公开(公告)号：US20200223928A1

公开(公告)日：2020-07-16

申请号：US16741658

申请日：2020-01-13

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20200024348A1

公开(公告)日：2020-01-23

申请号：US16510773

申请日：2019-07-12

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Michael KURNELLAS ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230047941A1

公开(公告)日：2023-02-16

申请号：US17836644

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Michael KURNELLAS ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220251219A1

公开(公告)日：2022-08-11

申请号：US17721112

申请日：2022-04-14

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220185899A1

公开(公告)日：2022-06-16

申请号：US17534291

申请日：2021-11-23

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20250092144A1

公开(公告)日：2025-03-20

申请号：US18957413

申请日：2024-11-22

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220185898A1

公开(公告)日：2022-06-16

申请号：US17534270

申请日：2021-11-23

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20170210808A1

公开(公告)日：2017-07-27

申请号：US15285359

申请日：2016-10-04

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K31/7088 ,  C07K16/286 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/32

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240294650A1

公开(公告)日：2024-09-05

申请号：US17995189

申请日：2021-03-30

Applicant: Alector LLC

Inventor： Michael KURNELLAS ,  Santiago Viveros SALAZAR ,  Marina ROELL ,  Angie Grace YEE ,  Seung-Joo LEE ,  Tina SCHWABE ,  Maxime CHAPON ,  William Francis ESTACIO ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  G01N33/573

CPC classification number: C07K16/2863 ,  G01N33/573 ,  C07K2317/33 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/9121

Abstract: The present disclosure is generally directed to antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g. a mammalian MerTK or human MerTK, and use of such compositions in preventing, reducing risk, or treating a disease or disorder an individual in need thereof.

公开(公告)号：US20220348656A1

公开(公告)日：2022-11-03

申请号：US17836707

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Michael KURNELLAS ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.