公开(公告)号：US20090182028A1

公开(公告)日：2009-07-16

申请号：US12295285

申请日：2007-03-29

申请人： Alois Jungbauer ,  Svjetlana Medjakovic ,  Alfred Zöchling

发明人： Alois Jungbauer ,  Svjetlana Medjakovic ,  Alfred Zöchling

IPC分类号： A61K31/404 ,  C07D405/06 ,  A61P35/00 ,  A61P25/28

CPC分类号： A61K31/404 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K31/353 ,  A61K31/366 ,  A61K36/31 ,  A23V2250/21 ,  A23V2200/308

摘要： The present invention provides a medicament comprising a chemical compound according to formula A: wherein R1 is hydrogen, fluorine, chlorine, bromine, hydroxy, mercapto, methoxy, ethoxy, acetoxy, methyl, ethyl, propyl, isopropyl, t-butyl, nitro, amin, N,N-dimethylaminoyl, N,N-diethyl-aminoyl; R2 is hydrogen, a C1-8-alkyl e.g. methyl, ethyl, propyl, isopropyl, butyl, t-butyl; an C1-8-acyl e.g. acetyl, propionyl; R3 is a C5-12-heterocyclic ring, e.g. furanyl, pyranyl, pyrrolyl, pyridinyl, pyrazolyl, thienyl, thiazolyl, indolyl or -0R4 ; R4 is a C5-C12-aromatic ring e.g. phenyl; unsubstituted or substituted in any position with fluorine, chlorine, bromine, methoxy, ethoxy, C1-8-carboxy; Z is OH or 0; and n is 0, 1, 2 or 3, and m is 0, 1, 2 or 3, and its use for the activation of the aryl hydro carbon receptor.

摘要翻译： 本发明提供一种药物，其包含式A化合物：其中R 1是氢，氟，氯，溴，羟基，巯基，甲氧基，乙氧基，乙酰氧基，甲基，乙基，丙基，异丙基，叔丁基，硝基， 氨基，N，N-二甲基氨基，N，N-二乙基 - 氨基; R 2是氢，C 1-8 - 烷基， 甲基，乙基，丙基，异丙基，丁基，叔丁基; 例如C 1-8酰基。 乙酰基，丙酰基; R3是C5-12-杂环，例如 呋喃基，吡喃基，吡咯基，吡啶基，吡唑基，噻吩基，噻唑基，吲哚基或-OR4; R4是C5-C12芳族环。 苯基; 在任何位置用氟，氯，溴，甲氧基，乙氧基，C1-8-羧基取代或取代; Z是OH或0; 并且n为0,1,2或3，m为0,1,2或3，并且其用于活化芳基氢碳受体。