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    Adaptive cardiac resynchronization therapy
    1.
    发明授权
    Adaptive cardiac resynchronization therapy 有权
    自适应心脏再同步治疗

    公开(公告)号：US08886307B2

    公开(公告)日：2014-11-11

    申请号：US13361635

    申请日：2012-01-30

    申请人： Aleksandre T. Sambelashvili ,  Thomas J. Mullen ,  Todd J. Sheldon

    发明人： Aleksandre T. Sambelashvili ,  Thomas J. Mullen ,  Todd J. Sheldon

    IPC分类号： A61N1/368

    CPC分类号： A61N1/3714 ,  A61N1/36514 ,  A61N1/36592 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/371

    摘要： Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.

    摘要翻译： 可以基于检测心脏的内在房室传导的替代指示来调整输送到患者心脏的心脏再同步治疗（CRT）。 在一些示例中，在将融合起搏刺激递送到后去除极化心室之后的预定时间段内，替代指示被确定为心脏的第一去极化心室的感觉事件。 在一些示例中，如果未检测到替代指示，则CRT从融合起搏配置切换到双心室起搏配置，并且如果检测到替代指示，则CRT保持在融合起搏配置中。

    Method for efficient delivery of dual site pacing
    9.
    发明授权
    Method for efficient delivery of dual site pacing 有权
    双位置起搏有效运送的方法

    公开(公告)号：US09037238B2

    公开(公告)日：2015-05-19

    申请号：US13301084

    申请日：2011-11-21

    申请人： Robert W. Stadler ,  Wade M. Demmer ,  Vincent E. Splett ,  Todd J. Sheldon

    发明人： Robert W. Stadler ,  Wade M. Demmer ,  Vincent E. Splett ,  Todd J. Sheldon

    IPC分类号： A61N1/00 ,  A61N1/368 ,  A61N1/37

    CPC分类号： A61N1/3684 ,  A61N1/368 ,  A61N1/3686 ,  A61N1/3712

    摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses to a first pacing site along a heart chamber and a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the electrodes. A sensing module measures an activation time at multiple pacing electrode sites along the heart chamber in response to delivering pacing pulses at the first pacing site. A controller is configured to identify a second pacing site from the plurality of pacing electrode sites in response to the activation times measured during pacing at the first site.

    摘要翻译： 用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号并将心脏起搏脉冲输送到沿着心脏室的第一起搏部位的电极和用于经由心脏起搏器将心脏起搏脉冲输送到患者心脏的治疗递送模块 电极。 响应于在第一起搏部位输送起搏脉冲，感测模块测量沿着心室的多个起搏电极部位的激活时间。 控制器被配置为响应于在第一站点的起搏期间测量的激活时间，从多个起搏电极位置识别第二起搏部位。

    LV threshold measurement and capture management
    10.
    发明授权
    LV threshold measurement and capture management 有权
    LV阈值测量和捕获管理

    公开(公告)号：US08744579B2

    公开(公告)日：2014-06-03

    申请号：US12700454

    申请日：2010-02-04

    申请人： Purvee P. Parikh ,  John C. Stroebel ,  Todd J. Sheldon ,  Karen J. Kleckner

    发明人： Purvee P. Parikh ,  John C. Stroebel ,  Todd J. Sheldon ,  Karen J. Kleckner

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/371

    摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).

    摘要翻译： 本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。 例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保 阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。 所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。