公开(公告)号：US20190315836A1

公开(公告)日：2019-10-17

申请号：US16403862

申请日：2019-05-06

申请人： Albumedix Ltd

发明人： Karen Ann Delahay

IPC分类号： C07K14/765

摘要： The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

公开(公告)号：US20210070839A1

公开(公告)日：2021-03-11

申请号：US16820421

申请日：2020-03-16

申请人： Albumedix Ltd

发明人： Karen Ann Delahay ,  Christopher John Arthur Finnis ,  Karl Michael Nicholls

IPC分类号： C07K14/765 ,  A61K47/64 ,  A61K38/38 ,  A61K47/42

摘要： The present invention relates to conjugation-competent albumins and albumin-related polypeptides, and their conjugates with at least one moiety, and to polynucleotides encoding them.

公开(公告)号：US10934341B2

公开(公告)日：2021-03-02

申请号：US16598939

申请日：2019-10-10

申请人： Albumedix Ltd

发明人： Jason Cameron ,  Karen Ann Delahay ,  Jens Erik Nielsen ,  Andrew Plumridge ,  Jan Terje Andersen

IPC分类号： C07K14/765 ,  A61K39/385 ,  A61K38/38

摘要： The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

公开(公告)号：US20230039076A1

公开(公告)日：2023-02-09

申请号：US17656728

申请日：2022-03-28

申请人： Albumedix Ltd

发明人： Karen Ann Delahay ,  Christopher John Arthur Finnis ,  Karl Michael Nicholls

IPC分类号： C07K14/765 ,  A61K47/64 ,  A61K38/38 ,  A61K47/42

摘要： The present invention relates to conjugation-competent albumins and albumin-related polypeptides, and their conjugates with at least one moiety, and to polynucleotides encoding them.

公开(公告)号：US10329340B2

公开(公告)日：2019-06-25

申请号：US15915977

申请日：2018-03-08

申请人： Albumedix Ltd

发明人： Karen Ann Delahay

IPC分类号： C07K14/765

摘要： The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.