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公开(公告)号：US09828628B2
公开(公告)日：2017-11-28
申请号：US13988487
申请日：2011-11-21
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6818 , C12Q2525/301 , C12Q2565/1015 , C12Q2565/1025 , C12Q2545/113 , C12Q2563/131
摘要： Provided are unimolecular oligonucleotide probes for detecting a target in a sample. The probes use target binding-induced structural changes to detect the presence of the target in the sample. Also provided are methods of using the probes to detect a target in a sample.
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2.发明申请Nucleotide-Based Probes and Methods for the Detection and Quantification of Macromolecules and Other Analytes 有权基于核苷酸的探针和大分子和其他分析物的检测和定量方法公开(公告)号：US20130288923A1
公开(公告)日：2013-10-31
申请号：US13988487
申请日：2011-11-21
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6818 , C12Q2525/301 , C12Q2565/1015 , C12Q2565/1025 , C12Q2545/113 , C12Q2563/131
摘要： Provided are unimolecular oligonucleotide probes for detecting a target in a sample. The probes use target binding-induced structural changes to detect the presence of the target in the sample. Also provided are methods of using the probes to detect a target in a sample.
摘要翻译： 提供了用于检测样品中靶标的单分子寡核苷酸探针。 探针使用靶结合诱导的结构变化来检测样品中目标物的存在。 还提供了使用探针来检测样品中的靶的方法。
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3.发明授权Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use 有权螺 - 氨基 - 咪唑啉酮和螺 - 氨基 - 二氢 - 嘧啶酮化合物作为β-分泌酶调节剂和使用方法公开(公告)号：US08957083B2
公开(公告)日：2015-02-17
申请号：US13988745
申请日：2011-11-18
申请人： Ana Elena Minatti , Oleg Epstein , Ryan White , Matthew Weiss , Wenge Zhong , Jonathan D. Low
发明人： Ana Elena Minatti , Oleg Epstein , Ryan White , Matthew Weiss , Wenge Zhong , Jonathan D. Low
IPC分类号： C07D491/107 , C07D491/20
CPC分类号： C07D491/107 , C07D491/20
摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A4, A5, A6, A8, L, R2, R7, R9, W and Y of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, sub-Formula embodiments of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulae I-III.
摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式I：其中式I的变量A1，A3，A4，A5，A6，A8，L，R2，R7，R9，W和Y在本文中定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。 本发明还提供式II和III的化合物，式I，II和III的次级实施方案，可用于制备式I-III化合物的中间体和方法和方法。
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4.发明申请Spiro-Amino-Imidazo-Fused Heterocyclic Compounds as Beta-secretase Modulators and Methods of Use 有权螺氨基 - 咪唑并 - 杂环化合物作为β-分泌酶调节剂和使用方法公开(公告)号：US20140038954A1
公开(公告)日：2014-02-06
申请号：US13982096
申请日：2012-02-13
申请人： Oleg Epstein , Ryan White , Vinod F. Patel , Jason Human
发明人： Oleg Epstein , Ryan White , Vinod F. Patel , Jason Human
IPC分类号： C07D491/20
CPC分类号： C07D491/20 , A61K31/353
摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I, wherein variables A1, A3, A4, A5, A6, A8, R2, R7, X, Y and Z of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits and impairments, schizophrenia and other central nervous system conditions and disorders. The invention further provides compounds of Formulas II and III, and of sub-formulas of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.
摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式I，其中式I的变量A1，A3，A4，A5，A6，A8，R2，R7，X，Y和Z如本文所定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的病症包括例如阿尔茨海默病，认知缺陷和损伤，精神分裂症和其他中枢神经系统病症和障碍。 本发明还提供了式II和III的化合物和式I，II和III的分子式，可用于制备式I-III化合物的中间体和方法和方法。
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5.发明申请Spiro-Amino-Imidazolone and Spiro-Amino-Dihydro-Pyrimidinone Compounds as Beta-Secretase Modulators and Methods of Use 有权螺氨基 - 咪唑啉酮和螺 - 氨基 - 二氢 - 嘧啶酮化合物作为β-分泌酶调节剂和使用方法公开(公告)号：US20130338177A1
公开(公告)日：2013-12-19
申请号：US13988745
申请日：2011-11-18
申请人： Ana Elena Minatti , Oleg Epstein , Ryan White , Matthew Weiss , Wenge Zhong , Jonathan D. Low
发明人： Ana Elena Minatti , Oleg Epstein , Ryan White , Matthew Weiss , Wenge Zhong , Jonathan D. Low
IPC分类号： C07D491/107 , C07D491/20
CPC分类号： C07D491/107 , C07D491/20
摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I), wherein variables A1, A3, A4, A5, A6, A8, L, R2, R7, R9, W and Y of Formula (I) are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), sub-Formula embodiments of Formulas (I), (II) and (III), intermediates and processes and methods useful for the preparation of compounds of Formulae (I-III).
摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式（I），其中式（I）的变量A1，A3，A4，A5，A6，A8，L，R2，R7，R9，W和Y如本文所定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。 本发明还提供式（II）和（III）的化合物，式（I），（II）和（III）的分式实施方案，可用于制备式（I-III）化合物的中间体和方法和方法 ）。
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公开(公告)号：US08557816B2
公开(公告)日：2013-10-15
申请号：US13157195
申请日：2011-06-09
IPC分类号： A61K31/502
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D493/04 , C07D495/04
摘要： The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
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公开(公告)号：US07893061B2
公开(公告)日：2011-02-22
申请号：US11827910
申请日：2007-07-13
申请人： Ryan White
发明人： Ryan White
IPC分类号： C07D401/14 , A61K31/506
CPC分类号： C07D401/06 , C07D401/04 , C07D401/14 , C07D405/14
摘要： The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula I wherein A1-3, R1 and R3-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译： 本发明包括能够调节c-kit受体的新一类化合物，因此可用于治疗c-kit介导的疾病，包括各种炎性，纤维化和/或肥大细胞介导的疾病如肥大细胞增多症。 该化合物具有通式I，其中A1-3，R1和R3-6在本文中定义。 本发明还包括药物组合物，用于治疗c-kit介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号：US07700607B2
公开(公告)日：2010-04-20
申请号：US11879830
申请日：2007-07-18
申请人： Essa Hu , Jason Brooks Human , Roxanne Kunz , Andrew Tasker , Ryan White
发明人： Essa Hu , Jason Brooks Human , Roxanne Kunz , Andrew Tasker , Ryan White
IPC分类号： A61K31/517
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula I wherein R1-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译： 本发明包括能够调节c-kit受体的新一类化合物，因此可用于治疗c-kit介导的疾病，包括各种炎性，纤维化和/或肥大细胞介导的疾病如肥大细胞增多症。 化合物具有通式I，其中R1-6在本文中定义。 本发明还包括药物组合物，用于治疗c-kit介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号：US20090095034A1
公开(公告)日：2009-04-16
申请号：US11872394
申请日：2007-10-15
申请人： Ryan White , John Hung
发明人： Ryan White , John Hung
CPC分类号： E05B73/0005 , E05B37/0058 , E05B37/025 , E05B73/0082 , Y10T70/25 , Y10T70/40 , Y10T70/50 , Y10T70/5009 , Y10T70/554 , Y10T70/7305 , Y10T70/7316 , Y10T70/7418
摘要： A security apparatus, a security system that uses the security apparatus, and a method of using the securing apparatus to secure a portable electronic device to an immovable object. The security apparatus comprises a combination locking mechanism with dials and tumblers, a body coupled to the dials, a reset device coupled to the tumblers, and a reset key configured to interact with the reset device to allow the user to reset the combination associated with the combination locking mechanism.
摘要翻译： 一种安全装置，使用该安全装置的安全系统以及使用该固定装置将便携式电子装置固定在不可移动物体上的方法。 安全装置包括具有拨盘和翻转开关的组合锁定机构，耦合到拨盘的主体，耦合到翻转开关的复位装置以及配置成与复位装置相互作用的复位键，以允许用户重置与 组合锁定机构。
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公开(公告)号：USD496984S1
公开(公告)日：2004-10-05
申请号：US29180122
申请日：2003-04-18
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