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公开(公告)号：US20050234097A1
公开(公告)日：2005-10-20
申请号：US11083265
申请日：2005-03-16
申请人： Alan Brown , Charlotte Lane , Paul Glossop , David Price , Russell Lewthwaite , Mark Bunnage , Kim James , Graham Lunn
发明人： Alan Brown , Charlotte Lane , Paul Glossop , David Price , Russell Lewthwaite , Mark Bunnage , Kim James , Graham Lunn
IPC分类号： A61K31/138 , A61K31/4035 , A61K31/47
CPC分类号： C07D217/06 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36 , C07C311/46 , C07C323/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2603/74 , C07D213/40 , C07D235/14 , C07D239/26 , C07D295/088 , C07D295/13 , C07D295/26
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050215590A1
公开(公告)日：2005-09-29
申请号：US11086035
申请日：2005-03-21
申请人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
发明人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
IPC分类号： A61K31/165 , A61K31/4035 , A61K31/404 , A61K31/4353 , A61K31/44 , A61K31/445 , A61P11/06 , C07C217/60 , C07C233/43 , C07C237/20 , C07C237/24 , C07C237/30 , C07C237/32 , C07C311/46 , C07C317/32 , C07C323/41 , C07C323/42 , C07D209/04 , C07D211/06 , C07D213/40 , C07D215/16 , C07D217/06 , C07D217/16 , C07D221/24 , C07D295/192 , C07D335/02
CPC分类号： C07C237/20 , C07C237/30 , C07C237/32 , C07C255/60 , C07C311/37 , C07C311/46 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D209/48 , C07D211/32 , C07D213/38 , C07D213/40 , C07D217/06 , C07D217/16 , C07D221/22 , C07D221/24 , C07D295/192 , C07D335/02
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050215542A1
公开(公告)日：2005-09-29
申请号：US11086036
申请日：2005-03-21
申请人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
发明人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
IPC分类号： A61K31/4439 , A61K31/4545 , A61K31/4747 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D213/65 , C07D401/12 , C07D413/02 , C07D43/02
CPC分类号： C07D401/12 , C07D213/65
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds of the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050222128A1
公开(公告)日：2005-10-06
申请号：US11086132
申请日：2005-03-21
申请人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
发明人： Alan Brown , Mark Bunnage , Charlotte Lane , Russell Lewthwaite , Paul Glossop , Kim James , David Price
IPC分类号： A61K31/165 , A61K31/401 , A61K31/4035 , A61K31/4747 , A61K31/495 , A61K31/537 , A61K31/551
CPC分类号： C07C237/20 , C07C237/30 , C07C255/60 , C07C311/46 , C07C323/41 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D211/58 , C07D213/40 , C07D213/75 , C07D217/06 , C07D231/40 , C07D413/04
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US20050085526A1
公开(公告)日：2005-04-21
申请号：US10959934
申请日：2004-10-05
申请人： Alan Brown , Justin Bryans , Mark Bunnage , Paul Glossop , Charlotte Lane , Russell Lewthwaite , Simon Mantell
发明人： Alan Brown , Justin Bryans , Mark Bunnage , Paul Glossop , Charlotte Lane , Russell Lewthwaite , Simon Mantell
IPC分类号： C07D209/42 , A61K31/405
CPC分类号： C07D209/42
摘要： The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
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公开(公告)号：US20050014763A1
公开(公告)日：2005-01-20
申请号：US10860772
申请日：2004-06-03
申请人： Alan Brown , Charlotte Lane , Russell Lewthwaite
发明人： Alan Brown , Charlotte Lane , Russell Lewthwaite
IPC分类号： A61K31/4439 , A61K31/4709 , A61K31/496 , C07
CPC分类号： A61K31/4709 , A61K31/4439 , A61K31/496 , C07D213/73 , C07D401/04 , C07D401/12
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
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公开(公告)号：US20060035922A1
公开(公告)日：2006-02-16
申请号：US11201823
申请日：2005-08-10
IPC分类号： A61K31/4745 , C07D471/04
CPC分类号： C07D471/04
摘要： A compound of formula (I), or a pharmaceutically acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p38-mediated disease, disorder, or condition, in particular the allergic and non-allergic airways diseases, more particularly obstructive or inflammatory airways diseases, preferably chronic obstructive pulmonary disease.
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