公开(公告)号：US09646812B2

公开(公告)日：2017-05-09

申请号：US14234772

申请日：2012-07-25

申请人： Oliver J. Schmitz ,  Volker Wulf ,  Lukas Hyzak ,  Michaela Wirtz ,  David Melchior ,  Hans Willi Kling ,  Siegmar Gäb ,  Ursula Gäb

发明人： Oliver J. Schmitz ,  Volker Wulf ,  Lukas Hyzak ,  Michaela Wirtz ,  David Melchior ,  Hans Willi Kling ,  Siegmar Gäb

IPC分类号： H01J49/00 ,  H01J49/04 ,  G01N1/38 ,  H01J49/16

CPC分类号： H01J49/0031 ,  G01N1/38 ,  H01J49/0036 ,  H01J49/0418 ,  H01J49/0459 ,  H01J49/164

摘要： The present invention is concerned with a method of preparing a MALDI sample, the method comprising the steps of: (a) mixing a solid sample precursor comprising sample and matrix to form a solid sample mixture; (b) applying the solid sample mixture to a sample cavity of a MALDI target; and (c) compressing the solid sample mixture in the sample cavity so as to form a MALDI sample surface for laser desorption. The present invention also provides a MALDI target comprising a sample cavity for receiving a MALDI sample, the sample cavity having (a) a desorption end portion comprising an aperture, such that a portion of the MALDI sample exposed at the aperture is in use subjected to laser desorption; and wherein the sample cavity also has (b) a compression end portion adapted to permit compression of a solid sample mixture towards the desorption end portion in the sample cavity by applying a compression force to the solid sample mixture via the compression end portion.

公开(公告)号：US20080033191A1

公开(公告)日：2008-02-07

申请号：US11880928

申请日：2007-07-25

申请人： Ulrich Schoerken ,  David Melchior ,  Jochen Seifert ,  Carolin Meyer ,  Valerie Eychenne ,  Christiane Richard-Elsner ,  Horst Josten ,  Jean Rigal ,  Bernhard Gutsche ,  Albert Strube

发明人： Ulrich Schoerken ,  David Melchior ,  Jochen Seifert ,  Carolin Meyer ,  Valerie Eychenne ,  Christiane Richard-Elsner ,  Horst Josten ,  Jean Rigal ,  Bernhard Gutsche ,  Albert Strube

IPC分类号： C07C51/00

CPC分类号： C07C29/88 ,  A61K47/10 ,  C07C31/225

摘要： The invention describes a process for the production of glycerol of providing a vegetable oil or fat as starting material, obtaining crude glycerol from the vegetable oil or fat, and treating the crude glycerol with a reducing agent. The present invention also describes a process for the production of a medicament or pharmaceutical composition, the medicament or composition formed by combining glycerol and at least one pharmaceutically active ingredient. The present invention also describes a pharmaceutical composition or medicament composed of glycerol obtained by way of the invention and a pharmaceutically active ingredient, which compositions forms very little glyceraldehyde and dihydroxyacetone during storage.

摘要翻译： 本发明描述了一种生产以植物油或脂肪为原料的甘油的制备方法，从植物油或脂肪中获得粗甘油，并用还原剂处理粗甘油。 本发明还描述了制备药物或药物组合物的方法，所述药物或组合物通过将甘油与至少一种药物活性成分组合而形成。 本发明还描述了由通过本发明获得的甘油和药物活性成分组成的药物组合物或药物，该组合物在储存期间形成非常少的甘油醛和二羟基丙酮。

公开(公告)号：US20090197251A1

公开(公告)日：2009-08-06

申请号：US11810577

申请日：2007-06-06

申请人： David Melchior ,  Bert Poepping

发明人： David Melchior ,  Bert Poepping

IPC分类号： C12Q1/68

CPC分类号： C12Q1/68 ,  C12Q2563/185

摘要： The invention relates generally to product identification and, more particularly, to processes for marking products with nucleic acids to establish the identity and origin of the products, to track them and to determine their quantity in the event of blending or dilution with other products. The invention also relates to the use of nucleic acids which code characters and character sequences for marking products and to products containing nucleic acids which code characters and character sequences.

摘要翻译： 本发明一般涉及产品鉴定，更具体地，涉及用核酸标记产品以确定产品的身份和来源，跟踪它们并在与其它产品混合或稀释的情况下确定其数量的方法。 本发明还涉及编码用于标记产物的字符和字符序列的核酸以及含有编码字符和字符序列的核酸的产物的用途。