公开(公告)号：US08268636B2

公开(公告)日：2012-09-18

申请号：US12823961

申请日：2010-06-25

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

公开(公告)号：US20120083044A1

公开(公告)日：2012-04-05

申请号：US12967971

申请日：2010-12-14

申请人： Andy Sturman ,  Benedict Zin ,  Albert Nazareth ,  Henry Bell

发明人： Andy Sturman ,  Benedict Zin ,  Albert Nazareth ,  Henry Bell

IPC分类号： G01N21/75

CPC分类号： G01N33/48792 ,  G01N21/17 ,  G01N21/8483 ,  G01N33/48785 ,  G01N33/493 ,  G01N33/62 ,  G01N33/689 ,  G01N33/76 ,  G01N2201/062 ,  G01N2201/12 ,  G01N2333/59

摘要： An improved electronic diagnostic device for detecting the presence of an analyte in a fluid sample comprises a casing having a display, a test strip mounted in the casing, a processor mounted in the casing, and a first sensor mounted in the casing and operatively coupled to the processor. The processor is configured to receive a signal from the first sensor when the device is exposed to ambient light thereby causing the device to become activated. The device includes a light shield that exerts pressure across a width of the test strip to prevent fluid channeling along the length of the test strip. The processor is configured to present an early positive test result reading when a measured value exceeds a predetermined early reading threshold value at any time after a predetermined early testing time period.

摘要翻译： 用于检测流体样品中分析物的存在的改进的电子诊断装置包括具有显示器的壳体，安装在壳体中的测试条，安装在壳体中的处理器，以及安装在壳体中并可操作地耦合到 处理器。 该处理器被配置为当该设备暴露于环境光从而导致该设备被激活时从第一传感器接收信号。 该装置包括遮光板，其在测试条的宽度上施加压力，以防止沿着测试条的长度的流体通道。 处理器被配置为当在预定的早期测试时间段之后的任何时间测量值超过预定的早期读取阈值时呈现早期的正测试结果读数。

公开(公告)号：US08828329B2

公开(公告)日：2014-09-09

申请号：US12967971

申请日：2010-12-14

申请人： Andy Sturman ,  Benedict Zin ,  Albert Nazareth ,  Henry Bell

发明人： Andy Sturman ,  Benedict Zin ,  Albert Nazareth ,  Henry Bell

IPC分类号： G01N21/75 ,  G01N21/84

CPC分类号： G01N33/48792 ,  G01N21/17 ,  G01N21/8483 ,  G01N33/48785 ,  G01N33/493 ,  G01N33/62 ,  G01N33/689 ,  G01N33/76 ,  G01N2201/062 ,  G01N2201/12 ,  G01N2333/59

摘要： An improved electronic diagnostic device for detecting the presence of an analyte in a fluid sample comprises a casing having a display, a test strip mounted in the casing, a processor mounted in the casing, and a first sensor mounted in the casing and operatively coupled to the processor. The processor is configured to receive a signal from the first sensor when the device is exposed to ambient light thereby causing the device to become activated. The device includes a light shield that exerts pressure across a width of the test strip to prevent fluid channeling along the length of the test strip. The processor is configured to present an early positive test result reading when a measured value exceeds a predetermined early reading threshold value at any time after a predetermined early testing time period.

摘要翻译： 用于检测流体样品中分析物的存在的改进的电子诊断装置包括具有显示器的壳体，安装在壳体中的测试条，安装在壳体中的处理器，以及安装在壳体中并可操作地耦合到 处理器。 该处理器被配置为当该设备暴露于环境光从而导致该设备被激活时从第一传感器接收信号。 该装置包括遮光板，其在测试条的宽度上施加压力，以防止沿着测试条的长度的流体通道。 处理器被配置为当在预定的早期测试时间段之后的任何时间测量值超过预定的早期读取阈值时呈现早期的正测试结果读数。

公开(公告)号：US20100267166A1

公开(公告)日：2010-10-21

申请号：US12823961

申请日：2010-06-25

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/558 ,  G01N30/96

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

公开(公告)号：US20100261293A1

公开(公告)日：2010-10-14

申请号：US12823949

申请日：2010-06-25

申请人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

发明人： Albert Nazareth ,  Timothy Snowden ,  Yea-shun Cheng

IPC分类号： G01N33/543 ,  G01N31/22

CPC分类号： G01N33/558 ,  G01N2333/59 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.

摘要翻译： 本发明包括用于检测沉积在装置的第一部分上的液体样品中的分析物的装置，用于输送到与第一部分流体接触的装置的第二部分。 在具体实施方案中，该装置包含标记的缀合物，其包含与分析物的第一表位反应的结合成员和包含金胶体的标签，其优选具有50nm至100nm的平均粒度。 在另外的实施方案中，该装置包含包含聚合的链霉亲和素的捕获组分。 诊断装置在制备妊娠试剂盒中特别有用。

公开(公告)号：US07045342B2

公开(公告)日：2006-05-16

申请号：US10794516

申请日：2004-03-05

申请人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

发明人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

IPC分类号： C12M3/00

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

摘要： The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Disposed within the cell is a sample absorbent, a novel biphasic substrate and a reservoir, together capable of transporting an aqueous solution within the casing along a flow path extending from the sample inlet through the test volume and into the reservoir volume. The invention further comprises a method for detecting the presence of an analyte in a liquid sample using the device and a biphasic chromatographic material for carrying out the method.

公开(公告)号：US06767714B2

公开(公告)日：2004-07-27

申请号：US09951007

申请日：2001-09-12

申请人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

发明人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

IPC分类号： G01N33543

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

摘要： The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Disposed within the cell is a sample absorbent, a novel biphasic substrate and a reservoir, together capable of transporting an aqueous solution within the casing along a flow path extending from the sample inlet through the test volume and into the reservoir volume. The invention further comprises a method for detecting the presence of an analyte in a liquid sample using the device and a biphasic chromatographic material for carrying out the method.

公开(公告)号：US06319676B1

公开(公告)日：2001-11-20

申请号：US08432894

申请日：1995-05-02

申请人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

发明人： Albert Nazareth ,  Mary Beth Boyle ,  Yea-Shun Cheng

IPC分类号： G01N33558

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

摘要： The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Disposed within the cell is a sample absorbent, a novel biphasic substrate and a reservoir, together capable of transporting an aqueous solution within the casing along a flow path extending from the sample inlet through the test volume and into the reservoir volume. The invention further comprises a method for detecting the presence of an analyte in a liquid sample using the device and a biphasic chromatographic material for carrying out the method.

摘要翻译： 本发明提供了用于检测液体样品中分析物的存在的改进的测试池。 该装置具有限定液体样品入口，储存器容积，测试体积和在测试体积处通过壳体的窗口的细长壳体。 在细胞内设置的是样品吸收剂，新颖的双相基底和储存器，它们一起能够沿着从样品入口延伸穿过测试体积并进入储存容积的流动路径输送壳体内的水溶液。 本发明还包括使用该装置和用于执行该方法的双相色谱材料来检测液体样品中分析物的存在的方法。

公开(公告)号：US5739041A

公开(公告)日：1998-04-14

申请号：US432890

申请日：1995-05-02

申请人： Albert Nazareth ,  Yea-Shun Cheng ,  Mary Beth Boyle

发明人： Albert Nazareth ,  Yea-Shun Cheng ,  Mary Beth Boyle

IPC分类号： G01N33/493 ,  B01L3/00 ,  B01L9/00 ,  G01N33/543 ,  G01N33/558 ,  G01N37/00 ,  G01N33/53

CPC分类号： G01N33/558 ,  B01L3/5023 ,  B01L2200/141 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L9/52 ,  Y10S435/97 ,  Y10S436/807 ,  Y10S436/81

摘要： The invention is an improved single-step test device for detecting the presence of a pre-selected analyte in a urine stream. The device has a hollow outer casing and an assay material disposed within the casing. The outer casing defines: a urine inlet port; a viewing window; and at least one drainage vent spaced about the urine inlet port. The assay material is a sorptive material defining: a urine sample application region adjacent to, and in fluid communication with the urine inlet port; a capture region adjacent to the viewing window; and a fluid flow path for transporting liquid sample between the urine sample application region and the analyte capture region. The drainage vent is located to permit excess urine entering the casing from the urine stream to exit the casing thereby to minimize hydraulic pressure induced flooding of the assay material disposed within the casing and to reduce the frequency of false test results.

摘要翻译： 本发明是改进的单步测试装置，用于检测尿流中预选分析物的存在。 该装置具有中空的外壳和设置在壳体内的测定材料。 外壳定义：尿液入口; 一个观察窗; 以及至少一个与尿液入口隔开的排水口。 测定材料是吸附材料，其定义为与尿液入口相邻并且与尿液入口端口流体连通的尿样应用区域; 与观察窗相邻的捕获区域; 以及用于在尿液样品施加区域和分析物捕获区域之间输送液体样品的流体流动路径。 排水口位于允许从尿流进入套管的多余的尿液排出外壳，从而最小化设置在外壳内的测定材料的液压引起的淹水并减少假试验结果的频率。

公开(公告)号：US09939385B2

公开(公告)日：2018-04-10

申请号：US13229156

申请日：2011-09-09

申请人： Albert Nazareth ,  Andy Sturman ,  Benedict Zin ,  Yea-Shun Cheng ,  Henry Bell ,  Shang Li

发明人： Albert Nazareth ,  Andy Sturman ,  Benedict Zin ,  Yea-Shun Cheng ,  Henry Bell ,  Shang Li

IPC分类号： G01N21/84

CPC分类号： G01N21/8483

摘要： Systems, methods, and test kits for monitoring and detecting variation in an analyte level in a fluid sample from an individual variation using a uniquely determined analyte threshold value. In one implementation, luteinizing hormone is the monitored analyte and is compared with the determined threshold value to predict the onset of ovulation for the individual.