公开(公告)号：US20240101681A1

公开(公告)日：2024-03-28

申请号：US18039945

申请日：2021-12-01

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Felix Leejia YEH ,  Michael F. WARD ,  Robert PAUL ,  Hua LONG ,  Yijie LIAO

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/286 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505

Abstract: The present disclosure is generally directed to the use of antibodies that specifically bind one or more epitopes within a sortilin protein, e.g., human sortilin or mammalian sortilin, for treating and/or delaying progression of a disease, disorder, or injury in an individual in need thereof.

公开(公告)号：US20240329054A1

公开(公告)日：2024-10-03

申请号：US18656427

申请日：2024-05-06

Applicant: Alector LLC

Inventor： Robert PAUL ,  Michael F. WARD ,  Felix Leejia YEH ,  Yijie LIAO ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: G01N33/68

CPC classification number: G01N33/6854 ,  G01N33/6896 ,  G01N2333/70503 ,  G01N2800/2821 ,  G01N2800/52

Abstract: The present disclosure relates generally to biomarkers of activity and/or therapeutic efficacy of anti-CD33 antibodies for the treatment of a disease or injury in an individual, as well as methods related thereto.

公开(公告)号：US20240132597A1

公开(公告)日：2024-04-25

申请号：US18532382

申请日：2023-12-07

Applicant: Alector LLC

Inventor： Robert PAUL ,  Sam JACKSON ,  Omer Rizwan SIDDIQUI ,  Michael F. WARD ,  Felix Leejia YEH ,  Julie Y. HUANG ,  Whedy WANG ,  Yijie LIAO ,  Brian C. MANGAL

IPC: C07K16/28 ,  A61P25/28 ,  G01N33/68

CPC classification number: C07K16/286 ,  A61P25/28 ,  G01N33/6896 ,  A61K2039/505 ,  G01N2800/2814 ,  G01N2800/52

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

公开(公告)号：US20230183341A1

公开(公告)日：2023-06-15

申请号：US17916728

申请日：2021-04-02

Applicant: Alector LLC

Inventor： Robert PAUL ,  Michael F. WARD ,  Hua LONG ,  Omer Rizwan SIDDIQUI ,  Arnon ROSENTHAL ,  Felix Leejia YEH ,  Sam JACKSON

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a TREM2 protein, e.g., human TREM2, for use in treating and/or delaying progression of a disease or injury in an individual in need thereof.