公开(公告)号：US20250092144A1

公开(公告)日：2025-03-20

申请号：US18957413

申请日：2024-11-22

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230035072A1

公开(公告)日：2023-02-02

申请号：US17784579

申请日：2020-12-11

Applicant: Alector LLC

Inventor： Robert PAUL ,  Michael F. WARD ,  Hua LONG ,  Shiao-Ping LU ,  Omer Rizwan SIDDIQUI ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics. The present disclosure is further directed to the methods of treating and/or delaying the progression of a disease or injury in an individual by administering such antibodies.

公开(公告)号：US20220185898A1

公开(公告)日：2022-06-16

申请号：US17534270

申请日：2021-11-23

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210403540A1

公开(公告)日：2021-12-30

申请号：US17156153

申请日：2021-01-22

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL

IPC: C07K16/18 ,  A61K45/06

Abstract: The present disclosure generally relates to antigen-binding proteins (ABPs) that specifically bind to apolipoprotein E (ApoE), compositions comprising such ABPs, methods of using such ABPs, and methods of making such ABPs. In some embodiments, the ABPs provided herein bind lipidated ApoE4. In some embodiments, the lipidated ApoE4 is within a lipoprotein particle, and the ABPs therefore bind to a lipoprotein particle comprising ApoE4. Any suitable ABP may be used. In some embodiments, the ABP is an antibody. In some embodiments, the ABP is an alternative scaffold. The ABPs provided herein may be used for the prevention or treatment of any disease, condition or disorder associated with ApoE4 expression.

公开(公告)号：US20210121583A1

公开(公告)日：2021-04-29

申请号：US17088237

申请日：2020-11-03

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE

IPC: A61K49/00 ,  C07K16/28 ,  G01N21/64 ,  G01N33/533 ,  G01N33/542

Abstract: The present disclosure provides methods of screening for a sortilin binding antagonist. In some embodiments, the methods include incubating an agent with a sortilin protein and a sortilin ligand, where the sortilin protein and sortilin ligand are each attached to a member of a fluorescence donor/acceptor pair, exciting the fluorescence donor of the fluorescence donor/acceptor pair, and detecting fluorescence emitted by the fluorescence donor at a second wavelength and fluorescence emitted by the fluorescence acceptor at a third wavelength. A decrease in the ratio of the fluorescence emitted by the fluorescence acceptor at the third wavelength to the fluorescence emitted by the fluorescence donor at the second wavelength, as compared to the ratio in the absence of the agent, indicates that the agent is a sortilin binding antagonist.

公开(公告)号：US20190040130A1

公开(公告)日：2019-02-07

申请号：US16054680

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  IIaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190002560A1

公开(公告)日：2019-01-03

申请号：US15735947

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Kate MONROE ,  Helen LAM ,  Francesca AVOGADRI-CONNORS ,  Seung-Joo LEE ,  William MONTEITH ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20170210808A1

公开(公告)日：2017-07-27

申请号：US15285359

申请日：2016-10-04

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K31/7088 ,  C07K16/286 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/32

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240174746A1

公开(公告)日：2024-05-30

申请号：US18551162

申请日：2022-03-17

Applicant: ALECTOR LLC

Inventor： Eric BROWN ,  Angie Grace YEE ,  Tina SCHWABE ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240101681A1

公开(公告)日：2024-03-28

申请号：US18039945

申请日：2021-12-01

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Felix Leejia YEH ,  Michael F. WARD ,  Robert PAUL ,  Hua LONG ,  Yijie LIAO

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/286 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505

Abstract: The present disclosure is generally directed to the use of antibodies that specifically bind one or more epitopes within a sortilin protein, e.g., human sortilin or mammalian sortilin, for treating and/or delaying progression of a disease, disorder, or injury in an individual in need thereof.