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公开(公告)号:US20140030321A1
公开(公告)日:2014-01-30
申请号:US14111099
申请日:2012-04-12
申请人: Allen Ritter , Amy C. Williams , Lars Waldmann , Huamin Zhang
发明人: Allen Ritter , Amy C. Williams , Lars Waldmann , Huamin Zhang
IPC分类号: A61K38/08 , A61K9/10 , A61J1/00 , A61K31/704
CPC分类号: A61K38/08 , A61J1/00 , A61K9/0019 , A61K9/10 , A61K9/19 , A61K31/475 , A61K31/53 , A61K31/704 , A61K47/26 , A61K2300/00
摘要: The invention described herein pertains to a solid pharmaceutical composition comprising EC145 for reconstitution to provide a solution for intravenous injection, particularly to a lyophilized solid pharmaceutical composition comprising EC145 which has adequate stability for storage at ambient temperature and which is capable of redissolving in an aqueous diluent prior to administration, as well as a process for its manufacture, drug products comprising the composition and methods for using the composition for treating cancer.
摘要翻译: 本文描述的本发明涉及包含EC145的固体药物组合物,其用于重建以提供用于静脉内注射的溶液,特别是涉及包含EC145的冻干固体药物组合物,所述固体药物组合物在环境温度下具有足够的稳定性用于储存并且能够再溶解于水性稀释剂 在给药之前,以及其制备方法,包含组合物的药物产品和使用该组合物治疗癌症的方法。