公开(公告)号：US12161466B2

公开(公告)日：2024-12-10

申请号：US17446735

申请日：2021-09-02

Applicant: Allez Health Inc.

Inventor： Robert James Boock ,  Huashi Zhang

IPC: A61B5/1486 ,  A61B5/145 ,  C12N9/04 ,  C12Q1/00 ,  C25D7/06 ,  C25D9/02 ,  G01N27/327 ,  H01M4/02 ,  H01M4/04 ,  H01M4/1395 ,  H01M4/1399 ,  H01M4/96

Abstract: A working electrode for a subcutaneous sensor for use with a continuous biological monitor for a patient is disclosed. The working electrode includes a conductive substrate and a carbon-enzyme layer on the conductive substrate. The carbon-enzyme layer includes a polyurethane or silicone crosslinked with an acrylic polyol, and an enzyme fully entrapped by the polyurethane or silicone crosslinked with the acrylic polyol. The enzyme is selected according to a biological function to be monitored. The carbon-enzyme layer also includes a carbon material. The carbon-enzyme layer is electrically conductive and facilitates a generation of either peroxide or electrons within the carbon-enzyme layer responsive to reacting the enzyme with a target biologic from blood of the patient.

公开(公告)号：US20240404733A1

公开(公告)日：2024-12-05

申请号：US18797925

申请日：2024-08-08

Applicant: Allez Health Inc.

Inventor： Robert James Boock ,  Huashi Zhang ,  Wei Gu

IPC: H01B13/32 ,  A61B5/145 ,  B05D1/18

Abstract: Systems for manufacturing a working wire for a continuous biological sensor include an automated measurement system configured to measure, as an in-line process with a dipping station, a plurality of diameters along a length of a working wire. Systems also include a controller in communication with the automated measurement system, wherein the controller is configured to determine a thickness difference, the thickness difference being a difference between a thickness setpoint and an aggregate criteria for the plurality of diameters. The systems may include the dipping station, that is configured to hold a coating solution, and may include a robot positioned to move the fixture to the automated measurement system.

公开(公告)号：US12087469B2

公开(公告)日：2024-09-10

申请号：US17659267

申请日：2022-04-14

Applicant: Allez Health Inc.

Inventor： Robert James Boock ,  Huashi Zhang ,  Wei Gu

IPC: H01B13/32 ,  B05D1/18 ,  A61B5/145

CPC classification number: H01B13/328 ,  B05D1/18 ,  A61B5/14532

Abstract: Methods for coating a working wire for a continuous biological sensor include providing a plurality of wires in a fixture and dipping the plurality of wires into a coating solution according to parameters for a dipping process. A plurality of diameters is measured along a length of at least two coated wires of the plurality of wires in the fixture, using an automated measurement system, as in an in-line process. A controller that is in communication with the automated measurement system determines a thickness difference, the thickness difference being a difference between a thickness setpoint and an aggregate criteria for the plurality of diameters. The controller calculates adjusted parameters for the dipping process based on the thickness difference.