公开(公告)号：US07754484B2

公开(公告)日：2010-07-13

申请号：US11595538

申请日：2006-11-10

申请人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

发明人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

IPC分类号： C12N5/02

CPC分类号： C12N5/0037 ,  C12N2500/36 ,  C12N2500/72 ,  C12N2500/76 ,  C12N2500/82 ,  C12N2500/90

摘要： The disclosed invention relates to the use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultivation and, more particularly, as a substitute for foetal bovine serum. In one aspect, the esters comprise more than 50 mol-% of physiologically active fatty acids containing 16 to 24 carbon atoms and 2 to 5 double bonds as the acid component and a lower C1-4 alcohol, preferably ethanol, or a sterol as ester component. In another aspect, the esters comprise a transesterification product of natural or synthetic oils or a mixture of such oils having greater than 50 mol-% of unsaturated, physiologically active fatty acids, based on the acyl group, and a lower C1-4 alcohol or a sterol. In a further aspect, the esters are used together with sterols, phospholipids and/or vegetable proteins or are liposomally encapsulated.

摘要翻译： 所公开的发明涉及使用不饱和生理活性脂肪酸的酯作为细胞培养的营养培养基，更特别地，作为胎牛血清的替代物。 一方面，酯包含大于50mol％的含有16-24个碳原子和2-5个双键的生理活性脂肪酸作为酸组分和一个低级C 1-4醇，优选乙醇或作为酯的固醇 零件。 在另一方面，酯包括天然或合成油的酯交换产物或具有大于50摩尔％的基于酰基的不饱和的生理活性脂肪酸的这种油的混合物，以及较低的C 1-4醇或 一种甾醇 在另一方面，酯与甾醇，磷脂和/或植物蛋白质一起使用或被脂质体包封。

公开(公告)号：US20070231902A1

公开(公告)日：2007-10-04

申请号：US11595538

申请日：2006-11-10

申请人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

发明人： Albert Strube ,  Claudia Scholz ,  Jochen Seifert ,  Christophe Carite ,  Christophe Sicre ,  Valerie Eychenne

IPC分类号： C12N5/02

CPC分类号： C12N5/0037 ,  C12N2500/36 ,  C12N2500/72 ,  C12N2500/76 ,  C12N2500/82 ,  C12N2500/90

摘要： The disclosed invention relates to the use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultivation and, more particularly, as a substitute for foetal bovine serum. In one aspect, the esters comprise more than 50 mol-% of physiologically active fatty acids containing 16 to 24 carbon atoms and 2 to 5 double bonds as the acid component and a lower C1-4 alcohol, preferably ethanol, or a sterol as ester component. In another aspect, the esters comprise a transesterification product of natural or synthetic oils or a mixture of such oils having greater than 50 mol-% of unsaturated, physiologically active fatty acids, based on the acyl group, and a lower C1-4 alcohol or a sterol. In a further aspect, the esters are used together with sterols, phospholipids and/or vegetable proteins or are liposomally encapsulated.

摘要翻译： 所公开的发明涉及使用不饱和生理活性脂肪酸的酯作为细胞培养的营养培养基，更特别地，作为胎牛血清的替代物。 在一个方面，酯包含大于50mol％的含有16-24个碳原子和2-5个双键的生理活性脂肪酸作为酸组分和较低C 1-4醇， 优选乙醇，或作为酯组分的甾醇。 另一方面，酯包括天然或合成油的酯交换产物或具有大于50摩尔％的基于酰基的不饱和的生理活性脂肪酸的这种油的混合物，以及较低的C 1 -4醇或甾醇。 在另一方面，酯与甾醇，磷脂和/或植物蛋白质一起使用或被脂质体包封。

公开(公告)号：US20080033191A1

公开(公告)日：2008-02-07

申请号：US11880928

申请日：2007-07-25

申请人： Ulrich Schoerken ,  David Melchior ,  Jochen Seifert ,  Carolin Meyer ,  Valerie Eychenne ,  Christiane Richard-Elsner ,  Horst Josten ,  Jean Rigal ,  Bernhard Gutsche ,  Albert Strube

发明人： Ulrich Schoerken ,  David Melchior ,  Jochen Seifert ,  Carolin Meyer ,  Valerie Eychenne ,  Christiane Richard-Elsner ,  Horst Josten ,  Jean Rigal ,  Bernhard Gutsche ,  Albert Strube

IPC分类号： C07C51/00

CPC分类号： C07C29/88 ,  A61K47/10 ,  C07C31/225

摘要： The invention describes a process for the production of glycerol of providing a vegetable oil or fat as starting material, obtaining crude glycerol from the vegetable oil or fat, and treating the crude glycerol with a reducing agent. The present invention also describes a process for the production of a medicament or pharmaceutical composition, the medicament or composition formed by combining glycerol and at least one pharmaceutically active ingredient. The present invention also describes a pharmaceutical composition or medicament composed of glycerol obtained by way of the invention and a pharmaceutically active ingredient, which compositions forms very little glyceraldehyde and dihydroxyacetone during storage.

摘要翻译： 本发明描述了一种生产以植物油或脂肪为原料的甘油的制备方法，从植物油或脂肪中获得粗甘油，并用还原剂处理粗甘油。 本发明还描述了制备药物或药物组合物的方法，所述药物或组合物通过将甘油与至少一种药物活性成分组合而形成。 本发明还描述了由通过本发明获得的甘油和药物活性成分组成的药物组合物或药物，该组合物在储存期间形成非常少的甘油醛和二羟基丙酮。