公开(公告)号：US20100267166A1

公开(公告)日：2010-10-21

申请号：US12823961

申请日：2010-06-25

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/558 ,  G01N30/96

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

公开(公告)号：US08268636B2

公开(公告)日：2012-09-18

申请号：US12823961

申请日：2010-06-25

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

公开(公告)号：US08211711B2

公开(公告)日：2012-07-03

申请号：US12823949

申请日：2010-06-25

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

摘要翻译： 本发明包括用于检测沉积在装置的第一部分上的液体样品中的分析物的装置，用于输送到与第一部分流体接触的装置的第二部分。 在具体实施方案中，该装置包含标记的缀合物，其包含与分析物的第一表位反应的结合成员和包含金胶体的标签，其优选具有50nm至100nm的平均粒度。 在另外的实施方案中，该装置包含包含聚合的链霉亲和素的捕获组分。 诊断装置在制备妊娠试剂盒中特别有用。

公开(公告)号：US07776618B2

公开(公告)日：2010-08-17

申请号：US11681061

申请日：2007-03-01

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/543

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

摘要翻译： 本发明包括用于检测沉积在装置的第一部分上的液体样品中的分析物的装置，用于输送到与第一部分流体接触的装置的第二部分。 在具体实施方案中，该装置包含标记的缀合物，其包含与分析物的第一表位反应的结合成员和包含金胶体的标签，其优选具有50nm至100nm的平均粒度。 在另外的实施方案中，该装置包含包含聚合的链霉亲和素的捕获组分。 诊断装置在制备妊娠试剂盒中特别有用。

公开(公告)号：US20080213920A1

公开(公告)日：2008-09-04

申请号：US11681061

申请日：2007-03-01

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/536

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

摘要翻译： 本发明包括用于检测沉积在装置的第一部分上的液体样品中的分析物的装置，用于输送到与第一部分流体接触的装置的第二部分。 在具体实施方案中，该装置包含标记的缀合物，其包含与分析物的第一表位反应的结合成员和包含金胶体的标签，其优选具有50nm至100nm的平均粒度。 在另外的实施方案中，该装置包含包含聚合的链霉亲和素的捕获组分。 诊断装置在制备妊娠试剂盒中特别有用。

公开(公告)号：US20100261293A1

公开(公告)日：2010-10-14

申请号：US12823949

申请日：2010-06-25

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/543 ,  G01N31/22

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

摘要翻译： 本发明包括用于检测沉积在装置的第一部分上的液体样品中的分析物的装置，用于输送到与第一部分流体接触的装置的第二部分。 在具体实施方案中，该装置包含标记的缀合物，其包含与分析物的第一表位反应的结合成员和包含金胶体的标签，其优选具有50nm至100nm的平均粒度。 在另外的实施方案中，该装置包含包含聚合的链霉亲和素的捕获组分。 诊断装置在制备妊娠试剂盒中特别有用。

公开(公告)号：US09939385B2

公开(公告)日：2018-04-10

申请号：US13229156

申请日：2011-09-09

申请人： Albert Nazareth ,  Andy Sturman ,  Benedict Zin ,  Yea-Shun Cheng ,  Henry Bell ,  Shang Li

发明人： Albert Nazareth ,  Andy Sturman ,  Benedict Zin ,  Yea-Shun Cheng ,  Henry Bell ,  Shang Li

IPC分类号： G01N21/84

CPC分类号： G01N21/8483

摘要： Systems, methods, and test kits for monitoring and detecting variation in an analyte level in a fluid sample from an individual variation using a uniquely determined analyte threshold value. In one implementation, luteinizing hormone is the monitored analyte and is compared with the determined threshold value to predict the onset of ovulation for the individual.

公开(公告)号：US07045342B2

公开(公告)日：2006-05-16

申请号：US10794516

申请日：2004-03-05

申请人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

发明人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

IPC分类号： C12M3/00

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

摘要： The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Disposed within the cell is a sample absorbent, a novel biphasic substrate and a reservoir, together capable of transporting an aqueous solution within the casing along a flow path extending from the sample inlet through the test volume and into the reservoir volume. The invention further comprises a method for detecting the presence of an analyte in a liquid sample using the device and a biphasic chromatographic material for carrying out the method.

公开(公告)号：US06767714B2

公开(公告)日：2004-07-27

申请号：US09951007

申请日：2001-09-12

申请人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

发明人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

IPC分类号： G01N33543

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

摘要： The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Disposed within the cell is a sample absorbent, a novel biphasic substrate and a reservoir, together capable of transporting an aqueous solution within the casing along a flow path extending from the sample inlet through the test volume and into the reservoir volume. The invention further comprises a method for detecting the presence of an analyte in a liquid sample using the device and a biphasic chromatographic material for carrying out the method.

公开(公告)号：US06319676B1

公开(公告)日：2001-11-20

申请号：US08432894

申请日：1995-05-02

申请人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

发明人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

IPC分类号： G01N33558

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

摘要： The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Disposed within the cell is a sample absorbent, a novel biphasic substrate and a reservoir, together capable of transporting an aqueous solution within the casing along a flow path extending from the sample inlet through the test volume and into the reservoir volume. The invention further comprises a method for detecting the presence of an analyte in a liquid sample using the device and a biphasic chromatographic material for carrying out the method.

摘要翻译： 本发明提供了用于检测液体样品中分析物的存在的改进的测试池。 该装置具有限定液体样品入口，储存器容积，测试体积和在测试体积处通过壳体的窗口的细长壳体。 在细胞内设置的是样品吸收剂，新颖的双相基底和储存器，它们一起能够沿着从样品入口延伸穿过测试体积并进入储存容积的流动路径输送壳体内的水溶液。 本发明还包括使用该装置和用于执行该方法的双相色谱材料来检测液体样品中分析物的存在的方法。