公开(公告)号：US07061237B2

公开(公告)日：2006-06-13

申请号：US10268922

申请日：2002-10-09

申请人： Alexander Pines ,  Sunil Saxena ,  Adam Moule ,  Megan Spence ,  Juliette A. Seeley ,  Kimberly L. Pierce ,  Song-I Han ,  Josef Granwehr

发明人： Alexander Pines ,  Sunil Saxena ,  Adam Moule ,  Megan Spence ,  Juliette A. Seeley ,  Kimberly L. Pierce ,  Song-I Han ,  Josef Granwehr

IPC分类号： G01V3/00

CPC分类号： G01R33/282 ,  A61K49/1815 ,  G01R33/46 ,  G01R33/5601

摘要： An apparatus and method for remote NMR/MRI spectroscopy having an encoding coil with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps. This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb—Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.