公开(公告)号：US20050014208A1

公开(公告)日：2005-01-20

申请号：US10488828

申请日：2002-09-06

申请人： Alf-Andreas Krehan ,  Pia Steffens ,  Bertha Gutierrez ,  Stefanie Waschuetza

发明人： Alf-Andreas Krehan ,  Pia Steffens ,  Bertha Gutierrez ,  Stefanie Waschuetza

IPC分类号： C07K16/30 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574 ,  C12M1/34

CPC分类号： G01N33/54326 ,  C07K16/30 ,  G01N33/56966 ,  G01N33/57492

摘要： The present invention pertains to a procedure and a kit for the diagnosis or monitoring of breast cancer in humans. This procedure is based on the feature that one recognizes the presence or absence in a human blood sample of at least two different mRNAs that code for various members of the tumor marker proteins EGF-R, CEA, stanniocalcin, CK20, MAGE-3, GA733.2, MUC1, Her-2/neu, claudin-7, and/or PDGF-β, and a conclusion is drawn from this in regard to the presence of mammary carcinoma cells in the blood sample, and thus in regard to possible metastasis.

摘要翻译： 本发明涉及用于诊断或监测人类乳腺癌的方法和试剂盒。 该过程基于以下特征：人们认识到编码肿瘤标志物蛋白EGF-R，CEA，猕猴桃，CK20，MAGE-3，GA733的各种成员的至少两种不同mRNA的人血液样品中的存在或不存在 .2，MUC1，Her-2 / neu，claudin-7和/或PDGF-β，从血液样品中乳腺癌细胞的存在以及关于可能转移的结论 。