公开(公告)号：US20100091274A1

公开(公告)日：2010-04-15

申请号：US12287549

申请日：2008-10-10

申请人： Alexandre M. Bratkovski ,  Ekaterina Viktorovna Ponizovskaya ,  Zhiyong Li

发明人： Alexandre M. Bratkovski ,  Ekaterina Viktorovna Ponizovskaya ,  Zhiyong Li

IPC分类号： G01J3/44 ,  G01N21/55

CPC分类号： G01N21/658

摘要： Various embodiments of the present invention relate to plasmonic electric-field concentrators and to systems incorporating the plasmonic electric-field concentrators to perform Raman spectroscopy. In one aspect, a plasmonic electric-field concentrator comprises two or more large features, and a relatively small feature similar in shape to large features positioned adjacent to the two or more large features. The features are arranged so that when light of an appropriate wavelength is incident on the features, surface plasmon polaritons form on the outer surfaces of the features. The surface plasmon polaritons have associated electric fields extending perpendicular to the surfaces of the features. The electric fields are concentrated in the space between features forming an electric field hot spot that enhances Raman scattered light emitted from an analyte proximate to or absorbed on the features.

摘要翻译： 本发明的各种实施例涉及等离子体电场集中器以及结合等离子体激元集中器以执行拉曼光谱的系统。 一方面，等离子体电场集中器包括两个或更多个大特征，以及与形状相邻的相对较小的特征，其尺寸与两个或更多个特征邻近的大特征相似。 特征被布置成使得当适当波长的光入射到特征上时，在特征的外表面上形成表面等离子体激元。 表面等离子体激元极化子具有垂直于特征表面延伸的相关电场。 电场集中在形成电场热点的特征之间的空间中，其增强了从附近或被吸收在特征上的分析物发射的拉曼散射光。

公开(公告)号：US07995201B2

公开(公告)日：2011-08-09

申请号：US12287549

申请日：2008-10-10

申请人： Alexandre M. Bratkovski ,  Ekaterina Viktorovna Ponizovskaya ,  Zhiyong Li

发明人： Alexandre M. Bratkovski ,  Ekaterina Viktorovna Ponizovskaya ,  Zhiyong Li

IPC分类号： G01J3/44

CPC分类号： G01N21/658

摘要： Various embodiments of the present invention relate to plasmonic electric-field concentrators and to systems incorporating the plasmonic electric-field concentrators to perform Raman spectroscopy. In one aspect, a plasmonic electric-field concentrator comprises two or more large features, and a relatively small feature similar in shape to large features positioned adjacent to the two or more large features. The features are arranged so that when light of an appropriate wavelength is incident on the features, surface plasmon polaritons form on the outer surfaces of the features. The surface plasmon polaritons have associated electric fields extending perpendicular to the surfaces of the features. The electric fields are concentrated in the space between features forming an electric field hot spot that enhances Raman scattered light emitted from an analyte proximate to or absorbed on the features.

摘要翻译： 本发明的各种实施例涉及等离子体电场集中器以及结合等离子体激元集中器以执行拉曼光谱的系统。 一方面，等离子体电场集中器包括两个或更多个大特征，以及与形状相邻的相对较小的特征，其尺寸与两个或更多个特征邻近的大特征相似。 特征被布置成使得当适当波长的光入射到特征上时，在特征的外表面上形成表面等离子体激元。 表面等离子体激元极化子具有垂直于特征表面延伸的相关电场。 电场集中在形成电场热点的特征之间的空间中，其增强了从附近或被吸收在特征上的分析物发射的拉曼散射光。

公开(公告)号：US09453793B2

公开(公告)日：2016-09-27

申请号：US13452218

申请日：2012-04-20

申请人： Alexandre M Bratkovski ,  R Stanley Williams ,  Zhiyong Li

发明人： Alexandre M Bratkovski ,  R Stanley Williams ,  Zhiyong Li

IPC分类号： G01N21/00 ,  G01N21/01 ,  G01N21/65 ,  G01N21/64

CPC分类号： G01N21/01 ,  G01N21/648 ,  G01N21/658

摘要： Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a flexible substrate, and an array of spaced apart sensing members formed on a surface of the flexible substrate. Each of the spaced apart sensing members includes a plurality of polygon assemblies. The polygon assemblies are arranged in a controlled pattern on the surface of the flexible substrate such that each of the plurality of polygon assemblies is a predetermined distance from each other of the plurality of polygon assemblies, and each of the plurality of polygon assemblies including collapsible signal amplifying structures controllably positioned in a predetermined geometric shape.

摘要翻译： 本文公开了集成传感器的示例。 集成传感器的示例包括柔性基板和形成在柔性基板的表面上的间隔开的感测部件阵列。 每个间隔开的感测构件包括多个多边形组件。 多边形组件以可控的图案布置在柔性基板的表面上，使得多个多边形组件中的每一个距离多个多边形组件中的彼此之间是预定距离，并且多个多边形组件中的每一个包括可折叠信号 放大结构可控地定位在预定的几何形状。

公开(公告)号：US20150116706A1

公开(公告)日：2015-04-30

申请号：US14394287

申请日：2012-04-24

申请人： Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

发明人： Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

IPC分类号： G01N21/65

CPC分类号： G01N21/658 ,  B82Y15/00 ,  G01N2201/06113 ,  Y10S977/954

摘要： An apparatus for performing a sensing application includes a reservoir to contain a solution, a dispenser to dispense the solution from the reservoir, and a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, in which the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other. The apparatus also includes an illumination source to illuminate the received solution, an analyte introduced around the plurality of nano-fingers, and the plurality of nano-fingers, in which light is to be emitted from the analyte in response to being illuminated. The apparatus further includes a detector to detect the light emitted from the analyte.

摘要翻译： 用于执行感测应用的装置包括容纳溶液的储存器，用于从储存器分配溶液的分配器以及具有多个纳米手指的基板，该多个纳米手指定位成接收分配的溶液，其中多个纳米手指 是柔性的，使得多个纳米手指可相对于彼此配置。 所述装置还包括照亮所接收的溶液的照明源，围绕所述多个纳米手指引入的分析物和所述多个纳米手指，其中光将响应于被照亮从分析物发射。 该装置还包括检测器，用于检测从分析物发射的光。

公开(公告)号：US20140036262A1

公开(公告)日：2014-02-06

申请号：US13562567

申请日：2012-07-31

申请人： Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  R Stanley Williams

发明人： Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  R Stanley Williams

IPC分类号： G01J3/44

CPC分类号： G01N21/658

摘要： An apparatus for surface enhanced Raman spectroscopy includes a substrate, a nanostructure and a plasmonic material. The nanostructure and the plasmonic material are integrated together to provide electronic and plasmonic enhancement to a Raman signal produced by electromagnetic radiation scattering from an analyte.

摘要翻译： 用于表面增强拉曼光谱的装置包括底物，纳米结构和等离子体激元材料。 将纳米结构和等离子体激元材料集成在一起，以对由分析物的电磁辐射散射产生的拉曼信号提供电子和等离子体增强。

公开(公告)号：US20140029002A1

公开(公告)日：2014-01-30

申请号：US13561561

申请日：2012-07-30

申请人： Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

发明人： Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  B82Y15/00

摘要： A sensor for surface enhanced Raman spectroscopy (SERS) sensor includes surfaces and an actuator to adjust an intersurface spacing between the surfaces to contain an analyte and allow the analyte to be released from containment.

摘要翻译： 用于表面增强拉曼光谱（SERS）传感器的传感器包括表面和致动器，以调节表面之间的表面间隔，以包含分析物并允许分析物从容纳物释放。

公开(公告)号：US08559003B2

公开(公告)日：2013-10-15

申请号：US13384456

申请日：2009-09-17

申请人： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

发明人： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  B82Y15/00 ,  B82Y30/00

摘要： An electrically driven device for surface enhanced Raman spectroscopy includes a first electrode, a substrate positioned proximate to the first electrode, a plurality of cone shaped protrusions formed integrally with or on a substrate surface, a Raman signal-enhancing material coated on each protrusion, and a second electrode positioned relative to the first electrode at a predetermined distance. Each of the protrusions has a tip with a radius of curvature ranging from about 0.1 nm to about 100 nm. The second electrode is positioned relative to the first electrode such that the electrodes together produce an electric field when a voltage bias is applied therebetween. The electric field has a field distribution that creates a stronger field gradient at a region proximate to the tips than at other portions of the substrate.

摘要翻译： 用于表面增强拉曼光谱的电驱动装置包括第一电极，靠近第一电极定位的基板，与基底表面一体地形成的多个锥形突起，涂覆在每个突起上的拉曼信号增强材料，以及 相对于第一电极以预定距离定位的第二电极。 每个突起具有具有约0.1nm至约100nm范围的曲率半径的尖端。 第二电极相对于第一电极定位，使得当在其之间施加电压偏置时，电极一起产生电场。 电场具有场分布，其在靠近尖端的区域处产生比在衬底的其它部分更强的场梯度。

公开(公告)号：US20120200851A1

公开(公告)日：2012-08-09

申请号：US13384866

申请日：2009-10-23

申请人： Wei Wu ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan (SY) Wang ,  Alexandre M. Bratkovski

发明人： Wei Wu ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan (SY) Wang ,  Alexandre M. Bratkovski

IPC分类号： G01J3/44

CPC分类号： G01N21/658

摘要： A light amplifying structure 100 for Raman spectroscopy includes a a resonant cavity 108. A distance between a first portion 102B and a second portion 102A of the structure 100 forming the resonant cavity 108 is used to amplify excitation light emitted from a light source 420 into the resonant cavity 108 at a first resonant frequency of the resonant cavity 108. Also, the resonant cavity 108 amplifies radiated light radiated from a predetermined molecule excited by the excitation light in the resonant cavity at a second resonant frequency of the resonant cavity 108.

摘要翻译： 用于拉曼光谱的光放大结构100包括谐振腔108.第一部分102B和形成谐振腔108的结构100的第二部分102A之间的距离用于将从光源420发射的激发光放大到谐振腔 谐振腔108在谐振腔108的第二谐振频率处放大从由谐振腔中的激发光激发的预定分子辐射的辐射光。

公开(公告)号：US08208137B2

公开(公告)日：2012-06-26

申请号：US12696853

申请日：2010-01-29

申请人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

发明人： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G01J3/44

摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.

摘要翻译： 用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源， 以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光 以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

公开(公告)号：US20110188034A1

公开(公告)日：2011-08-04

申请号：US12697136

申请日：2010-01-29

申请人： Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

发明人： Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01N21/658

摘要： A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.

摘要翻译： 表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。 该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。 尖端被配置为吸附分析物并以振动频率振动。 该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。 纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。 该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。 该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。