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公开(公告)号：US11160456B2
公开(公告)日：2021-11-02
申请号：US13748498
申请日：2013-01-23
摘要： Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system that incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system generates tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system. The method comprises producing an image of an outline boundary of a volume of interest and generating spatially or temporally coregistered images based on speed of sound and/or ultrasonic attenuation and on absorbed optical energy within the outlined volume.
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公开(公告)号：US20220054017A1
公开(公告)日：2022-02-24
申请号：US17516138
申请日：2021-11-01
摘要： Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system that incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system generates tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system. The method comprises producing an image of an outline boundary of a volume of interest and generating spatially or temporally coregistered images based on speed of sound and/or ultrasonic attenuation and on absorbed optical energy within the outlined volume.
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3.发明申请Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use 审中-公开激光光声超声成像系统（LOUIS）及使用方法公开(公告)号：US20130190595A1
公开(公告)日：2013-07-25
申请号：US13748498
申请日：2013-01-23
IPC分类号： A61B5/00
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/4312 , A61B5/708 , A61B8/0825 , A61B8/4416 , A61B8/483 , A61B2562/14 , A61B2562/146 , A61B2576/00
摘要： Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system has means for generate tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system. The method comprises producing an image of an outline boundary of a volume of interest and generating spatially or temporally coregistered images based on speed of sound and/or ultrasonic attenuation and on absorbed optical energy within the outlined volume.
摘要翻译： 本文提供了用于三维断层摄影系统的系统，方法，组件。 该系统是采用激光超声波系统和激光光声系统的双模态成像系统。 双模态成像系统具有用于基于声速，超声衰减和/或超声后向散射来生成对象体内感兴趣体积的断层摄影图像的装置，并且用于产生在受试者中光吸收系数的分布的光声层析图像 基于吸收的光学能量密度或从其导出的各种定量参数。 还提供了一种用于增加使用双模态成像系统在受试者内获得的定量信息的对比度，分辨率和精度的方法。 该方法包括产生感兴趣体积的轮廓边界的图像，并且基于声速和/或超声波衰减以及轮廓体积内的吸收的光能产生空间或时间上的核心图像。
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4.发明申请Scanning Optoacoustic Imaging System with High Resolution and Improved Signal Collection Efficiency 审中-公开扫描光学成像系统具有高分辨率和改进的信号采集效率公开(公告)号：US20130190594A1
公开(公告)日：2013-07-25
申请号：US13748315
申请日：2013-01-23
CPC分类号： A61B5/0095 , A61B5/14542 , A61B5/14546 , A61B5/72 , A61B2562/14 , A61B2562/146
摘要： Provided herein are scanning, high-resolution optoacoustic imaging systems or microscopes. Generally, the system/microscope comprises subsystems for scanning a tissue or object therein with a wavelength of electromagnetic energy, such as optical energy, collecting and detecting ultrasonic waves produced when the tissue or object absorbs the incident wavelength and converting the same to an electrical signal, and for processing, analyzing and displaying the electrical signal as a digital image. Specifically, the system/microscope utilizes an off-axis parabolic reflector with a high numerical aperture value for deep tissue visualization. Also, provided is a method for collecting volumetric image data voxel-by-voxel within a subject utilizing the imaging system or microscope. A series of voxels within the scanned tissue produces detectable ultrasonic waves that are collected by the off-axis parabolic reflector and processed as described as a high-resolution image of the tissue or object therein.
摘要翻译： 这里提供扫描，高分辨率光声成像系统或显微镜。 通常，系统/显微镜包括用于扫描具有诸如光能的电磁能波长的组织或物体的子系统，当组织或物体吸收入射波长并将其转换为电信号时收集和检测产生的超声波 并且用于处理，分析和显示作为数字图像的电信号。 具体来说，系统/显微镜利用具有高数值孔径值的离轴抛物面反射器进行深层组织可视化。 此外，提供了一种利用成像系统或显微镜收集受试者内的体素图像数据体素的方法。 扫描的组织内的一系列体素产生可检测的超声波，其由离轴抛物面反射器收集，并如其中组织或物体的高分辨率图像所描述的那样被处理。
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