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公开(公告)号：US20100210645A1
公开(公告)日：2010-08-19
申请号：US12765820
申请日：2010-04-22
申请人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, JR.
发明人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, JR.
IPC分类号： A61K31/5377 , A61K31/4985 , A61P19/00
CPC分类号： C07D487/04
摘要： Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
摘要翻译： 提供某些化学实体以及用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的使用方法， 以及用于治疗肥胖，肌肉减少症，消瘦综合征，虚弱，恶病质，肌肉痉挛，手术后和创伤后肌肉无力，神经肌肉疾病等症状的治疗方法。
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公开(公告)号：US08293761B2
公开(公告)日：2012-10-23
申请号：US12765820
申请日：2010-04-22
申请人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： A61K31/44
CPC分类号： C07D487/04
摘要： Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
摘要翻译： 提供某些化学实体以及用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的使用方法， 以及用于治疗肥胖，肌肉减少症，消瘦综合征，虚弱，恶病质，肌肉痉挛，手术后和创伤后肌肉无力，神经肌肉疾病等症状的治疗方法。
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![Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use](/abs-image/US/2009/10/06/US07598248B2/abs.jpg.150x150.jpg)
3.发明授权Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use 有权某些1H-咪唑并[4,5-b]吡嗪-2（3H） - 酮和1H-咪唑并[4,5-b]吡嗪-2-醇，其组合物及其使用方法公开(公告)号：US07598248B2
公开(公告)日：2009-10-06
申请号：US11888902
申请日：2007-08-01
申请人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： A61K31/497
CPC分类号： C07D487/04
摘要： Provided is at least one chemical entity chosen from compounds of Formula I and compounds of Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating of one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.
摘要翻译： 提供至少一种选自式I化合物和式II化合物的化学实体及其药学上可接受的盐，其组合物，及其用于调节骨髓肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌中的一种或多种的方法 肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T，骨骼肌和骨骼肌节。
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![Certain 1H-imidazo[4,5-B]pyrazin-2(3H)-ones and 1H-imidazo[4,5-B]pyrazin-2-ols, compositions thereof, and methods for their use](/abs-image/US/2011/06/07/US07956056B2/abs.jpg.150x150.jpg)
4.发明授权Certain 1H-imidazo[4,5-B]pyrazin-2(3H)-ones and 1H-imidazo[4,5-B]pyrazin-2-ols, compositions thereof, and methods for their use 有权某些1H-咪唑并[4,5-B]吡嗪-2（3H） - 酮和1H-咪唑并[4,5-B]吡嗪-2-醇及其使用方法公开(公告)号：US07956056B2
公开(公告)日：2011-06-07
申请号：US12573730
申请日：2009-10-05
申请人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： Provided is at least one chemical entity chosen from compounds of Formula I and Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.
摘要翻译： 提供了至少一种选自式I和式II化合物的化学实体及其药学上可接受的盐，其组合物，及其用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C中的一种或多种的方法， 骨骼肌肌钙蛋白I，骨骼肌钙蛋白T，骨骼肌和骨骼肌节。
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公开(公告)号：US20100093741A1
公开(公告)日：2010-04-15
申请号：US12573730
申请日：2009-10-05
申请人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, JR.
发明人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans, JR.
IPC分类号： A61K31/4985 , C07D487/04 , A61P3/04 , A61P3/00 , A61P21/00
CPC分类号： C07D487/04
摘要： Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
摘要翻译： 提供某些化学实体以及用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的使用方法， 以及用于治疗肥胖，肌肉减少症，消瘦综合征，虚弱，恶病质，肌肉痉挛，手术后和创伤后肌肉无力，神经肌肉疾病等症状的治疗方法。
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公开(公告)号：US20080146561A1
公开(公告)日：2008-06-19
申请号：US11888902
申请日：2007-08-01
申请人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans
发明人： Alex Muci , Jeffrey T. Finer , Pu-Ping Lu , Alan James Russell , Bradley P. Morgan , David J. Morgans
IPC分类号： A61K31/4985 , C07D471/04 , A61K31/5377 , A61P19/00 , A61P21/00 , C07D413/14
CPC分类号： C07D487/04
摘要： Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
摘要翻译： 提供某些化学实体以及用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的使用方法， 以及用于治疗肥胖，肌肉减少症，消瘦综合征，虚弱，恶病质，肌肉痉挛，手术后和创伤后肌肉无力，神经肌肉疾病等症状的治疗方法。
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公开(公告)号：US20100173930A1
公开(公告)日：2010-07-08
申请号：US12519518
申请日：2007-07-31
IPC分类号： A61K31/437 , C07D471/04 , A61P3/04 , A61P21/00
CPC分类号： C07D471/04
摘要： Provided are certain chemical entities, and methods of use to modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, neuromuscular disease, and other indications.
摘要翻译： 提供了某些化学实体和调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的用途的方法， 以及用于治疗肥胖，肌肉减少症，消瘦综合征，虚弱，肌肉痉挛，神经肌肉疾病和其他适应症的方法。
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公开(公告)号：US07919511B2
公开(公告)日：2011-04-05
申请号：US11888655
申请日：2007-07-31
申请人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： C07D421/02 , A61K31/44
CPC分类号： A61K31/44 , C07D213/82
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US20080146619A1
公开(公告)日：2008-06-19
申请号：US11888655
申请日：2007-07-31
申请人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
发明人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
IPC分类号： A61K31/44 , A61P21/00 , C07D421/02
CPC分类号： A61K31/44 , C07D213/82
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US07932270B2
公开(公告)日：2011-04-26
申请号：US11888625
申请日：2007-07-31
申请人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： C07D401/14 , A61K31/44
CPC分类号： C07D401/14 , C07D213/82 , C07D401/12 , C07D405/14
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体以及与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的化学实体，药物组合物和治疗方法。
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