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18 条记录 (耗时 0.028 秒)

    Foam laminate transdermal patch
    1.
    发明授权
    Foam laminate transdermal patch 失效
    泡沫层压透皮贴片

    公开(公告)号：US5503844A

    公开(公告)日：1996-04-02

    申请号：US63515

    申请日：1993-05-18

    申请人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

    发明人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

    IPC分类号： A61K9/70 ,  A61F13/00 ,  A61F13/02

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.

    摘要翻译： 公开了将活性剂控制释放到主体的皮肤或粘膜上的装置，哪些装置是具有第一表面和第二表面的泡沫层的层压体，该泡沫层具有并入其中的活性剂; 背衬层，其具有内表面和外表面，其中内表面固定到泡沫层的第二表面，使得活性剂不能通过背衬层的外表面从泡沫层的第二表面渗透; 以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性剂能够从泡沫层的第一表面连续释放。 还公开了组装层压装置的方法，以及其中泡沫层由背衬层上的预聚物溶液形成的方法。 还公开了具有均匀分散在其中的活性剂的聚氨酯泡沫聚合的方法。

    Foam laminate transdermal patch
    2.
    发明授权
    Foam laminate transdermal patch 失效
    泡沫层压透皮贴片

    公开(公告)号：US5629014A

    公开(公告)日：1997-05-13

    申请号：US476418

    申请日：1995-06-07

    申请人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

    发明人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

    IPC分类号： A61K9/70 ,  A61F13/00

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.

    摘要翻译： 公开了将活性剂控制释放到主体的皮肤或粘膜上的装置，哪些装置是具有第一表面和第二表面的泡沫层的层压体，该泡沫层具有并入其中的活性剂; 背衬层，其具有内表面和外表面，其中内表面固定到泡沫层的第二表面，使得活性剂不能通过背衬层的外表面从泡沫层的第二表面渗透; 以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性剂能够从泡沫层的第一表面连续释放。 还公开了组装层压装置的方法，以及其中泡沫层由背衬层上的预聚物溶液形成的方法。 还公开了具有均匀分散在其中的活性剂的聚氨酯泡沫聚合的方法。