公开(公告)号：US20220137263A1

公开(公告)日：2022-05-05

申请号：US17572794

申请日：2022-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B05D5/00 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20210130648A1

公开(公告)日：2021-05-06

申请号：US17146181

申请日：2021-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US20240399686A1

公开(公告)日：2024-12-05

申请号：US18678966

申请日：2024-05-30

Applicant: Alcon Inc.

Inventor： Zahra Bassampour ,  Steve Yun Zhang ,  Lilanni Perez ,  Ashanti Smith ,  Nicholas Gober ,  Ya-Wen Chang ,  Newton T. Samuel ,  Richard Charles Breitkopf

IPC: B29D11/00 ,  B29K23/00 ,  B29K83/00 ,  B29K105/00 ,  B29K105/20 ,  G02C7/04

Abstract: The invention provides a method for producing delamination-resistant embedded contact lenses involving use of a mold set in two-curing steps and a special lens-forming composition for forming a bulk hydrogel material for embedding a crosslinked polymeric insert. The mold set consists of three mold halves, one of which is used twice, the first time for molding an insert from an insert-forming composition and the second time for an embedded contact lens with the molded insert embedded therein from the special lens-forming composition that a vinylic crosslinking agent and or organic solvent both of which independent of each other can swell an insert by a moderate swelling degree. The resultant embedded hydrogel contact lenses can be free of deformation and delamination.

公开(公告)号：US20200324314A1

公开(公告)日：2020-10-15

申请号：US16843989

申请日：2020-04-09

Applicant: Alcon Inc.

Inventor： Newton T. Samuel ,  Yongxing Qiu ,  John Dallas Pruitt ,  Matthew McCollum

IPC: B05D1/18 ,  G02B1/18 ,  C09D5/00 ,  C09D133/02

Abstract: The invention is generally related to a method for producing, in a consistent manner, contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material having azetidinium groups onto a base coating of a polyanionic polymer on a contact lens at a relatively low temperature (e.g., from about 40° C. to about 60° C.). The coating temperature for forming a durable hydrogel coating on top of the base coating of a contact lens can be significantly lowered by raising, in situ, the pH (to about 9.5 or higher) of a reactive coating solution which contains the hydrophilic polymeric material having azetidinium groups.

公开(公告)号：US20240399627A1

公开(公告)日：2024-12-05

申请号：US18678872

申请日：2024-05-30

Applicant: Alcon Inc.

Inventor： Ya-Wen Chang ,  Newton T. Samuel ,  Steve Yun Zhang ,  Feng Jing

IPC: B29C39/02 ,  B29C33/42 ,  B29C33/56 ,  B29C39/00 ,  B29C39/10 ,  B29C39/26 ,  B29D11/00 ,  B29K83/00 ,  B29K105/00 ,  B29K105/24 ,  B29L11/00

Abstract: The invention provides a method for producing embedded contact lenses involving steps of use of a set of 3 mold halves in two-curing steps. One of the 3 mold halves have been used twice, the first time for molding an insert and the second time for molding the embedded hydrogel contact lens. The twice-used mold half has been treated with a corona plasma or a vacuum UV in a central circular area of its molding surface having a diameter equal to or smaller than the diameter of the insert to ensure that the molded insert consistently adhered to the twice-used mold half. The method also comprises a step of forming a reactive polysiloxane coating that is covalently attached onto the back or front surface of a molded insert adhered on the twice-used mold half before molding the embedded contact lens in the 2nd curing step.

公开(公告)号：US20240288712A1

公开(公告)日：2024-08-29

申请号：US18588225

申请日：2024-02-27

Applicant: Alcon Inc.

Inventor： Ethan Leveillee ,  Joseph Michael Lindacher ,  David Borja ,  Ying Pi ,  Newton T. Samuel ,  Ya-Wen Chang

IPC: G02C7/04

CPC classification number: G02C7/04

Abstract: A bi-layer contact lens having an insert embedded in a bulk hydrogel material. The insert comprises at least one peripheral edge, wherein the peripheral edge of the insert is configured to provide improved lens performance by selective application of at least one design parameter selected from width, angle, shape configuration, and combinations thereof the peripheral edge of the insert.

公开(公告)号：US11459479B2

公开(公告)日：2022-10-04

申请号：US16426506

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Chung-Yuan Chiang ,  Newton T. Samuel ,  Richard Govan ,  Ciara Dauenhauer

IPC: C09D133/02 ,  B29D11/00 ,  B29K683/00 ,  G02C7/04

Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.

公开(公告)号：US20240399685A1

公开(公告)日：2024-12-05

申请号：US18678916

申请日：2024-05-30

Applicant: Alcon Inc.

Inventor： Richard Charles Breitkopf ,  Newton T. Samuel ,  Ya-Wen Chang ,  Zahra Bassampour ,  Steve Yun Zhang

IPC: B29D11/00 ,  B29C33/42 ,  B29C39/00 ,  B29C39/02 ,  B29C39/10 ,  B29C39/26 ,  B29K83/00 ,  B29K105/00 ,  B29K683/00 ,  B29L11/00

Abstract: The invention provides a method for producing embedded contact lenses involving a mold set in a two-curing-step process and a fast-curing SiHy lens formulation. The mold set consists of three mold halves, one of which is used twice, the first time for molding an insert from an insert-forming composition and the second time for an embedded contact lens with the molded insert embedded therein from the fast curing SiHy lens formulation that comprises a N,N-dialkylacrylamide, a hydrophilic (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker and being free of any siloxane-containing vinylic monomer.

公开(公告)号：US20240399684A1

公开(公告)日：2024-12-05

申请号：US18678833

申请日：2024-05-30

Applicant: Alcon Inc.

Inventor： Newton T. Samuel ,  Ya-Wen Chang ,  Richard Charles Breitkopf ,  Augustine Twum Kumi ,  Steve Yun Zhang ,  David Borja ,  Ethan Leveillee ,  Joseph Michael Lindacher

IPC: B29D11/00 ,  B29C35/08 ,  B29K105/24 ,  B29L11/00 ,  G02B1/04

Abstract: The invention provides a method for producing embedded diffractive contact lenses involving use of a mold set in two-curing steps. The mold set consists of three mold halves, one of which is used twice, the first time for molding a diffractive insert and the second time for an embedded contact lens with the molded diffractive insert embedded therein. The twice-used mold half has been treated with a corona plasma or a vacuum UV in a central circular area having a diameter equal to or smaller than the diameter of the insert to ensure that the molded insert consistently adheres to the twice-used mold half, even though the other mating insert mold half for molding the diffractive insert has a great tendency to bind strongly the molded insert due to the diffractive structure on its molding surface.

公开(公告)号：US20240176047A1

公开(公告)日：2024-05-30

申请号：US18436094

申请日：2024-02-08

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  B05D1/18 ,  B05D1/38 ,  B05D3/00 ,  B05D3/02 ,  B05D5/00 ,  B05D5/10 ,  B29D11/00 ,  B29K83/00 ,  B29K105/00 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/04

CPC classification number: G02B1/043 ,  B05D5/00 ,  B29D11/00038 ,  B29D11/00125 ,  B29D11/00865 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/049 ,  B05D1/18 ,  B05D1/38 ,  B05D3/002 ,  B05D3/02 ,  B05D5/10 ,  B29K2083/00 ,  B29K2105/0061 ,  C08L2201/10 ,  C08L2201/54 ,  G02B2207/109

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.