K31/513 , A61K31/5377 , A61K31/55 , A61K31/554 , A61K31/575 , A61K31/655 , A61K31/7042 , A61K45/06 , C07C279/14 , C07D295/13 , C07D401/12 , A61K2300/00
摘要： Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.
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公开(公告)号：US20130023470A1
公开(公告)日：2013-01-24
申请号：US13618922
申请日：2012-09-14
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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