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公开(公告)号：US20050255553A1
公开(公告)日：2005-11-17
申请号：US11044051
申请日：2005-01-28
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US07785881B2
公开(公告)日：2010-08-31
申请号：US12011726
申请日：2008-01-29
IPC分类号： C12N15/86
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体以及包含肽，HLA分子，2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US20080311652A1
公开(公告)日：2008-12-18
申请号：US12011726
申请日：2008-01-29
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US07348007B2
公开(公告)日：2008-03-25
申请号：US11044051
申请日：2005-01-28
IPC分类号： A61K39/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/57
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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