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公开(公告)号：US08035816B2
公开(公告)日：2011-10-11
申请号：US12295845
申请日：2007-04-10
申请人： Albert Randow , Helmut Dandl , Hans Krause
发明人： Albert Randow , Helmut Dandl , Hans Krause
IPC分类号： G01N21/59
CPC分类号： G01N21/274 , G01J3/02 , G01J3/0232 , G01J3/42 , G01J2001/4242 , G01N21/3518
摘要： In a method and apparatus for measuring the optical absorption of samples having a light source (1), a photoelectric converter (8), a measurement beam path extending between the light source (1) and the converter (8), in which path the sample to be examined is arranged, a reference beam path extending between the light source (1) and the converter (8), in which path a reference sample is arranged, and a motor-driven chopper disc (10), the chopper disc (10) is configured with a first number of first openings (15) unblocking only the measurement beam path and a second number of second openings (16) unblocking only the path for the reference beam. A lock-in amplifier (21) and a device (17) for synchronising the lock-in amplifier (21) with the chopper disc (10) is connected to the converter (8) and an evaluation circuit (26) establishes the quotient of the transmitted intensity of the reference beam path detected by the converter (8) and the transmitted intensity of the measurement beam path detected by the converter (8) as a measurement for the concentration of the sample in such a way that the decrease in the intensity of the beam by absorption leads to an increase in sensitivity.
摘要翻译： 在用于测量具有光源（1）的样品的光吸收的方法和装置中，光电转换器（8），在光源（1）和转换器（8）之间延伸的测量光束路径，其中路径 布置要检查的样本，在光源（1）和转换器（8）之间延伸的参考光束路径，其中布置参考样本的路径，以及电动驱动的斩波盘（10），斩波盘 10）配置有仅解除测量光束路径的第一数量的第一开口（15）和仅解除参考光束的路径的第二数量的第二开口（16）。 锁定放大器（21）和用于使锁定放大器（21）与斩波盘（10）同步的装置（17）连接到转换器（8），并且评估电路（26）建立 由转换器（8）检测的参考光束路径的透射强度和由转换器（8）检测的测量光束路径的透射强度作为样品浓度的测量，使得强度的降低 通过吸收导致光束的增加。
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公开(公告)号：US20090168064A1
公开(公告)日：2009-07-02
申请号：US12295845
申请日：2007-04-10
申请人： Albert Randow , Helmut Dandl , Hans Krause
发明人： Albert Randow , Helmut Dandl , Hans Krause
IPC分类号： G01N21/59
CPC分类号： G01N21/274 , G01J3/02 , G01J3/0232 , G01J3/42 , G01J2001/4242 , G01N21/3518
摘要： In a method and apparatus for measuring the optical absorption of samples having a light source (1), a photoelectric converter (8), a measurement beam path extending between the light source (1) and the converter (8), in which path the sample to be examined is arranged, a reference beam path extending between the light source (1) and the converter (8), in which path a reference sample is arranged, and a motor-driven chopper disc (10), the chopper disc (10) is configured with a first number of first openings (15) unblocking only the measurement beam path and a second number of second openings (16) unblocking only the path for the reference beam. A lock-in amplifier (21) and a device (17) for synchronising the lock-in amplifier (21) with the chopper disc (10) is connected to the converter (8) and an evaluation circuit (26) establishes the quotient of the transmitted intensity of the reference beam path detected by the converter (8) and the transmitted intensity of the measurement beam path detected by the converter (8) as a measurement for the concentration of the sample in such a way that the decrease in the intensity of the beam by absorption leads to an increase in sensitivity.
摘要翻译： 在用于测量具有光源（1）的样品的光吸收的方法和装置中，光电转换器（8），在光源（1）和转换器（8）之间延伸的测量光束路径，其中路径 布置要检查的样本，在光源（1）和转换器（8）之间延伸的参考光束路径，其中布置参考样本的路径，以及电动驱动的斩波盘（10），斩波盘 10）配置有仅解除测量光束路径的第一数量的第一开口（15）和仅解除参考光束的路径的第二数量的第二开口（16）。 锁定放大器（21）和用于使锁定放大器（21）与斩波盘（10）同步的装置（17）连接到转换器（8），并且评估电路（26）建立 由转换器（8）检测的参考光束路径的透射强度和由转换器（8）检测的测量光束路径的透射强度作为样品浓度的测量，使得强度的降低 通过吸收导致光束的增加。
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公开(公告)号：US4996876A
公开(公告)日：1991-03-05
申请号：US450034
申请日：1989-12-13
申请人： Hans Krause , Albert Randow
发明人： Hans Krause , Albert Randow
摘要： A microrheoscopic detector for gases including two thin wire resistance thermometers and a heating conductor disposed between the two resistance thermometers, the resistance thermometers being positioned in the area of influence of the heating conductor and spaced therefrom in a definite spatial fixation, the heating conductor having a span transverse gas flow path and comprising a plurality of parallel conductor legs laying in the span in the same plane as the resistance thermometers.
摘要翻译： 一种用于气体的微环镜检测器，包括两根细线电阻温度计和设置在两个电阻温度计之间的加热导体，电阻温度计被定位在加热导体的影响区域中并与其隔开一定的空间固定，加热导体具有 跨越横向气体流动路径并且包括布置在与电阻温度计相同的平面中的跨度中的多个平行导体腿。
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4.发明授权Process and apparatus for the detection of toxicity in surface waters as well as drinking water and industrial water 失效检测表面水中的毒素作为饮用水和工业用水的过程和装置
公开(公告)号：US5225333A
公开(公告)日：1993-07-06
申请号：US190576
申请日：1988-05-05
申请人： Hans Krause , Helmut Maske
发明人： Hans Krause , Helmut Maske
CPC分类号： C12Q1/025 , G01N21/6408 , G01N33/1866 , G01N2021/6413 , G01N2021/6482 , G01N21/85 , G01N2520/00 , Y10S435/808 , Y10S435/946 , Y10S436/805 , Y10T436/117497
摘要： This invention provides a process and an apparatus for the detection of toxicity in surface waters, by which the fluorescence of a water sample is measured in that the correlation, especially the ratio, between the prompt fluorescence and retarded fluorescence of the water sample is determined, which contains a toxicity-sensitive bioorganism. The apparatus comprises a combination of a first fluorescence measuring means for measuring prompt fluorescence and a second fluorescence measuring means for measuring retarded fluorescence as well as a signal correlation means for correlating the output signals of two fluorescence measuring means with each other to form an output quantity indicating the toxicity of the water sample.
摘要翻译： 本发明提供了一种用于检测表面水中的毒性的方法和装置，通过该方法测量水样品的荧光，因为确定了水样品的迅速荧光和延迟荧光之间的相关性，特别是比例， 其中含有毒性敏感的生物体。 该装置包括用于测量迅速荧光的第一荧光测量装置和用于测量延迟荧光的第二荧光测量装置以及用于将两个荧光测量装置的输出信号彼此相关联的信号相关装置的组合，以形成输出量 表明水样的毒性。
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5.发明授权Pharmaceutical formulations: liposomes incorporating aromatic polyene antibiotics 失效药物制剂：掺入芳香多烯抗生素的脂质体
公开(公告)号：US4999199A
公开(公告)日：1991-03-12
申请号：US269638
申请日：1988-11-10
IPC分类号： A61K9/127
摘要： The present invention involves a pharmaceutical formulation comprising a liposome having a therapeutically effective concentration of an aromatic polyene macrolide antibiotic. The aromatic polyene macrolide antibiotic usable in the practice of the present invention is selected from the group consisting of candicidin, hamycin, aurefungin, ascosin, ayfattin, azacolutin, DJ400-B, trichomycin, levorin, heptamycin, candimycin or perimycin. The most preferred aromatic polyene macrolide antibiotic is candicidin. An important aspect of the present invention is a method for treating disseminated fungal infection in an animal comprising administering to an animal such as a human a pharmaceutical formulation comprising a liposome having a therapeutically effective amount of aromatic polyene macrolide antibiotic as described above. The preferred method of such administering is parenteral and the therapeutically effective amount is between about 1 mg/kg body weight and about 20 mg/kg body weight, more preferably between about 2.5 mg/kg body weight and about 6 mg/kg body weight. The parenteral administration is intravenous, intraarterial, subcutaneous, intramuscular, intralymphatic, intraperitoneal or intrapleural. The microorganisms which may be treated by the methods of the present invention comprise C. albicans, C. tropicalis, C. neoformans, aspergillus, cryptococcus, phycomycetes, fusarium, or trichosporin.
摘要翻译： 本发明涉及包含具有治疗有效浓度的芳族多烯大环内酯抗生素的脂质体的药物制剂。 可用于本发明实践中的芳香族多烯大环内酯类抗生素选自念珠菌素，马铃薯霉素，aurefungin，ascosin，ayfattin，azacolutin，DJ400-B，trichomycin，levorin，庚霉素，candimycin或perimycin。 最优选的芳香族多烯大环内酯类抗生素是水cand啶。 本发明的一个重要方面是用于治疗动物中播散性真菌感染的方法，包括向动物如人类施用包含具有治疗有效量的如上所述的芳族多烯大环内酯类抗生素的脂质体的药物制剂。 这种施用的优选方法是肠胃外，治疗有效量为约1mg / kg体重与约20mg / kg体重之间，更优选约2.5mg / kg体重至约6mg / kg体重。 肠胃外给药是静脉内，动脉内，皮下，肌内，淋巴内，腹膜内或胸膜内。 可以通过本发明的方法处理的微生物包括白色念珠菌，热带热带弧菌，新生隐球菌，曲霉菌，隐球菌属，菌纲菌，镰孢菌素或trichosporin。
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6.发明授权Method and apparatus for measuring a gas by exploiting the paramagnetic properties of the gas 失效通过利用气体的顺磁特性来测量气体的方法和装置
公开(公告)号：US4983913A
公开(公告)日：1991-01-08
申请号：US497929
申请日：1990-03-23
申请人： Hans Krause , Rudi Roess , Ulrich Modlinski
发明人： Hans Krause , Rudi Roess , Ulrich Modlinski
CPC分类号： G01N27/74 , G01N1/2214 , G01N2001/2261
摘要： A paramagnetic gas measuring device/instrument including an infrared radiator for irradiating diamagnetic members of the device and for creating a climate within a measuring chamber suitable to evaporate moisture from the members and a gas being analyzed.
摘要翻译： 一种顺磁性气体测量装置/仪器，其包括用于照射装置的抗磁性构件的红外辐射器，并且用于在测量室内产生适于蒸发来自构件的气体和被分析的气体的气候。
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公开(公告)号：US4881869A
公开(公告)日：1989-11-21
申请号：US195116
申请日：1988-05-17
CPC分类号： C21B7/18 , F27B1/20 , F27D3/0033 , F27D3/10 , F27D2003/105
摘要： In a throat stopper for shaft furnaces, in particular blast furnaces with two hoppers of which an upper hopper is rotatable through a drive device, the upper hopper is designed, by a stationary hood equipped with charging flap valves, as a sluice chamber to be closed pressureproof. For sealing the stationary hood relative to the rotatable upper hopper, there is disposed, at the hood, a peripheral flexible inflatable bellows. The bellows can be pressed against the wall of the upper hopper pneumatically or hydraulically. While material is being charged in the upper hopper, one of the charging valves is open and the bellows is pressureless. During, or shortly after, the charging, the uppr hopper is rotated. For filling the lower hopper, the valves of the upper hopper are closed, bellows is inflated, and the upper sluice chamber is pressurized.
摘要翻译： 在用于竖炉的喉部止动器中，特别是具有两个料斗的高炉，上料斗可以通过驱动装置旋转，上料斗通过装备有充气阀的固定罩设计为要关闭的闸室 防水。 为了相对于可旋转的上料斗密封固定罩，在罩处设置有外围柔性的可充气波纹管。 波纹管可以气动或液压地压在上料斗的壁上。 当材料在上料斗中充电时，其中一个充气阀打开，波纹管是无压力的。 在充电期间或不久之后，uppr料斗旋转。 为了填充下料斗，上料斗的阀关闭，波纹管膨胀，上闸室受压。
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公开(公告)号：US4987010A
公开(公告)日：1991-01-22
申请号：US411736
申请日：1989-09-25
申请人： Hans Krause , Helmut Stoll
发明人： Hans Krause , Helmut Stoll
摘要： A method for manufacturing a film resistor for use as a thermal conductivity detector, particularly for gas analyzers. The film resistor is composed of a carrier of insulating material and of a thin resistance layer, preferably composed of platinum, that is applied to the carrier by cathode sputtering in an atmosphere inert gas. The resistant layer and the carrier are cleaned proceeding from the metallized side using an argon sputtering process. The film resistor is then coated with at least one plasma-enhanced CVD layer for the purpose of protection against aggressive gases.
摘要翻译： 一种制造用作导热性检测器的薄膜电阻器的方法，特别是用于气体分析仪。 薄膜电阻器由绝缘材料的载体和优选由铂组成的薄电阻层构成，其通过阴极溅射在气氛惰性气体中施加到载体上。 使用氩气溅射方法从金属化侧清洗电阻层和载体。 然后将膜电阻器涂覆有至少一个等离子体增强CVD层，以防止侵蚀性气体。
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公开(公告)号：US4878655A
公开(公告)日：1989-11-07
申请号：US100526
申请日：1987-09-24
CPC分类号： C21B7/18 , F27B1/20 , F27D3/0033 , F27D3/10 , F27D2003/105
摘要： In a throat stopper for shaft furnaces, in particular blast furnaces with two hoppers of which an upper hopper is rotatable through a drive device, the upper hopper is designed, by means of a stationary hood equipped with charging flap valves, as a sluice chamber to be closed pressureproof. For sealing the stationary hood relative to the rotatable upper hopper, there is disposed, at the hood, a peripheral flexible inflatable bellows. The bellows can be pressed against the wall of the upper hopper pneumatically or hydraulically. While material is being charged in the upper hopper, one of the charging valves is open and the bellows is pressureless. During, or shortly thereafter, the charging, the upper hopper is rotated. For during the lower hopper, the valves of the upper hopper are closed, bellows is inflated, and the upper hopper is hopper are closed, bellows is inflated, and the upper sluice chamber is pressurized.
摘要翻译： 在用于竖炉的喉部止动器中，特别是具有两个料斗的高炉，其中上料斗可以通过驱动装置旋转，上料斗通过装有充气阀门的固定罩设计为闸门室 封闭防压。 为了相对于可旋转的上料斗密封固定罩，在罩处设置有外围柔性的可充气波纹管。 波纹管可以气动或液压地压在上料斗的壁上。 当材料在上料斗中充电时，其中一个充气阀打开，波纹管是无压力的。 在此期间，或之后不久，充电，上料斗旋转。 对于下料斗期间，上料斗的阀关闭，波纹管充气，上料斗料斗关闭，波纹管膨胀，上闸阀加压。
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公开(公告)号：US4872769A
公开(公告)日：1989-10-10
申请号：US267245
申请日：1988-11-04
申请人： Hans Krause , Rudi Ross , Helmut Koch
发明人： Hans Krause , Rudi Ross , Helmut Koch
摘要： In a friction bearing system for a rapidly rotating shaft of an apparatus for measuring the optical absorption of a sample under analysis by way of an optical radiation source projecting a beam on the sample, the chopper system for the periodical interruption of the beam includes a rotatably mounted chopper disk provided with light-admitting openings and a controlled-speed drive system, as well as a radiation detector for the light affected by the sample. Both ends of the shaft fixedly joined to the chopper disk are provided with pivots corresponding to bushes, one of which is held by a spider which is affixed to the housing part that holds the other bush. The spider is provided with a bore running at an angle to the shaft, and the longitudinal axis of this bore intersects the axis of rotation of the shaft. A magnet is held for longitudinal displacement in the bore and its field acts upon a ring disposed on the shaft in order to assure the quiet and wear-free spinning of the chopper disk.
摘要翻译： 在用于通过在样品上投射光束的光辐射源测量分析中的样品的光吸收的装置的快速旋转轴的摩擦轴承系统中，用于波束的周期性中断的斩波器系统包括可旋转 具有光入口的安装的斩波盘和受控速度驱动系统，以及用于受样品影响的光的辐射探测器。 固定连接到斩波盘的轴的两端设置有对应于衬套的枢轴，其中一个由固定到保持另一个衬套的壳体部分的一个蜘蛛保持。 该蜘蛛设置有与轴成一定角度的孔，并且该孔的纵向轴线与轴的旋转轴线相交。 保持磁体在孔中的纵向位移，并且其磁场作用在设置在轴上的环上，以确保斩波盘的安静和无磨损的旋转。
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