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    Systems and methods for topical treatment with nitric oxide
    4.
    发明授权
    Systems and methods for topical treatment with nitric oxide 失效
    用一氧化氮局部治疗的系统和方法

    公开(公告)号：US6103275A

    公开(公告)日：2000-08-15

    申请号：US95174

    申请日：1998-06-10

    申请人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    发明人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    IPC分类号： A61K9/00 ,  A61K33/00 ,  A61K47/12

    CPC分类号： A61K33/00 ,  A61K47/12 ,  A61K9/0014

    摘要： A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, vaseline) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns, intra-cavity, etc.). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.

    摘要翻译： 描述了用于产生一氧化氮（NO）的简单的生物相容性系统和程序。 粉状亚硝酸钠，抗坏血酸和马来酸（或具有足够强度的另一种有机酸）的混合物在用水处理时立即产生一氧化氮（NO）。 为了减缓NO代，可以从非水介质（凡士林，凡士林）和三种粉末成分制备软膏，当皮肤上局部施用时，水会透过该介质释放NO; 或者，可以用羟乙基纤维素（或其他凝胶形成化合物）将亚硝酸钠水溶液转化成凝胶，并将该凝胶与由抗坏血酸和马来酸水溶液获得的羟乙基纤维素获得的另一种凝胶组合，用于局部施用（在完整的皮肤，烧伤，内部 - 腔等）。 两种凝胶可以在使用之前立即混合（可能来自具有分开的腔室和双喷嘴的单个容器，通过将两个凝胶通过喷嘴挤压或挤压），或者可以以夹心状的方式施用（可能为透皮贴剂） 进一步减缓NO的运送。

    Systems and methods for topical treatment with nitric oxide
    5.
    发明授权
    Systems and methods for topical treatment with nitric oxide 有权
    用一氧化氮局部治疗的系统和方法

    公开(公告)号：US07048951B1

    公开(公告)日：2006-05-23

    申请号：US10296110

    申请日：2000-05-24

    申请人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    发明人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    IPC分类号： A61K33/00

    CPC分类号： A61K33/00 ,  A61K9/0014 ,  A61K47/12

    摘要： A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, Vaseline™) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns intra-cavity, burns, intra-cavity, etc.). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.

    摘要翻译： 描述了用于产生一氧化氮（NO）的简单的生物相容性系统和程序。 粉状亚硝酸钠，抗坏血酸和马来酸（或具有足够强度的另一种有机酸）的混合物在用水处理时立即产生一氧化氮（NO）。 为了减缓NO代，可以从非水介质（凡士林，凡士林（Vaseline TM））和三种粉末成分制备软膏，当皮肤上局部施用时，水会透过该介质释放NO; 或者，可以用羟乙基纤维素（或其他凝胶形成化合物）将亚硝酸钠水溶液转化成凝胶，并将该凝胶与由抗坏血酸和马来酸水溶液获得的羟乙基纤维素的另一凝胶结合，用于局部施用（在完整的皮肤上， 腔，烧伤，腔内等）。 两种凝胶可以在使用之前立即混合（可能来自具有分开的腔室和双喷嘴的单个容器，通过将两个凝胶通过喷嘴挤压或挤压），或者可以以夹心状的方式施用（可能为透皮贴剂） 进一步减缓NO的运送。