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10 条记录 (耗时 0.026 秒)

    Pyrazole analogs acting on cannabinoid receptors
    2.
    发明授权
    Pyrazole analogs acting on cannabinoid receptors 有权
    吡唑类似物作用于大麻素受体

    公开(公告)号：US07745440B2

    公开(公告)日：2010-06-29

    申请号：US11244770

    申请日：2005-10-06

    申请人： Alexandros Makriyannis ,  Qian Liu ,  Rajesh Thotapally

    发明人： Alexandros Makriyannis ,  Qian Liu ,  Rajesh Thotapally

    IPC分类号： A61K31/53 ,  A61K31/506 ,  A61K31/4709 ,  A61K31/4439 ,  C07D413/02

    CPC分类号： C07D401/00 ,  C07D231/14 ,  C07D401/10 ,  C07D403/10

    摘要： One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.

    摘要翻译： 本发明的一个方面涉及大麻仿制吡唑类似物。 本发明的另一方面涉及对CB1大麻素受体具有高亲和力和/或选择性的新的和改进的吡唑类似物。 本发明的另一方面涉及采用本发明类似物的药物制剂和施用治疗有效量的本发明类似物以提供生理作用的方法。

    Heteropyrrole analogs acting on cannabinoid receptors
    6.
    发明授权
    Heteropyrrole analogs acting on cannabinoid receptors 有权
    作用于大麻素受体的异丙吡咯类似物

    公开(公告)号：US08410097B2

    公开(公告)日：2013-04-02

    申请号：US13334163

    申请日：2011-12-22

    申请人： Alexandros Makriyannis ,  Rajesh Thotapally ,  Venkata Kiran Rao Vemuri ,  Teresa Olszewska

    发明人： Alexandros Makriyannis ,  Rajesh Thotapally ,  Venkata Kiran Rao Vemuri ,  Teresa Olszewska

    IPC分类号： A61K31/41 ,  A61K31/405 ,  C07D207/00 ,  C07D209/00

    CPC分类号： C07D233/90 ,  C07D401/10 ,  C07D403/10 ,  C07D417/10

    摘要： Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect discloses hetero pyrrole analogs acting as antagonists for the CB1 and/or the CB2 receptors. Another aspect discloses hetero pyrrole analogs having selectivity for the CB1 or CB2 cannabinoid receptor. Also disclosed are pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect.

    摘要翻译： 公开了能够与CB1和/或CB2大麻素受体相互作用的生物活性杂吡咯类似物，例如咪唑，噻唑，恶唑和吡唑。 一方面公开了作为CB1和/或CB2受体拮抗剂的杂吡咯类似物。 另一方面公开了对CB1或CB2大麻素受体具有选择性的异构吡咯类似物。 还公开了采用公开的类似物的药物制剂和施用治疗有效量的所公开的类似物以提供生理作用的方法。