公开(公告)号：US20200172756A1

公开(公告)日：2020-06-04

申请号：US16426506

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Chung-Yuan Chiang ,  Newton T. Samuel ,  Richard Govan ,  Ciara Dauenhauer

IPC: C09D133/02 ,  B29D11/00

Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.

公开(公告)号：US11099300B2

公开(公告)日：2021-08-24

申请号：US16426451

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Hyeju Kim ,  Ciara Dauenhauer

IPC: G02B1/04 ,  C09D133/08 ,  G02B1/10 ,  A61L12/04

Abstract: The invention is generally related to a method for producing, in a consistent manner, SiHy contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, the base coating is formed by having two solution coating steps separated by at least one rinsing step with a buffered saline or pH controlled solution. The durability of the hydrogel coatings on resultant silicone hydrogel contact lenses can be improved significantly and will not vary with the optical power (i.e., the center thickness) of the SiHy contact lens under coating.

公开(公告)号：US20200174160A1

公开(公告)日：2020-06-04

申请号：US16426451

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Hyeju Kim ,  Ciara Dauenhauer

IPC: G02B1/04 ,  C09D133/08 ,  A61L12/04 ,  G02B1/10

Abstract: The invention is generally related to a method for producing, in a consistent manner, SiHy contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, the base coating is formed by having two solution coating steps separated by at least one rinsing step with a buffered saline or pH controlled solution. The durability of the hydrogel coatings on resultant silicone hydrogel contact lenses can be improved significantly and will not vary with the optical power (i.e., the center thickness) of the SiHy contact lens under coating.

公开(公告)号：US11459479B2

公开(公告)日：2022-10-04

申请号：US16426506

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Chung-Yuan Chiang ,  Newton T. Samuel ,  Richard Govan ,  Ciara Dauenhauer

IPC: C09D133/02 ,  B29D11/00 ,  B29K683/00 ,  G02C7/04

Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.

公开(公告)号：US20220032564A1

公开(公告)日：2022-02-03

申请号：US17385987

申请日：2021-07-27

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Ciara Dauenhauer ,  Chung-Yuan Chiang ,  Paul William Oyler ,  Robert Carey Tucker

IPC: B29D11/00 ,  G02C7/04 ,  C09D133/10 ,  C09D133/08

Abstract: The invention is related to a coated contact lens, especially a coated silicone hydrogel contact lens, which comprises an anterior surface, an opposite posterior surface, and a layered structural configuration from the anterior surface to the posterior surface. The layered structural configuration comprises an outer anterior surface hydrogel layer, an inner layer, and an outer posterior surface hydrogel layer. The inner layer is a lens bulk material. The coated contact lens has a superior lens surface softness and a good lens surface hydrophilicity while optionally having a desirably-lower polyquaternium-1 uptake.