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公开(公告)号:US20080108789A1
公开(公告)日:2008-05-08
申请号:US11982657
申请日:2007-11-02
申请人: Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Joanne Kehlbeck Martin , Neal Zondlo
发明人: Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Joanne Kehlbeck Martin , Neal Zondlo
CPC分类号: C40B40/02 , C07K14/00 , C07K14/465 , C07K2319/00 , C12N15/1037 , C12N15/62
摘要: The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.
摘要翻译: 本发明提供蛋白质支架,例如禽胰腺多肽,当多肽处于三级形式时,可通过取代暴露于多肽的α螺旋结构域上的两个或更多个氨基酸残基来修饰。
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公开(公告)号:US20050287542A1
公开(公告)日:2005-12-29
申请号:US10982727
申请日:2004-11-04
申请人: Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Tanya Schneider , Heather Volkman
发明人: Alanna Shrader , Jason Chin , Reena Zutshi , Stacey Rutledge , Tanya Schneider , Heather Volkman
IPC分类号: A61K38/00 , A61K38/28 , C07H21/04 , C07K14/465 , C07K14/575 , C12N5/06 , C12Q1/68
CPC分类号: C07K14/465 , A61K38/00 , C07K14/00 , C07K2319/00 , C12N15/1037 , C12N15/62 , C40B40/02
摘要: The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.
摘要翻译: 本发明提供蛋白质支架,例如禽胰腺多肽,当多肽处于三级形式时,可通过取代暴露于多肽的α螺旋结构域上的两个或更多个氨基酸残基来修饰。
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公开(公告)号:US20050277592A1
公开(公告)日:2005-12-15
申请号:US11111218
申请日:2005-04-21
申请人: Alanna Shrader , Scott Hart , Joshua Kritzer , Olen Stephens
发明人: Alanna Shrader , Scott Hart , Joshua Kritzer , Olen Stephens
IPC分类号: A61K38/00 , A61K38/16 , C07C237/22 , C07K14/005
CPC分类号: C07C237/24 , A61K38/00 , C07C237/22 , C07C2601/14
摘要: β-peptide regions of polypeptides can serve as structural mimics of α-helices in wild type proteins. Because α-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical β-peptide region can be used to disrupt this type of protein-protein binding. As a result, polypeptides that contain a helical β-peptide region can be used to treat conditions involving this type of protein-protein binding, such as viral infections and cell proliferation.
摘要翻译: 多肽的β-肽区域可以作为野生型蛋白质中α-螺旋的结构模拟物。 因为一种蛋白质的α-螺旋通常与生物学途径中的靶蛋白结合,所以含有螺旋β-肽区域的多肽可用于破坏这种类型的蛋白质 - 蛋白质结合。 因此,含有螺旋β-肽区域的多肽可用于治疗涉及这种类型的蛋白质 - 蛋白质结合的病症,例如病毒感染和细胞增殖。
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