公开(公告)号：US20100130608A1

公开(公告)日：2010-05-27

申请号：US12572263

申请日：2009-10-01

申请人： Alan Stuart RYAN ,  Edward B. Nelson ,  Jung Lee ,  Krishna Raman

发明人： Alan Stuart RYAN ,  Edward B. Nelson ,  Jung Lee ,  Krishna Raman

IPC分类号： A61K31/22 ,  A61K31/202 ,  A61P3/00

CPC分类号： A61K31/232 ,  A61K31/20 ,  A61K31/201 ,  A61K2300/00

摘要： The present invention is directed to methods of reducing plasma triglyceride level in subjects by administering docosahexaenoic acid (DHA). The method can comprise administering daily to the subject a dosage form comprising docosahexaenoic acid ester substantially free of eicosapentaenoic acid (EPA), wherein the DHA is derived from an algal source. In some embodiments, the method comprises administering daily to the subject a dosage form comprising DHA ester substantially free of EPA, wherein the DHA ester is about 60% to about 99.5% (w/w) of the total fatty acid content of the dosage form. In some embodiments, the method comprises administering daily to the subject a dosage form comprising about 200 mg to about 4 g of DHA ester substantially free of EPA. In some embodiments, the foregoing methods also result in a lowering of the amount of total cholesterol in the subject.

摘要翻译： 本发明涉及通过施用二十二碳六烯酸（DHA）来减少受试者血浆甘油三酯水平的方法。 该方法可以包括向受试者施用基本上不含二十碳五烯酸（EPA）的二十二碳六烯酸酯的剂型，其中DHA来源于藻源。 在一些实施方案中，该方法包括向受试者施用包含基本上不含EPA的DHA酯的剂型，其中DHA酯为剂型总脂肪酸含量的约60％至约99.5％（w / w） 。 在一些实施方案中，该方法包括向受试者施用包含约200mg至约4g基本上不含EPA的DHA酯的剂型。 在一些实施方案中，前述方法还导致受试者中总胆固醇的量的降低。