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公开(公告)号:US20080108789A1
公开(公告)日:2008-05-08
申请号:US11982657
申请日:2007-11-02
申请人: Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Joanne Kehlbeck Martin , Neal Zondlo
发明人: Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Joanne Kehlbeck Martin , Neal Zondlo
CPC分类号: C40B40/02 , C07K14/00 , C07K14/465 , C07K2319/00 , C12N15/1037 , C12N15/62
摘要: The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.
摘要翻译: 本发明提供蛋白质支架,例如禽胰腺多肽,当多肽处于三级形式时,可通过取代暴露于多肽的α螺旋结构域上的两个或更多个氨基酸残基来修饰。