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公开(公告)号：US09637542B2
公开(公告)日：2017-05-02
申请号：US14463689
申请日：2014-08-20
申请人： Alisa K. Waterman , Nick Mark Devoogdt , Tony Lahoutte , Matthias Schneider , Sanjaya Singh , Cedric Jozef Néotère Ververken
发明人： Alisa K. Waterman , Nick Mark Devoogdt , Tony Lahoutte , Matthias Schneider , Sanjaya Singh , Cedric Jozef Néotère Ververken
CPC分类号： C07K16/28 , A61K49/0058 , A61K49/04 , A61K49/221 , A61K51/10 , A61K51/1021 , A61K51/1093 , A61K2039/505 , A61P9/10 , C07K16/2866 , C07K2317/22 , C07K2317/569 , C07K2317/94 , G01N33/56966 , G01N33/6872 , G01N2333/7158
摘要： The present invention relates to CX3CR1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain CX3CR1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described. The CX3CR1-targeting imaging agents are useful in the treatment and diagnosis of CX3CR1-mediated diseases including atherosclerosis.
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2.发明申请CX3CR1-TARGETING IMAGING AGENTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF DISEASE 有权CX3CR1靶向成像剂及其在诊断和治疗疾病中的应用公开(公告)号：US20150056133A1
公开(公告)日：2015-02-26
申请号：US14463689
申请日：2014-08-20
申请人： Alisa K. WATERMAN , Nick Mark Devoogdt , Tony Lahoutte , Matthias SCHNEIDER , Sanjaya SINGH , Cedric Jozef Néotère VERVERKEN
发明人： Alisa K. WATERMAN , Nick Mark Devoogdt , Tony Lahoutte , Matthias SCHNEIDER , Sanjaya SINGH , Cedric Jozef Néotère VERVERKEN
CPC分类号： C07K16/28 , A61K49/0058 , A61K49/04 , A61K49/221 , A61K51/10 , A61K51/1021 , A61K51/1093 , A61K2039/505 , A61P9/10 , C07K16/2866 , C07K2317/22 , C07K2317/569 , C07K2317/94 , G01N33/56966 , G01N33/6872 , G01N2333/7158
摘要： The present invention relates to CX3CR1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain CX3CR1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described. The CX3CR1-targeting imaging agents are useful in the treatment and diagnosis of CX3CR1-mediated diseases including atherosclerosis.
摘要翻译： 本发明涉及CX3CR1靶向成像剂及其在疾病治疗和诊断中的应用。 描述了与检测标记物连接的单结构域CX3CR1靶向多肽及其在动脉粥样硬化斑块体内成像中的应用。 CX3CR1靶向成像剂可用于治疗和诊断CX3CR1介导的疾病，包括动脉粥样硬化。
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公开(公告)号：US20120301394A1
公开(公告)日：2012-11-29
申请号：US13480350
申请日：2012-05-24
申请人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
发明人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
IPC分类号： C07K16/28 , C12N9/96 , A61P35/00 , A61K49/00 , C12P21/00 , A61K51/00 , C07K17/00 , A61K39/395
CPC分类号： A61K51/1027 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6899 , A61K49/0002 , B82Y5/00 , C07K16/2851 , C07K2317/22 , C07K2317/35
摘要： The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
摘要翻译： 本发明涉及肿瘤相关巨噬细胞（TAM）的活性和特征。 特别地，针对TAM的标记提供免疫球蛋白单可变结构域，以及使用其免疫球蛋白单可变结构域用于肿瘤细胞的体内成像以及癌症诊断和治疗。
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公开(公告)号：US09101674B2
公开(公告)日：2015-08-11
申请号：US13480350
申请日：2012-05-24
申请人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
发明人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
CPC分类号： A61K51/1027 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6899 , A61K49/0002 , B82Y5/00 , C07K16/2851 , C07K2317/22 , C07K2317/35
摘要： The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
摘要翻译： 本发明涉及肿瘤相关巨噬细胞（TAM）的活性和特征。 特别地，针对TAM的标记提供免疫球蛋白单可变结构域，以及使用其免疫球蛋白单可变结构域用于肿瘤细胞的体内成像以及癌症诊断和治疗。
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公开(公告)号：US09771423B2
公开(公告)日：2017-09-26
申请号：US14240340
申请日：2012-08-22
申请人： Catherine Ghezzi , Daniel Fagret , Alexis Broisat , Nick Devoogdt , Tony Lahoutte , Serge Muydermans
发明人： Catherine Ghezzi , Daniel Fagret , Alexis Broisat , Nick Devoogdt , Tony Lahoutte , Serge Muydermans
IPC分类号： A61K39/395 , C07K16/28 , A61K51/10 , G01N33/68
CPC分类号： C07K16/2803 , A61K51/1027 , C07K16/2836 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/92 , C07K2317/94 , G01N33/6893
摘要： The present invention relates to nanobodies specifically directed against VCAM-1 and to their use in medical imaging and in diagnostic, prognostic and treatment methods.
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公开(公告)号：US20110262348A1
公开(公告)日：2011-10-27
申请号：US13065794
申请日：2011-03-29
申请人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
发明人： Kiavash Movahedi , Damya Laoui , Steve Schoonooghe , Geert Raes , Patrick De Baetselier , Jo Van Ginderachter , Nick Devoogdt , Tony Lahoutte
IPC分类号： A61K39/395 , A61P35/00 , A61K51/10 , C07K16/28 , C12N11/02
CPC分类号： A61K51/1027 , A61K47/6829 , A61K47/6849 , A61K47/6899 , B82Y5/00 , C07K16/2851 , C07K2317/22 , C07K2317/35
摘要： The present invention relates to the field of tumor growth and biology. The invention relates to activities and characteristics of tumor-associated macrophages, and uses of such for the diagnosis and treatment of cancer and tumor growth.
摘要翻译： 本发明涉及肿瘤生长和生物学领域。 本发明涉及肿瘤相关巨噬细胞的活性和特征，以及其用于诊断和治疗癌症和肿瘤生长的用途。
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公开(公告)号：US20140255303A1
公开(公告)日：2014-09-11
申请号：US14240340
申请日：2012-08-22
申请人： Catherine Ghezzi , Daniel Fagret , Alexis Broisat , Nick Devoogdt , Tony Lahoutte , Serge Muydermans
发明人： Catherine Ghezzi , Daniel Fagret , Alexis Broisat , Nick Devoogdt , Tony Lahoutte , Serge Muydermans
CPC分类号： C07K16/2803 , A61K51/1027 , C07K16/2836 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/92 , C07K2317/94 , G01N33/6893
摘要： The present invention relates to nanobodies specifically directed against VCAM-1 and to their use in medical imaging and in diagnostic, prognostic and treatment methods.
摘要翻译： 本发明涉及专门针对VCAM-1的纳米抗体及其在医学成像以及诊断，预后和治疗方法中的用途。
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