公开(公告)号：US06740046B2

公开(公告)日：2004-05-25

申请号：US10195956

申请日：2002-07-16

申请人： Keith N. Knapp, II ,  Alan M. Cohen

发明人： Keith N. Knapp, II ,  Alan M. Cohen

IPC分类号： A61B508

CPC分类号： A61B5/091 ,  A61B5/0809 ,  A61B5/1135 ,  A61B5/4833 ,  A61B5/486 ,  A63B23/185 ,  A63B2071/0627 ,  A63B2230/04 ,  A63B2230/30 ,  A63B2230/42 ,  G06F19/00 ,  G06F19/3481

摘要： A system for enhancing patient compliance with a predetermined breathing pattern during inspiration measurements utilizes patient feedback based on inspiration flow. The measured inspiration flow is displayed on a first display and a target inspiration flow is displayed on a second display, preferably, disposed adjacent to the first display to facilitate visual comparison. The patient is instructed to breathe in a manner that causes the measured inspiration flow display to match, or follow the target inspiration flow display.

摘要翻译： 在吸气测量期间用于增强患者对预定呼吸模式的依从性的系统利用了基于灵感流程的患者反馈。 测量的吸气流显示在第一显示器上，并且目标吸气流显示在第二显示器上，优选地与第一显示器相邻地设置，以便于视觉比较。 指示患者以使测量的吸气流显示匹配的方式呼吸，或者遵循目标吸气流显示。

公开(公告)号：US06416473B1

公开(公告)日：2002-07-09

申请号：US09592955

申请日：2000-06-13

申请人： Marcelo R. Risk ,  Alan M. Cohen ,  Daniel T. Kaplan

发明人： Marcelo R. Risk ,  Alan M. Cohen ,  Daniel T. Kaplan

IPC分类号： A61B500

CPC分类号： G06F19/321 ,  A61B5/0205 ,  A61B5/0245 ,  A61B5/0456 ,  A61B5/08 ,  A61B5/4035 ,  G06F19/00 ,  G16H15/00 ,  G16H50/50

摘要： Methods and apparatus for providing a single, accurate indicator of a patient's autonomic nervous system function are described. The indicator is a combination of results of a plurality of different autonomic nervous system tests performed on the patient and referenced to a cross-sectional population. In one embodiment, the results of the different autonomic nervous system tests are referenced to a limited age group of the cross-sectional population. A method according to the invention includes generating a mathematical expression for each of the autonomic nervous system tests as a function of physiological data of the cross-sectional population, inserting measured physiological data of the patient into the mathematical expressions to compute output values for each of the tests, and combining the output values to provide the autonomic function indicator.

摘要翻译： 描述了提供患者自主神经系统功能的单一，准确指示符的方法和装置。 该指标是对患者执行的多个不同的自主神经系统测试的结果的组合，并且以横截面总体为参考。 在一个实施例中，不同的自主神经系统测试的结果参考横截面总体的有限年龄组。 根据本发明的方法包括为每个自主神经系统测试产生数学表达式作为横截面总体的生理数据的函数，将患者的测量生理数据插入到数学表达式中，以计算每个 测试，并结合输出值提供自主功能指标。

公开(公告)号：US6161037A

公开(公告)日：2000-12-12

申请号：US426509

申请日：1999-10-26

申请人： Alan M. Cohen

发明人： Alan M. Cohen

IPC分类号： A61B5/021 ,  A61B5/0456 ,  G06F17/00 ,  A61B5/04

CPC分类号： A61B5/0456 ,  A61B5/021

摘要： Apparatus and methods for determining the precise times of occurrence of R-waves in an ECG signal of a patient. Samples of the patient's ECG signal are accumulated and an ECG window comprising a predetermined number of the samples is defined. In accordance with one embodiment of the invention, the patient's blood pressure signal is processed to detect systoles and the ECG window has a predetermined time relationship to detected systoles. In accordance with an alternative embodiment, the ECG signal is first processed to approximate the times of occurrence of R-waves and the ECG window is defined to have a predetermined time relationship to the approximated R-wave times. ECG signal samples within the ECG window are processed to determine a maximum and the time of occurrence of the maximum is stored as the time of an R-wave event.

摘要翻译： 用于确定患者的ECG信号中R波的出现精确时间的装置和方法。 累积患者ECG信号的样本，并且定义包括预定数量样本的ECG窗口。 根据本发明的一个实施例，处理患者的血压信号以检测心律，并且ECG窗口与检测到的收缩期具有预定的时间关系。 根据替代实施例，首先处理ECG信号以近似R波的出现次数，并将ECG窗口定义为与近似的R波时间具有预定的时间关系。 处理ECG窗口内的ECG信号样本以确定最大值，将最大值的发生时间存储为R波事件的时间。

公开(公告)号：US20070263563A1

公开(公告)日：2007-11-15

申请号：US11800135

申请日：2007-05-04

申请人： Andrea R. Biagioni ,  Alan M. Cohen ,  Jeffrey R. Thumm

发明人： Andrea R. Biagioni ,  Alan M. Cohen ,  Jeffrey R. Thumm

IPC分类号： H04Q7/00

CPC分类号： H04W76/40 ,  Y02D70/142 ,  Y02D70/144

摘要： A monitoring system comprises a specific remote unit or monitor and a plurality of base stations that are capable of communicating with one another. A designated one of the plurality of base stations transmits a message via a wireless medium to the specific remote unit on behalf of the plurality of base stations, and the plurality of base stations use a shared base station identifier or shared sender address for communication with the specific remote unit or monitor. In another aspect, a first designated one transmits a message during a first time period and a second designated one transmits a message during a second time period. Receiving messages from a designated one of the plurality of base stations using the shared base station identifier helps the specific remote unit or monitor to reduce its power usage.

摘要翻译： 监视系统包括特定的远程单元或监视器以及能够彼此通信的多个基站。 多个基站中的指定的一个基站代表多个基站经由无线介质将消息发送到特定远程单元，并且多个基站使用共享基站标识符或共享发送方地址来与 特定的远程单元或监视器。 在另一方面，第一指定的一个在第一时间段期间发送消息，而第二指定的一个在第二时间段期间发送消息。 使用共享基站标识符从多个基站中的指定的一个基站接收消息有助于特定的远程单元或监视器以减少其功率使用。

公开(公告)号：US06650932B1

公开(公告)日：2003-11-18

申请号：US09570683

申请日：2000-05-15

申请人： Wayne Y. Menzie ,  John Schafer ,  Keith N. Knapp, II ,  Alan M. Cohen

发明人： Wayne Y. Menzie ,  John Schafer ,  Keith N. Knapp, II ,  Alan M. Cohen

IPC分类号： A61B50205

CPC分类号： G06F19/3418 ,  A61B5/0002 ,  A61B5/024 ,  A61B5/087 ,  A61B5/7232 ,  G06F19/00 ,  G16H10/60

摘要： A medical testing system includes telemetry features whereby physiological data collected by a collection device at a medical facility is transmitted to a remote processing center for analysis by a trained analyst to provide a test result. In one embodiment, the collection device is a heart rate monitor capable of collecting data with which heart rate variability can be assessed. The heart rate monitor includes a display on which is displayed a waveform showing the breathing performance of the patient during data collection along with standards against which to compare the waveform in order to determine the extent to which the patient followed a predetermined breathing regimen during data collection. The operator of the monitor can use the performance waveform to assess how well the test was taken (i.e., how well the patient complied with the prescribed breathing regimen) and can accept or reject the physiological data accordingly. Also described is a medical testing telemetry system including two processing centers, with each collection device being capable of communicating with both processing centers. Each collection device randomly chooses one of the processing centers for analysis of the collected physiological data. The two processing centers are interconnected in order to permit physiological data and test results to be replicated and stored at both sites.

摘要翻译： 医疗测试系统包括遥测特征，其中由医疗机构处的收集装置收集的生理数据被传送到远程处理中心，以由受过训练的分析人员进行分析以提供测试结果。 在一个实施例中，收集装置是能够收集可以评估心率变异性的数据的心率监测器。 心率监测器包括一个显示器，其上显示一个波形，显示在数据采集期间患者的呼吸性能以及用于比较波形的标准，以确定患者在数据采集期间遵循预定呼吸方案的程度 。 显示器的操作者可以使用性能波形来评估测试的效果（即患者是否遵守规定的呼吸方案），并且可以相应地接受或拒绝生理数据。 还描述了包括两个处理中心的医疗测试遥测系统，每个收集装置能够与两个处理中心通信。 每个收集装置随机选择一个处理中心用于分析收集的生理数据。 两个处理中心互连，以便允许生理数据和测试结果被复制并存储在两个站点。

公开(公告)号：US6106481A

公开(公告)日：2000-08-22

申请号：US942710

申请日：1997-10-01

申请人： Alan M. Cohen

发明人： Alan M. Cohen

IPC分类号： A61B5/00 ,  A61B5/08 ,  A61B5/091 ,  A61B5/113 ,  A61N5/00

CPC分类号： A61B5/1135 ,  A61B5/091 ,  A61B5/486

摘要： A system for measuring a patient's inspiration volume and for enhancing patient compliance with a predetermined breathing pattern during inspiration volume measurements. A flexible conductive loop adapted for being wrapped around, and conforming to the patient's chest is coupled to an amplifier circuit including a signal generator and an exclusive-OR gate. The signal generator generates a square-wave signal for coupling to a first terminal of the conductive loop and the exclusive-OR gate is responsive to the applied square-wave signal and to a signal at the second terminal of the loop for measuring the delay between the signals. The output signal of the amplifier circuit is indicative of the inductance of the loop, which varies with the patient's inspiration volume. The measured inspiration volume is displayed on a first display and a target inspiration volume is displayed on a second display, preferably, disposed adjacent to the first display. The patient is instructed to breathe in a manner that causes the measured inspiration volume display to match the target inspiration volume display. In one embodiment, a measure of the patient's compliance with the predetermined breathing pattern is provided.

摘要翻译： 用于在吸气量测量期间测量患者的吸气量并用于增强患者对预定呼吸模式的依从性的系统。 适于缠绕并符合患者胸部的柔性导电环路耦合到包括信号发生器和异或门的放大器电路。 信号发生器产生一个方波信号，用于耦合到导电环路的第一端，异或门响应于所施加的方波信号和环路的第二端处的信号， 信号。 放大器电路的输出信号表示环路的电感，其随着患者的吸气量而变化。 所测量的吸气体积显示在第一显示器上，并且目标吸气体积显示在第二显示器上，优选地邻近第一显示器设置。 指示患者以使得测量的吸气量显示符合目标吸气体积显示的方式呼吸。 在一个实施例中，提供了对患者符合预定呼吸模式的量度。

公开(公告)号：US07522574B2

公开(公告)日：2009-04-21

申请号：US11800135

申请日：2007-05-04

申请人： Andrea R. Biagioni ,  Alan M. Cohen ,  Jeffrey R. Thumm

发明人： Andrea R. Biagioni ,  Alan M. Cohen ,  Jeffrey R. Thumm

IPC分类号： H04Q7/00

CPC分类号： H04W76/40 ,  Y02D70/142 ,  Y02D70/144

摘要： A monitoring system comprises a specific remote unit or monitor and a plurality of base stations that are capable of communicating with one another. A designated one of the plurality of base stations transmits a message via a wireless medium to the specific remote unit on behalf of the plurality of base stations, and the plurality of base stations use a shared base station identifier or shared sender address for communication with the specific remote unit or monitor. In another aspect, a first designated one transmits a message during a first time period and a second designated one transmits a message during a second time period. Receiving messages from a designated one of the plurality of base stations using the shared base station identifier helps the specific remote unit or monitor to reduce its power usage.

摘要翻译： 监视系统包括特定的远程单元或监视器以及能够彼此通信的多个基站。 多个基站中的指定的一个基站代表多个基站经由无线介质将消息发送到特定远程单元，并且多个基站使用共享基站标识符或共享发送方地址来与 特定的远程单元或监视器。 在另一方面，第一指定的一个在第一时间段期间发送消息，而第二指定的一个在第二时间段期间发送消息。 使用共享基站标识符从多个基站中的指定的一个基站接收消息有助于特定的远程单元或监视器以减少其功率使用。

公开(公告)号：US06436053B1

公开(公告)日：2002-08-20

申请号：US09507770

申请日：2000-02-18

申请人： Keith N. Knapp, II ,  Alan M. Cohen

发明人： Keith N. Knapp, II ,  Alan M. Cohen

IPC分类号： A61B508

CPC分类号： A61B5/091 ,  A61B5/0809 ,  A61B5/1135 ,  A61B5/4833 ,  A61B5/486 ,  A63B23/185 ,  A63B2071/0627 ,  A63B2230/04 ,  A63B2230/30 ,  A63B2230/42 ,  G06F19/00 ,  G06F19/3481

摘要： A system for enhancing patient compliance with a predetermined breathing pattern during inspiration measurements utilizes patient feedback based on inspiration flow. The measured inspiration flow is displayed on a first display and a target inspiration flow is display on a second display, preferably, disposed adjacent to the first display to facilitate visual comparison. The patient is instructed to breathe in manner that causes the measured inspiration flow display to match, or flow the target inspiration flow display.

摘要翻译： 在吸气测量期间用于增强患者对预定呼吸模式的依从性的系统利用了基于灵感流程的患者反馈。 所测量的吸气流显示在第一显示器上，并且目标吸气流量显示在第二显示器上，优选地邻近第一显示器设置，以便于视觉比较。 指示患者以使测量的吸气流量显示匹配的方式呼吸，或者流动目标吸气流量显示。

公开(公告)号：US5984954A

公开(公告)日：1999-11-16

申请号：US940396

申请日：1997-10-01

申请人： Alan M. Cohen

发明人： Alan M. Cohen

IPC分类号： A61B5/021 ,  A61B5/0456 ,  G06F17/00

CPC分类号： A61B5/0456 ,  A61B5/021

摘要： Apparatus and methods for determining the precise times of occurrence of R-waves in an ECG signal of a patient. Samples of the patient's ECG signal are accumulated and an ECG window comprising a predetermined number of the samples is defined. In accordance with one embodiment of the invention, the patient's blood pressure signal is processed to detect systoles and the ECG window has a predetermined time relationship to detected systoles. In accordance with an alternative embodiment, the ECG signal is first processed to approximate the times of occurrence of R-waves and the ECG window is defined to have a predetermined time relationship to the approximated R-wave times. ECG signal samples within the ECG window are processed to determine a maximum and the time of occurrence of the maximum is stored as the time of an R-wave event.