公开(公告)号：US09506063B2

公开(公告)日：2016-11-29

申请号：US13752568

申请日：2013-01-29

申请人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

发明人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

IPC分类号： C12N15/113

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/31

摘要： The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections.

摘要翻译： 本发明提供了siRNA组合物，其（1）干扰人乳头状瘤病毒（HPV），单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）在粘膜组织如生殖器官组织中的病毒复制，和（2）治疗真菌感染 。 组合物包括靶向HPV的siRNA分子，与治疗和预防生殖器疱疹（HSV）和HIV的树突状细胞复合。 组合物还包括靶向HPV的siRNA分子，与治疗和预防真菌感染的组氨酸 - 赖氨酸（HK）聚合物复合。 siRNA和树枝状大分子的组合制剂提供了对HPV，HSV和HIV感染的治疗。 siRNA和HK聚合物的组合制剂提供对HPV和真菌感染的治疗。

公开(公告)号：US20130345284A1

公开(公告)日：2013-12-26

申请号：US13752568

申请日：2013-01-29

申请人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

发明人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

IPC分类号： C12N15/113

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/31

摘要： The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections.

摘要翻译： 本发明提供了siRNA组合物，其（1）干扰人乳头状瘤病毒（HPV），单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）在粘膜组织如生殖器官组织中的病毒复制，和（2）治疗真菌感染 。 组合物包括靶向HPV的siRNA分子，与治疗和预防生殖器疱疹（HSV）和HIV的树突状细胞复合。 组合物还包括靶向HPV的siRNA分子，与治疗和预防真菌感染的组氨酸 - 赖氨酸（HK）聚合物复合。 siRNA和树枝状大分子的组合制剂提供了对HPV，HSV和HIV感染的治疗。 siRNA和HK聚合物的组合制剂提供对HPV和真菌感染的治疗。

公开(公告)号：US4253003A

公开(公告)日：1981-02-24

申请号：US911123

申请日：1978-05-31

申请人： David M. Evans ,  Edward J. Rogers

发明人： David M. Evans ,  Edward J. Rogers

IPC分类号： H01H3/30 ,  H01H3/32

CPC分类号： H01H3/3031

摘要： Disclosed is an improved high voltage switch operating mechanism which utilizes energy stored in a spiral spring to drive high voltage switches from either the open to the closed position or the closed to the open position. A spiral spring interconnects a rotatably mounted drive lever, which can be rotated to charge the sprial spring, and an output lever, which drives the switch either open or closed when the switch operating mechanism is tripped. A gearbox assembly reduces the torque required to charge the spiral spring when supplied either manually with a crank or electrically through a motor. The output lever is held in the switch-closed or the switch-opened position by improved first or second output lever latch assemblies, respectively, while the drive lever is rotated to charge the spring. Once the spiral spring is charged, first and second main latches engage the drive lever holding it in a spring charged position. The switch operating mechanism is tripped by releasing first or second output lever latch assemblies, which can be released manually by a single trip handle or by solenoids connected to control circuitry. When tripped, the spiral spring reacts against the output lever to either open or close the switch depending on the position of the switch at the initiation of the operation. After a switching operation is completed, the spring can be recharged for the next operation. Manual and electrical trip interlock assemblies are provided to prevent the switch operating mechanism from being tripped either manually or electrically while the spiral spring is being recharged either manually or electrically.

摘要翻译： 公开了一种改进的高压开关操作机构，其利用存储在螺旋弹簧中的能量来驱动高压开关从打开位置到闭合位置或闭合位置到打开位置。 螺旋弹簧互连可旋转地安装的驱动杆，其可旋转以对弹簧弹簧充电;以及输出杆，其在开关操作机构跳闸时驱动开关打开或关闭。 齿轮箱组件减少了当用曲柄手动地或通过电动机供电时为螺旋弹簧充电所需的扭矩。 输出杆通过改进的第一或第二输出杆闩锁组件分别保持在开关闭合或开关打开位置，同时驱动杆旋转以对弹簧充电。 一旦螺旋弹簧被充电，第一和第二主闩锁接合驱动杆，该驱动杆将其保持在弹簧充电位置。 开关操作机构通过释放第一或第二输出杆闩锁组件来跳闸，该闩锁组件可以由单个跳闸手柄或连接到控制电路的螺线管手动释放。 当跳闸时，螺旋弹簧响应于输出杆，以根据开关在操作开始时的位置来打开或关闭开关。 切换操作完成后，可以对弹簧进行充电以进行下一个操作。 提供手动和电动跳闸互锁组件，以防止开关操作机构手动或电动跳闸，同时螺旋弹簧手动或电动充电。

公开(公告)号：US4107487A

公开(公告)日：1978-08-15

申请号：US775905

申请日：1977-03-09

申请人： David M. Evans

发明人： David M. Evans

IPC分类号： H01H3/46 ,  H01H33/44

CPC分类号： H01H3/46 ,  Y10T74/20594

摘要： Disclosed is a switch suitable for use in power systems. The switch is of the vertical break type, having two stationary support insulators and one reciprocatory, insulative push rod, wherein movement of a switch blade takes place in a plane which also includes the insulators and the push rod. The two insulators are mounted on a base, one insulator supporting a switch blade hinge assembly, and the other insulator supporting a contact assembly for the switch blade. A novel linkage mounted to the hinge assembly connects the blade to the push rod and permits at least 90.degree. of movement of the blade without adversely affecting dielectric clearances between the push rod and the insulators. The insulators remain stationary when the switch operates, only the push rod and the novel linkage moving to provide motive force to the blade. The push rod may be reciprocated by interconnection to a rotatable shaft via a lever. The shaft may be connected to an operating pipe reciprocated by a remote operator to rotation therewith. After the switch is open, the novel linkage permits the push rod and the lever to form an over-center toggle which, together with the more than 90.degree. opening of the blade, prevents the blade from inadvertently moving toward engagement with the stationary contact as a result of external forces such as wind, etc. The switch and the linkage are usable in single pole and polyphase switches in a variety of configurations.

摘要翻译： 公开了一种适用于电力系统的开关。 该开关具有垂直断开型，具有两个固定支撑绝缘体和一个往复绝缘推杆，其中开关叶片的运动发生在还包括绝缘体和推杆的平面中。 两个绝缘体安装在基座上，一个绝缘体支撑开关叶片铰链组件，另一个绝缘体支撑开关叶片的接触组件。 安装到铰链组件的新型连杆将叶片连接到推杆，并且允许叶片的至少90°的运动，而不会不利地影响推杆和绝缘体之间的介电间隙。 当开关操作时，绝缘体保持静止，只有推杆和新型联动装置移动以向叶片提供动力。 推杆可以通过杠杆通过互连到可旋转轴而往复运动。 轴可以连接到由远程操作者往复运动的操作管以与其一起旋转。 在开关打开之后，新的联动装置允许推杆和杠杆形成一个超中心的肘节，其与刀片的大于90°的开口一起防止了刀片不经意地移动以与固定触点接合作为 外部力（如风等）的结果。开关和联动装置可用于各种结构的单极和多相开关。

公开(公告)号：US5251245A

公开(公告)日：1993-10-05

申请号：US943954

申请日：1992-09-11

申请人： David M. Evans ,  Ricky L. Tucker ,  John O. Izzo

发明人： David M. Evans ,  Ricky L. Tucker ,  John O. Izzo

IPC分类号： F16J13/20 ,  F22B1/16 ,  F22B37/22 ,  G21C17/003 ,  G21D1/00 ,  G21F3/00 ,  G21F7/005 ,  G21C11/02

CPC分类号： F22B37/221 ,  G21F7/005

摘要： A shielded access door for a nuclear steam generator manway port having a beam of radiation streaming therethrough, the port being surrounded by a manway flange. The door comprises a bracket adapted to be removably connected to the flange. A plurality of swing arms have the first end portion thereof pivotally connected to the bracket. A first shield member is connected to the second end portions of the arms and is disposed parallel and adjacent to the port for shielding against the beam of radiation. The first shield member and the port define a gap therebetween for allowing access to the steam generator interiorly of the port while simultaneously shielding against the beam of radiation. The first shield member has a ventilation hole therethrough in communication with the port for ventilating the port, so that air-borne radioactive particles present interiorly of the steam generator are exhausted from the steam generator. A second shield member, which is attached to the first shield member, is coaxially aligned with the hole of the first shield member and is spaced-apart from the first shield member for preventing the beam of radiation from exiting through the ventilation hole. The second shield member is capable of being interposed between the beam of radiation and the hole for shielding the hole against the beam of radiation. Moreover, the first shield member is formed of light weight connectable segments to facilitate lifting and positioning of the door at the manway port.

摘要翻译： 一种用于核蒸汽发生器操纵口的屏蔽通道门，其具有从其中流过的辐射束，该端口被一个人造路面凸缘包围。 门包括适于可拆卸地连接到凸缘的支架。 多个摆臂的第一端部枢转地连接到支架。 第一屏蔽构件连接到臂的第二端部并且平行并且邻近端口设置以防止辐射束。 第一屏蔽构件和端口在其间限定了间隙，以允许在端口内部进入蒸汽发生器同时屏蔽辐射束。 第一屏蔽构件具有与端口连通的通气孔，用于使端口通风，使得存在于蒸汽发生器内部的空气传播的放射性颗粒从蒸汽发生器排出。 附接到第一屏蔽构件的第二屏蔽构件与第一屏蔽构件的孔同轴地对准，并且与第一屏蔽构件间隔开，以防止辐射束从通风孔排出。 第二屏蔽构件能够插入在辐射束和孔之间，用于遮蔽孔抵抗辐射束。 此外，第一屏蔽构件由重量轻的连接段形成，以便于门在出口口处的提升和定位。

公开(公告)号：US5142859A

公开(公告)日：1992-09-01

申请号：US658830

申请日：1991-02-22

申请人： Boris Glezer ,  David M. Evans

发明人： Boris Glezer ,  David M. Evans

IPC分类号： F01D5/08 ,  F02C7/18 ,  F02C7/28

CPC分类号： F02C7/28 ,  F01D5/082 ,  F02C7/18

摘要： Cooling air delivery systems for gas turbine engines are used to increase component life and increase power and efficiencies. The present system increases the component life and increases efficiencies by better utilizing the cooling air bled from the compressor section of the gas turbine engine. For example, a first flow of cooling air is directed to the nozzle and shroud assembly and another portion of the first flow is exited from the nozzle plenum into an annular reservoir to improve cooling of a rotor assembly and to at least reduce ingestion of hot power gases into the internal portion of the engine. The system further includes a second flow of cooling air which is directed through internal passages of the engine and into the annular reservoir and is used to cool the rotor assembly and to at least reduce ingestion of hot power gases into the internal portion of the gas turbine engine. To insure that the least amount of hot power gas is ingested into the internal portion of the engine is minimized a radial blade flange arrangement and a radial shroud flange arrangement axially overlap each other in a preestablished radially spaced proximity forming a buffering zone therebetween into which the mixed cooling air in the annular reservoir is directed. Thus, increasing component life and increasing power and efficiencies of the engine.

摘要翻译： 用于燃气涡轮发动机的冷却空气输送系统用于增加部件寿命并提高功率和效率。 本系统通过更好地利用从燃气涡轮发动机的压缩机部分排出的冷却空气来增加部件寿命并提高效率。 例如，冷却空气的第一流动被引导到喷嘴和护罩组件，并且第一流的另一部分从喷嘴压力室排出到环形容器中，以改善转子组件的冷却并且至少减少摄取热功率 气体进入发动机的内部。 该系统还包括冷却空气的第二流动，其被引导通过发动机的内部通道并进入环形容器，并用于冷却转子组件，并且至少减少热能气体进入燃气轮机的内部部分 发动机。 为了确保将最少量的热功率气体吸入发动机的内部部分的最小化使径向叶片凸缘布置和径向护罩法兰布置在预先成形的径向间隔开的邻近处轴向重叠，形成其间的缓冲区， 指向环形储存器中的混合冷却空气。 因此，增加发动机的部件寿命和提高功率和效率。

公开(公告)号：US4375703A

公开(公告)日：1983-03-08

申请号：US253513

申请日：1981-04-15

申请人： David M. Evans ,  Barry O. Weightman

发明人： David M. Evans ,  Barry O. Weightman

IPC分类号： A61F2/30 ,  A61F2/42 ,  A61F1/04 ,  A61F5/04

CPC分类号： A61F2/4241 ,  A61F2002/30626 ,  A61F2002/3063 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/4251

摘要： Endoprosthetic metacarpal phalangeal joint devices are well known in various forms including unitary flexible structures for connection between the bones, and others with separate phalangeal and metacarpal components for respective bone connection and inter-engagement or connection for mutual articulation in a hinge action. All such devices are applied individually to respective joints and can tend to fail due to conditions leading to ulnar drift. It is now proposed that this tendency be obviated by mechanically interconnecting a plurality of devices of the latter form in the hand, suitably by use of a common hinge pin. The pin preferably has slight longitudinal curvature to pass through the natural joint centers. The phalangeal components preferably each have a socket for bone connection and a stem for axle connection, the stem being slidably and rotatably received in the socket to accomodate torsional loading.

摘要翻译： PCT No.PCT / GB80 / 00127 Sec。 371日期：1981年4月15日 102（e）日期1981年4月15日PCT提交1980年8月12日PCT公布。 No.W081 / 00511 PCT出版物 日前，1981年3月5日。假体掌骨指骨关节装置以各种形式是众所周知的，包括用于骨骼之间连接的单一柔性结构，以及用于相应骨连接和相互接合或相互连接的相互接合或连接的单独的指骨和掌骨部件 铰链动作。 所有这些装置分别应用于各个关节，并且由于导致尺骨漂移的条件而可能会失败。 现在提出，通过适当地通过使用公共铰链销将手中的后一种形式的多个装置机械地互连来消除这种趋势。 销优选具有轻微的纵向曲率以穿过天然接合中心。 指骨部件优选地各自具有用于骨连接的插座和用于轴连接的杆，所述杆可滑动地且可旋转地容纳在插座中以适应扭转载荷。

公开(公告)号：US4123639A

公开(公告)日：1978-10-31

申请号：US837243

申请日：1977-09-27

申请人： David M. Evans

发明人： David M. Evans

IPC分类号： H01H31/02 ,  H01H1/42

CPC分类号： H01H31/023

摘要： An improved support assembly for a circuit-interrupting device is disclosed. The device is of a type having first and second end fittings which define a major axis and which are selectively engageable and disengageable from matching first and second mountings spaced apart in the assembly in insulated relation. The device can be manipulated by a hookstick selectively attachable to the first end fitting and held by a human operator, and so manipulated as to selectively engage and disengage the end fittings and their respective mountings and to open and close the device. The second mounting has a noncircular pin which can be slideably received in a slot in the second end fitting only when the second end fitting and the device are in one particular orientation. The slot contains an enlargement which permits the second end fitting to rotate in the second mounting once the pin enters the enlargement. When the pin is in the enlargement, the device is freely rotatable to both the closed position and the opened position. A cradle, provided on the second mounting for supporting the device, is utilized at two times. First, the cradle supports the device when the second end fitting is being engaged with the second mounting. It performs such support function to automatically place the second end fitting in the one orientation in which it may slideably engage the end fitting. Second, the cradle arrests rotation of, and supports, the device following an opening operation during which the first end fitting is disengaged from the first mounting. Such arresting and support function also automatically aligns the pin in the slot so that the device may be removed from the second mounting.

摘要翻译： 公开了一种用于电路中断装置的改进的支撑组件。 该装置是具有第一和第二端部配件的类型，其具有限定长轴线的第一和第二端部配件，其可选择性地与绝缘关系中的组件中间隔开的匹配第一和第二安装件接合并脱离。 该装置可以由可选择性地附接到第一端配件并由人操作者保持的钩杆来操纵，并且被操纵以便选择性地接合和分离端部配件及其相应的安装件并且打开​​和关闭该装置。 第二安装件具有非圆形销，只有当第二端配件和装置处于一个特定方向时，该销可以可滑动地容纳在第二端配件的槽中。 一旦插脚进入放大状态，插槽就会有一个放大图，允许第二端配件在第二个安装中旋转。 当销处于放大状态时，该装置可自由旋转至关闭位置和打开位置。 设置在用于支撑装置的第二安装件上的托架被两次使用。 首先，当第二端配件与第二安装件接合时，支架支撑设备。 它执行这种支撑功能，以自动将第二端配件放置在可滑动地接合端部配件的一个方向上。 其次，在第一端配件与第一安装件脱离接合的打开操作之后，托架阻止设备的旋转并支撑该设备。 这种止动和支撑功能还可自动地将销钉对准插槽，使得装置可以从第二安装件移除。

公开(公告)号：US07335677B2

公开(公告)日：2008-02-26

申请号：US10491794

申请日：2002-10-23

申请人： David M. Evans ,  Doreen M. Ashworth

发明人： David M. Evans ,  Doreen M. Ashworth

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/4025

CPC分类号： C07D207/335 ,  C07D207/10 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/62 ,  C07D213/38 ,  C07D213/74 ,  C07D213/82 ,  C07D215/12 ,  C07D251/50 ,  C07D251/52 ,  C07D277/04 ,  C07D295/185 ,  C07D307/06 ,  C07D307/81 ,  C07D317/66 ,  C07D333/20 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

摘要： Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R1 is H or CN, X1 is O, S, CH2, CHF, CF2, CH(CH3), C(CH3)2 or CH(CN), and b is 1 or 2. G1 is H or a group according to the formula —CH2—X2—(CH2)a-G3 and G2 is H or a group according to the formula —CH2—(CH29a-G3, provided that one of G1 and G2 is H and the other is not H. X2 is O, S, or CH2, and a is 0, 1 or 2, provided that when a is 1 then X2 is CH2. G3 is a group according to one of general formulae 2-4, where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance

摘要翻译： 一种或多种后脯氨酸切割蛋白酶的抑制剂的新型化合物，例如 二肽基肽酶IV，根据通式（1）。 R 1是H或CN，X 1是O，S，CH 2，CHF，CF 2， CH（CH 3）3，C（CH 3）2或CH（CN），b为1或2.G < 1是H或根据式-CH 2的基团-X 2 - （CH 2）2 G 2和H 2是H或根据式-CH 2 - （CH 2）2的基团， 只要G 1和G 2中的一个是H，且< 另一个不是H.X 2是O，S或CH 2，并且a是0,1或2，条件是当a是1时，X _{2 是CH 2，G 3是根据通式2-4之一的基团，其中变量具有在说明书中给出的含义。 化合物可用于治疗2型糖尿病和糖耐量异常}

公开(公告)号：USD278099S

公开(公告)日：1985-03-26

申请号：US352192

申请日：1982-02-25

申请人： David M. Evans

设计人： David M. Evans