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    Systems and methods for topical treatment with nitric oxide
    3.
    发明授权
    Systems and methods for topical treatment with nitric oxide 有权
    用一氧化氮局部治疗的系统和方法

    公开(公告)号：US07048951B1

    公开(公告)日：2006-05-23

    申请号：US10296110

    申请日：2000-05-24

    申请人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    发明人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    IPC分类号： A61K33/00

    CPC分类号： A61K33/00 ,  A61K9/0014 ,  A61K47/12

    摘要： A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, Vaseline™) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns intra-cavity, burns, intra-cavity, etc.). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.

    摘要翻译： 描述了用于产生一氧化氮（NO）的简单的生物相容性系统和程序。 粉状亚硝酸钠，抗坏血酸和马来酸（或具有足够强度的另一种有机酸）的混合物在用水处理时立即产生一氧化氮（NO）。 为了减缓NO代，可以从非水介质（凡士林，凡士林（Vaseline TM））和三种粉末成分制备软膏，当皮肤上局部施用时，水会透过该介质释放NO; 或者，可以用羟乙基纤维素（或其他凝胶形成化合物）将亚硝酸钠水溶液转化成凝胶，并将该凝胶与由抗坏血酸和马来酸水溶液获得的羟乙基纤维素的另一凝胶结合，用于局部施用（在完整的皮肤上， 腔，烧伤，腔内等）。 两种凝胶可以在使用之前立即混合（可能来自具有分开的腔室和双喷嘴的单个容器，通过将两个凝胶通过喷嘴挤压或挤压），或者可以以夹心状的方式施用（可能为透皮贴剂） 进一步减缓NO的运送。

    Systems and methods for topical treatment with nitric oxide
    4.
    发明授权
    Systems and methods for topical treatment with nitric oxide 失效
    用一氧化氮局部治疗的系统和方法

    公开(公告)号：US6103275A

    公开(公告)日：2000-08-15

    申请号：US95174

    申请日：1998-06-10

    申请人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    发明人： William A. Seitz ,  Robert E. Garfield ,  Alexandru T. Balaban ,  Randall J. Stewart

    IPC分类号： A61K9/00 ,  A61K33/00 ,  A61K47/12

    CPC分类号： A61K33/00 ,  A61K47/12 ,  A61K9/0014

    摘要： A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, vaseline) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns, intra-cavity, etc.). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.

    摘要翻译： 描述了用于产生一氧化氮（NO）的简单的生物相容性系统和程序。 粉状亚硝酸钠，抗坏血酸和马来酸（或具有足够强度的另一种有机酸）的混合物在用水处理时立即产生一氧化氮（NO）。 为了减缓NO代，可以从非水介质（凡士林，凡士林）和三种粉末成分制备软膏，当皮肤上局部施用时，水会透过该介质释放NO; 或者，可以用羟乙基纤维素（或其他凝胶形成化合物）将亚硝酸钠水溶液转化成凝胶，并将该凝胶与由抗坏血酸和马来酸水溶液获得的羟乙基纤维素获得的另一种凝胶组合，用于局部施用（在完整的皮肤，烧伤，内部 - 腔等）。 两种凝胶可以在使用之前立即混合（可能来自具有分开的腔室和双喷嘴的单个容器，通过将两个凝胶通过喷嘴挤压或挤压），或者可以以夹心状的方式施用（可能为透皮贴剂） 进一步减缓NO的运送。

    Method and apparatus for analyzing uterine electrical activity from surface measurements for obstetrical diagnosis
    8.
    发明授权
    Method and apparatus for analyzing uterine electrical activity from surface measurements for obstetrical diagnosis 失效
    用于从产科诊断的表面测量中分析子宫电活动的方法和装置

    公开(公告)号：US5623939A

    公开(公告)日：1997-04-29

    申请号：US483755

    申请日：1995-06-07

    申请人： Robert E. Garfield

    发明人： Robert E. Garfield

    IPC分类号： A61B5/03 ,  A61B5/0408 ,  A61B5/0488 ,  A61B10/00 ,  A61B5/04

    CPC分类号： A61B5/04882 ,  A61B5/4356 ,  A61B5/035 ,  A61B5/04085 ,  A61B5/42 ,  A61B5/7203 ,  A61B5/7242 ,  A61B5/726

    摘要： A method and apparatus is presented for recording uterine electrical activity from the surface of the abdomen or vagina for the purpose of diagnosing contractile patterns of the uterus in pregnant and nonpregnant patients. The present invention provides data analysis techniques for analyzing electromyographic data measured from the surface of a patient to characterize uterine activity. The method and apparatus described include algorithms for the systematic analysis of electrical signals recorded from the abdominal surface. Such processing comprises integration of signals, frequency spectral analysis, 3-dimensional power density mesh plots, vector analysis, fast wavelet transform, and joint time-frequency characteristics. These techniques and apparatus are appropriate for use in a clinic or through communication lines for use as a remote or home uterine monitoring system. As such, uterine electrical activity may be measured at a remote location and processed at a central facility through on-line communications channels, such as a telephone line. The techniques and apparatus disclosed are also useful in predicting successful treatment for cases where either the uterus fails to develop forceful contractions at term or begins to contract pre-term.

    摘要翻译： 提出了一种从腹部或阴道表面记录子宫电活动的方法和装置，目的是诊断怀孕和非妊娠患者子宫的收缩模式。 本发明提供了用于分析从患者表面测量的肌电图数据以表征子宫活动的数据分析技术。 所描述的方法和装置包括用于系统分析从腹部表面记录的电信号的算法。 这种处理包括信号的集成，频谱分析，三维功率密度网格图，向量分析，快速小波变换和联合时频特征。 这些技术和装置适用于诊所或通过通信线路用于远程或家庭子宫监测系统。 因此，可以在远程位置测量子宫电活动，并通过诸如电话线的在线通信信道在中央设施处理子宫电活动。 所公开的技术和设备也可用于预测成功治疗子宫未发展有力收缩或开始于术前合并的情况。

    UTERINE ELECTRICAL STIMULATION SYSTEM AND METHOD
    9.
    发明申请
    UTERINE ELECTRICAL STIMULATION SYSTEM AND METHOD 有权
    子宫电刺激系统及方法

    公开(公告)号：US20130261702A1

    公开(公告)日：2013-10-03

    申请号：US13881812

    申请日：2011-10-26

    申请人： Robert E. Garfield ,  Harvey Carp ,  William L. Maner

    发明人： Robert E. Garfield ,  Harvey Carp ,  William L. Maner

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0521 ,  A61M25/10 ,  A61M2025/105 ,  A61N1/0476 ,  A61N1/05 ,  A61N1/0524 ,  A61N1/36007

    摘要： Systems and methods for applying stimulating current to a patient for treating insufficient uterine contractions are provided. The system includes stimulation electrodes of a balloon electrode array device, a ring electrode array device, an electrode probe device, or a mesh electrode array device. Some aspects of the invention also provide a connector and cable device for coupling the stimulation electrodes to electronics for generating and providing the stimulating current to the stimulation electrodes.

    摘要翻译： 提供了将刺激电流施加到患者以治疗不充分的子宫收缩的系统和方法。 该系统包括气球电极阵列器件的刺激电极，环形电极阵列器件，电极探针器件或网状电极阵列器件。 本发明的一些方面还提供了用于将刺激电极耦合到电子器件的连接器和电缆装置，用于产生刺激电流并向刺激电极提供刺激电流。

    CERVICAL, FETAL-MEMBRANE, AND AMNIOTIC EXAMINATION AND ASSESSMENT DEVICE AND METHOD
    10.
    发明申请
    CERVICAL, FETAL-MEMBRANE, AND AMNIOTIC EXAMINATION AND ASSESSMENT DEVICE AND METHOD 审中-公开
    宫颈癌，宫颈膜和生殖检查和评估装置及方法

    公开(公告)号：US20120249764A1

    公开(公告)日：2012-10-04

    申请号：US13389175

    申请日：2010-08-09

    申请人： Ruben Kuon ,  William L. Maner ,  Robert E. Garfield ,  Richard Blumrick

    发明人： Ruben Kuon ,  William L. Maner ,  Robert E. Garfield ,  Richard Blumrick

    IPC分类号： H04N7/18

    CPC分类号： A61B1/05 ,  A61B1/0607 ,  A61B1/0638 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/303

    摘要： Some embodiments of the invention provide a cervical, fetal-membrane, and amniotic examination and assessment device for use with a computer and a method for examining a cervix with the device. The device can include a probe with a camera and a reference laser system, a cable coupling the probe to the computer, and a device program executable by the computer. One method includes positioning a laser to illuminate a reference dot on a target area of the cervix, calculating a distance between the probe and the cervix using the reference laser system, capturing images of the target area at a desired distance using the camera, identifying features of the cervix, and measuring and quantifying boundaries of the features using the desired distance and an area of the reference dot in the images.

    摘要翻译： 本发明的一些实施方案提供了一种与计算机一起使用的子宫颈，胎膜和羊膜检查和评估装置以及用该装置检查子宫颈的方法。 该装置可以包括具有相机和参考激光系统的探头，将探头耦合到计算机的电缆以及可由计算机执行的装置程序。 一种方法包括定位激光以照亮子宫颈的目标区域上的参考点，使用参考激光系统计算探针和子宫颈之间的距离，使用相机捕获目标区域的图像在期望的距离，识别特征 的子宫颈，并且使用图像中的所需距离和参考点的面积来测量和量化特征的边界。