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公开(公告)号：US08084467B2
公开(公告)日：2011-12-27
申请号：US11166835
申请日：2005-06-24
IPC分类号： A61K31/4453 , A61K31/44 , A61K31/41 , A61K31/415 , A61K31/381 , C07D401/12 , C07D257/04 , C07D231/12 , C07D409/10
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D401/10 , C07D401/14 , C07D403/10 , C07D409/10
摘要： One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
摘要翻译： 本发明的一个方面涉及大麻仿制吡唑类似物。 本发明的另一方面涉及对CB1大麻素受体具有高亲和力和/或选择性的新的和改进的吡唑类似物。 本发明的另一方面涉及采用本发明类似物的药物制剂和施用治疗有效量的本发明类似物以提供生理作用的方法。
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公开(公告)号：US08853205B2
公开(公告)日：2014-10-07
申请号：US13202499
申请日：2009-02-19
IPC分类号： C07D231/14 , C07D233/90 , C07D409/04 , C07D405/12 , C07D401/10
CPC分类号： C07D231/14 , C07D233/90 , C07D401/10 , C07D405/12 , C07D409/04
摘要： Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1 or CB2 receptor, acting as neutral antagonists, acting preferentially on CB 1 receptors located in the peripheral nervous system, and/or acting as nitric oxide donors. Pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect are also disclosed.
摘要翻译： 公开了能够与CB1和/或CB2大麻素受体相互作用的生物活性杂吡咯类似物，例如咪唑，噻唑，恶唑和吡唑。 方面公开了作为CB1和/或CB1受体拮抗剂的杂吡咯类似物，对CB 1或CB 2受体具有选择性，作为中性拮抗剂，优先作用于位于周围神经系统的CB 1受体，和/或作为硝酸 氧化物供体。 还公开了使用公开的类似物的药物制剂和施用治疗有效量的所公开的类似物以提供生理作用的方法。
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公开(公告)号：US20170001980A9
公开(公告)日：2017-01-05
申请号：US14507501
申请日：2014-10-06
IPC分类号： C07D401/12 , C07D231/14
CPC分类号： C07D401/12 , C07D231/14
摘要： Biologically active cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools or biomarkers. Pharmaceutical compositions may include one or more of the nitrate ester compounds. Medicaments include one or more of the cannabinergic nitrate ester compounds and are useful in treating a variety of diseases. A method of treating, preventing or reducing the severity of a condition includes administering at least one of the disclosed nitrate ester compounds to an individual or animal in need thereof.
摘要翻译： 生物活性大麻素能硝酸酯和相关类似物，制备方法，药物组合物及其作为药物使用的方法，药理学工具或生物标志物。 药物组合物可包括一种或多种硝酸酯化合物。 药物包括一种或多种大麻素能硝酸酯化合物，并且可用于治疗各种疾病。 治疗，预防或降低病症严重程度的方法包括向所需的个体或动物施用至少一种所公开的硝酸酯化合物。
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公开(公告)号：US20160096822A1
公开(公告)日：2016-04-07
申请号：US14507501
申请日：2014-10-06
IPC分类号： C07D401/12 , C07D231/14
CPC分类号： C07D401/12 , C07D231/14
摘要： Biologically active cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools or biomarkers. Pharmaceutical compositions may include one or more of the nitrate ester compounds. Medicaments include one or more of the cannabinergic nitrate ester compounds and are useful in treating a variety of diseases. A method of treating, preventing or reducing the severity of a condition includes administering at least one of the disclosed nitrate ester compounds to an individual or animal in need thereof.
摘要翻译： 生物活性大麻素能硝酸酯和相关类似物，制备方法，药物组合物及其作为药物使用的方法，药理学工具或生物标志物。 药物组合物可包括一种或多种硝酸酯化合物。 药物包括一种或多种大麻素能硝酸酯化合物，并且可用于治疗各种疾病。 治疗，预防或降低病症严重程度的方法包括向所需的个体或动物施用至少一种所公开的硝酸酯化合物。
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