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8 条记录 (耗时 0.022 秒)

    Process
    4.
    发明授权
    Process 失效
    处理

    公开(公告)号：US08765065B2

    公开(公告)日：2014-07-01

    申请号：US13029198

    申请日：2011-02-17

    申请人： Luigi Martini ,  Philip Smith ,  Chi Leung Li ,  Ronald Raby

    发明人： Luigi Martini ,  Philip Smith ,  Chi Leung Li ,  Ronald Raby

    IPC分类号： B06B1/00

    CPC分类号： A61K9/2866 ,  A61K9/0004 ,  A61K9/2846 ,  A61K9/2886 ,  B23B37/00

    摘要： The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.

    摘要翻译： 本发明涉及一种使用超声波切割来制备口服递送装置的方法，所述口腔递送装置包括芯，所述芯包括由外部涂层覆盖的药物活性剂，所述外部涂层包括从所述装置的外部朝向芯部连通的一个或多个开口。

    PROCESS
    5.
    发明申请
    PROCESS 失效
    处理

    公开(公告)号：US20110131754A1

    公开(公告)日：2011-06-09

    申请号：US13029198

    申请日：2011-02-17

    申请人： Luigi MARTINI ,  Philip Smith ,  Chi Leung Li ,  Ronald Raby

    发明人： Luigi MARTINI ,  Philip Smith ,  Chi Leung Li ,  Ronald Raby

    IPC分类号： A47L9/00

    CPC分类号： A61K9/2866 ,  A61K9/0004 ,  A61K9/2846 ,  A61K9/2886 ,  B23B37/00

    摘要： The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.

    摘要翻译： 本发明涉及一种使用超声波切割来制备口服递送装置的方法，所述口腔递送装置包括芯，所述芯包括由外部涂层覆盖的药物活性剂，所述外部涂层包括从所述装置的外部朝向芯部连通的一个或多个开口。

    Process
    6.
    发明授权
    Process 有权
    处理

    公开(公告)号：US07923027B2

    公开(公告)日：2011-04-12

    申请号：US10416116

    申请日：2001-11-02

    申请人： Luigi Martini ,  Philip Smith ,  Chi Leung Li ,  Ronald Raby

    发明人： Luigi Martini ,  Philip Smith ,  Chi Leung Li ,  Ronald Raby

    IPC分类号： A61K9/24

    CPC分类号： A61K9/2866 ,  A61K9/0004 ,  A61K9/2846 ,  A61K9/2886 ,  B23B37/00

    摘要： The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.

    摘要翻译： 本发明涉及一种使用超声波切割来制备口服递送装置的方法，所述口腔递送装置包括芯，所述芯包括由外部涂层覆盖的药物活性剂，所述外部涂层包括从所述装置的外部朝向芯部连通的一个或多个开口。

    ORAL DOSAGE FORM FOR CONTROLLED DRUG RELEASE
    7.
    发明申请
    ORAL DOSAGE FORM FOR CONTROLLED DRUG RELEASE 有权
    用于控制药物释放的口服剂型

    公开(公告)号：US20110135695A1

    公开(公告)日：2011-06-09

    申请号：US12966323

    申请日：2010-12-13

    申请人： Chi Leung Li ,  Luigi Martini ,  Vincenzo Re ,  Helen Anne Willy

    发明人： Chi Leung Li ,  Luigi Martini ,  Vincenzo Re ,  Helen Anne Willy

    IPC分类号： A61K9/00 ,  A61K31/4439 ,  A61K31/522 ,  A61K31/4525 ,  A61K31/4178 ,  A61K31/137 ,  A61P3/10 ,  A61P31/22 ,  A61K9/28

    CPC分类号： A61K9/2072

    摘要： An oral dosage form comprising, (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core; characterised in that release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine.

    摘要翻译： 口服剂型，其包含（i）可侵蚀的核心，所述核心包含药学活性的弱碱或其药学上可接受的盐或溶剂合物; 和（ii）围绕所述芯的可侵蚀涂层，所述涂层包括基本上完全延伸穿过所述涂层但不穿透所述芯并且从使用环境与所述芯连通的一个或多个开口; 其特征在于药物活性弱碱或其药学上可接受的盐或溶剂合物从剂型的释放通过所述开口通过所述可侵蚀的核心的侵蚀和通过在预定pH条件下侵蚀所述可侵蚀的涂层而发生 ; 制备这种剂型的方法以及在药物中使用这种剂型。

    Oral dosage form for controlled drug release
    8.
    发明授权
    Oral dosage form for controlled drug release 有权
    用于控制药物释放的口服剂型

    公开(公告)号：US09144547B2

    公开(公告)日：2015-09-29

    申请号：US12966323

    申请日：2010-12-13

    申请人： Chi Leung Li ,  Luigi Martini ,  Vincenzo Re ,  Helen Anne Willy

    发明人： Chi Leung Li ,  Luigi Martini ,  Vincenzo Re ,  Helen Anne Willy

    IPC分类号： A61K9/20 ,  A61K9/24 ,  A61K9/28

    CPC分类号： A61K9/2072

    摘要： An oral dosage form comprising, (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core; characterized in that release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine.

    摘要翻译： 口服剂型，其包含（i）可侵蚀的核心，所述核心包含药学活性的弱碱或其药学上可接受的盐或溶剂合物; 和（ii）围绕所述芯的可侵蚀涂层，所述涂层包括基本上完全延伸穿过所述涂层但不穿透所述芯并且从使用环境与所述芯连通的一个或多个开口; 其特征在于药物活性弱碱或其药学上可接受的盐或溶剂合物从剂型的释放通过所述开口通过所述可侵蚀的核心的侵蚀和通过在预定pH条件下侵蚀所述可侵蚀的涂层而发生 ; 制备这种剂型的方法以及在药物中使用这种剂型。