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    Cyclopentane derivatives
    2.
    发明授权
    Cyclopentane derivatives 失效
    环戊烷衍生物

    公开(公告)号：US5155112A

    公开(公告)日：1992-10-13

    申请号：US617160

    申请日：1990-11-23

    申请人： Richard Storer ,  Ian L. Paternoster ,  Alan D. Borthwick ,  Keith Biggadike

    发明人： Richard Storer ,  Ian L. Paternoster ,  Alan D. Borthwick ,  Keith Biggadike

    IPC分类号： C07D473/00

    CPC分类号： C07D473/00

    摘要： The present invention provides the compounds of formula (I) ##STR1## and salts and solvates thereof wherein R.sup.1 represents a hydrogen or fluorine atom or a hydroxy group, R.sup.2 represents a fluorine atom or a hydroxyl or C.sub.1-6 alkoxy group and B represents a purine base, and describes processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of viral infections, particularly those caused by the Herpetoviridae.

    摘要翻译： 本发明提供式（I）化合物及其盐和溶剂化物，其中R1表示氢或氟原子或羟基，R2表示氟原子或羟基或C1-6烷氧基，B表示 代表嘌呤碱，并描述其制备方法，含有它们的药物组合物及其在治疗病毒感染中的用途，特别是由疱疹病毒科引起的病毒感染。

    2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
    8.
    发明授权
    2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections 有权
    2'和3'-核苷前药用于治疗黄病毒科感染

    公开(公告)号：US07625875B2

    公开(公告)日：2009-12-01

    申请号：US11005444

    申请日：2004-12-06

    申请人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    发明人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07K9/003 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  C07H19/06 ,  C07H19/067 ,  A61K2300/00

    摘要： 2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

    摘要翻译： 描述了1'，2'，3'或4'-支链β-D或β-L核苷的2'和3'-前药，或其药学上可接受的盐和衍生物，其可用于预防和治疗黄病毒科 感染等相关条件。 这些修饰的核苷对黄病毒和瘟病毒提供了优异的结果，包括丙型肝炎病毒和通常通过RNA依赖性RNA逆转录酶复制的病毒。 提供化合物，组合物，方法和用途用于治疗包括HCV感染在内的黄病毒科感染，包括施用有效量的本发明前药或其药学上可接受的盐或衍生物。 这些药物可以任选地与另外的抗病毒剂组合或改变来施用，以预防或治疗黄病毒科感染和其他相关病症。