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14 条记录 (耗时 0.035 秒)

    METHOD FOR PRODUCING A COMPOSITE MADE OF OLIGONUCLEOTIDES OR POLYNUCLEOTIDES AND HYDROPHOBIC BIODEGRADABLE POLYMERS AS WELL AS COMPOSITE OBTAINED ACCORDING TO THE METHOD
    8.
    发明申请
    METHOD FOR PRODUCING A COMPOSITE MADE OF OLIGONUCLEOTIDES OR POLYNUCLEOTIDES AND HYDROPHOBIC BIODEGRADABLE POLYMERS AS WELL AS COMPOSITE OBTAINED ACCORDING TO THE METHOD 审中-公开
    用于生产寡核苷酸或多核苷酸的复合材料的方法以及根据该方法获得的复合材料的疏水性可生物降解聚合物

    公开(公告)号：US20080032946A1

    公开(公告)日：2008-02-07

    申请号：US11831627

    申请日：2007-07-31

    申请人： Alexander Borck ,  Tobias Diener

    发明人： Alexander Borck ,  Tobias Diener

    IPC分类号： C07H21/00 ,  A61K31/7088

    CPC分类号： A61L27/48 ,  A61L27/34 ,  A61L27/56 ,  C08L71/02 ,  C08L89/00

    摘要： A method for producing a composite made of oligonucleotides or polynucleotides and hydrophobic biodegradable polymers. The method comprises the following steps: (i) producing an aqueous solution of a polyethylene glycol having a mean molecular weight in the range from 600 to 8,000 g/mole; (ii) adding an aqueous, possibly buffered solution of oligonucleotides or polynucleotides to the aqueous solution from step (i); iii) freezing the aqueous solution from step (ii) and subsequently freeze-drying the frozen solution to obtain a freeze-dried substrate; (iv) providing a solution of the hydrophobic biodegradable polymer in an organic solvent; (v) adding the substrate obtained according to step (iii) to the solution of the polymer; and (vi) removing the organic solvent to obtain the composite. Also disclosed is a composite produced by the method.

    摘要翻译： 一种由寡核苷酸或多核苷酸和疏水性生物可降解聚合物制成的复合材料的制备方法。 该方法包括以下步骤：（i）制备平均分子量为600-8,000g / mol的聚乙二醇水溶液; （ii）向步骤（i）的水溶液中加入水性可能缓冲的寡核苷酸或多核苷酸溶液; iii）冷冻来自步骤（ii）的水溶液，随后冷冻干燥冷冻溶液以获得冷冻干燥的基材; （iv）提供疏水性可生物降解聚合物在有机溶剂中的溶液; （v）将根据步骤（iii）获得的底物加入到聚合物溶液中; 和（vi）除去有机溶剂得到复合物。 还公开了通过该方法制备的复合材料。

    Implant and method for manufacturing same
    9.
    发明授权
    Implant and method for manufacturing same 有权
    种植体及其制造方法

    公开(公告)号：US08974521B2

    公开(公告)日：2015-03-10

    申请号：US13369977

    申请日：2012-02-09

    申请人： Tobias Diener ,  Elisabeta Burean ,  Matthias Fringes

    发明人： Tobias Diener ,  Elisabeta Burean ,  Matthias Fringes

    IPC分类号： A61F2/06 ,  A61L33/00 ,  A61L31/16 ,  A61L31/18 ,  A61F2/915

    CPC分类号： A61L31/16 ,  A61F2/915 ,  A61F2250/0068 ,  A61L31/18 ,  A61L2300/606

    摘要： An implant having a preferably hollow cylindrical main structure comprising a large number of continuous openings and a coating which releases at least one pharmaceutically active substance. To attain a better distribution of the pharmaceutically active substance, at least 20% of the cross-sectional area, preferably at least 50% of the cross-sectional area, of at least a portion of the openings in a predetermined section of the main structure is covered with the coating which releases at least one pharmaceutically active substance. Furthermore, a system composed of a catheter and such an implant, a simple method for manufacturing such an implant or such a system is provided.

    摘要翻译： 具有优选中空圆柱形主结构的植入物，其包含大量连续开口和释放至少一种药物活性物质的涂层。 为了获得更好的药物活性物质的分布，在主结构的预定部分中的至少一部分开口的横截面面积的至少20％，优选至少50％的横截面面积 被涂层释放至少一种药物活性物质。 此外，提供了由导管和这种植入物组成的系统，制造这种植入物或这种系统的简单方法。

    CATHETER, SYSTEM FOR APPLYING AN INTRALUMINAL ENDOPROSTHESIS AND METHOD FOR PRODUCING SAME
    10.
    发明申请
    CATHETER, SYSTEM FOR APPLYING AN INTRALUMINAL ENDOPROSTHESIS AND METHOD FOR PRODUCING SAME 审中-公开
    导管，用于应用内源性内切酶的系统及其生产方法

    公开(公告)号：US20120109276A1

    公开(公告)日：2012-05-03

    申请号：US13277694

    申请日：2011-10-20

    申请人： Tobias Diener ,  Elisabeta Burean ,  Matthias Fringes

    发明人： Tobias Diener ,  Elisabeta Burean ,  Matthias Fringes

    IPC分类号： A61F2/84 ,  B23P11/00 ,  A61M29/00

    CPC分类号： A61M25/1027 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1086 ,  Y10T29/49826

    摘要： The present invention relates to a catheter comprising a balloon (10, 30) and at least one pharmaceutically active substance. To enable more accurate dosing of the pharmaceutically active substance, the pharmaceutically active substance is disposed in a reservoir (15, 35) inside the balloon (10, 30) or on the balloon (10, 30), wherein a wall (14, 32, 34) that closes the reservoir toward the outside comprises at least one predetermined breaking point (16). Furthermore, a system for applying an intraluminal endoprosthesis, preferably a stent, in a body cavity, and simple and cost-effective methods for manufacturing the catheter and the system are described.

    摘要翻译： 本发明涉及包含球囊（10,30）和至少一种药物活性物质的导管。 为了能够更准确地计量药物活性物质，药物活性物质被设置在球囊（10,30）内或球囊（10,30）上的储存器（15,35）中，其中壁（14,32） ，34），其将储存器封闭到外部包括至少一个预定的断点（16）。 此外，描述了一种用于在体腔中施用管腔内假体，优选支架的系统，以及用于制造导管和系统的简单且成本有效的方法。