公开(公告)号：US10696732B2

公开(公告)日：2020-06-30

申请号：US15979319

申请日：2018-05-14

申请人： Albumedix Ltd

发明人： Darrell Sleep ,  Andrew Plumridge ,  Jason Cameron ,  Inger Sandlie ,  Jan Terje Andersen ,  Esben Peter Friis

IPC分类号： A61K38/38 ,  A61K47/48 ,  C07K14/76 ,  C12P21/06 ,  C12P21/04 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07H21/04 ,  C07K14/765 ,  C07K14/54 ,  A61K45/06

摘要： The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.

公开(公告)号：US10934341B2

公开(公告)日：2021-03-02

申请号：US16598939

申请日：2019-10-10

申请人： Albumedix Ltd

发明人： Jason Cameron ,  Karen Ann Delahay ,  Jens Erik Nielsen ,  Andrew Plumridge ,  Jan Terje Andersen

IPC分类号： C07K14/765 ,  A61K39/385 ,  A61K38/38

摘要： The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.