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公开(公告)号：US20050123571A1
公开(公告)日：2005-06-09
申请号：US10863012
申请日：2004-06-07
申请人： Aldo Rossini , Rita Bortell , Dale Greiner , John Mordes , Silvia Corvera , Leanne Wilson-Fritch , Malini Pandarpurkar , Helle Markholst , Lars Hornum
发明人： Aldo Rossini , Rita Bortell , Dale Greiner , John Mordes , Silvia Corvera , Leanne Wilson-Fritch , Malini Pandarpurkar , Helle Markholst , Lars Hornum
IPC分类号： A61K39/00 , C07H21/04 , C07K14/47 , C12N20060101 , C12N9/64 , C12Q1/68 , G01N33/50 , G01N33/564 , G01N33/574
CPC分类号： G01N33/574 , C07K14/4747 , G01N33/5079 , G01N33/564 , G01N2510/00
摘要： The present invention relates, at least in part, to methods of modulating apoptosis in cells, comprising contacting the cell with a compound that modulates the expression, post-translational modification, or activity of Ian4, leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60. The subject methods can be used to treat a variety of different disorders, for example, autoimmune disease and neoplasia. The invention also pertains to methods for identifying compounds that modulates the activity of Ian-4, leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60.
摘要翻译： 本发明至少部分地涉及调节细胞凋亡的方法，包括使细胞与调节Ik4，130kD的富含亮氨酸的蛋白，GRP78的表达，翻译后修饰或活性的化合物接触， GRP94或hsp60。 本发明方法可用于治疗各种不同的疾病，例如自身免疫性疾病和瘤形成。 本发明还涉及用于鉴定调节Ik-4，富含亮氨酸的富含130kD的蛋白质，GRP78，GRP94或hsp60的活性的化合物的方法。
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公开(公告)号：US20060035301A1
公开(公告)日：2006-02-16
申请号：US11044652
申请日：2005-01-26
IPC分类号： C12Q1/48
CPC分类号： C12Q1/485 , G01N2500/00 , G01N2500/02 , G01N2500/04
摘要： Methods of identifying AMPK or AK modulators are provided. In particular, methods that feature identifying modulators of AK and its associated substrates (including AMP, ATP or AMP and ATP) or AMPK or activities associated therewith, are provided. Therapeutic methods utilizing compounds identified according to the methods of the invention are also provided.
摘要翻译： 提供了鉴定AMPK或AK调节剂的方法。 特别地，提供了鉴定AK及其相关底物（包括AMP，ATP或AMP和ATP）或AMPK或与其相关的活性的调节剂特征的方法。 还提供了利用根据本发明方法鉴定的化合物的治疗方法。
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