公开(公告)号：US20100056790A1

公开(公告)日：2010-03-04

申请号：US12621464

申请日：2009-11-18

申请人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Nadezhda Beznosko ,  Vladimir Sokolov

发明人： Alexey Aksinenko ,  Sergey Bachurin ,  Sergey Sablin ,  Bogdan Beznosko ,  Nadezhda Beznosko ,  Vladimir Sokolov

IPC分类号： C07D471/02

CPC分类号： C07D471/04

摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.

摘要翻译： 一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或 预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食 贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。 这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。 该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机​​制。