公开(公告)号：US20170081668A1

公开(公告)日：2017-03-23

申请号：US15285949

申请日：2016-10-05

Applicant: Amgen Inc.

Inventor： Michael R. Comeau ,  David Fitzpatrick

IPC: C12N15/113 ,  A61K31/7088 ,  A61K39/395 ,  C07K16/24 ,  A61K45/06

CPC classification number: C12N15/1136 ,  A61K31/7088 ,  A61K38/1793 ,  A61K38/2046 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/24 ,  C12N2310/11 ,  C12N2310/14

Abstract: The invention provides methods and compositions for reducing or preventing fibrosis in a subject suffering from a fibrotic disorder by administering a therapeutically effective amount of at least one antagonist to the cytokine thymic stromal lymphopoietin to the subject. In one embodiment, the methods and compositions further comprise administering at least one additional antagonist to an additional profibrotic cytokine, growth factor or chemokine.

公开(公告)号：US20160251443A1

公开(公告)日：2016-09-01

申请号：US15058738

申请日：2016-03-02

Applicant: KIRIN-AMGEN, INC.

Inventor： Joel E. Tocker ,  Jacques J. Peschon ,  David Fitzpatrick ,  James F. Smothers ,  Christopher Mehlin ,  Ai Ching Lim

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.

Abstract translation: 本发明涉及IL-17受体A（IL-17RA或IL-17R）抗原结合蛋白，例如抗体，编码所述抗原结合蛋白的多核苷酸序列，以及用于诊断和治疗IL-17受体介导的疾病的组合物和方法 一种或多种IL-17配体的活化。 本发明涉及鉴定IL-17受体A（IL-17RA或IL-17R）上的中和决定簇和与之结合的抗体。 本发明的方面还包括与本文所述的IL-17RA中和抗体竞争结合的抗体。

公开(公告)号：US20190203209A1

公开(公告)日：2019-07-04

申请号：US16356807

申请日：2019-03-18

Applicant: Amgen Inc.

Inventor： Michael R. Comeau ,  David Fitzpatrick

IPC: C12N15/113 ,  C07K16/24 ,  A61K45/06 ,  A61K39/395 ,  A61K38/17 ,  A61K31/7088 ,  A61K38/20

CPC classification number: C12N15/1136 ,  A61K31/7088 ,  A61K38/1793 ,  A61K38/2046 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/24 ,  C12N2310/11 ,  C12N2310/14

Abstract: The invention provides methods and compositions for reducing or preventing fibrosis in a subject suffering from a fibrotic disorder by administering a therapeutically effective amount of at least one antagonist to the cytokine thymic stromal lymphopoietin to the subject. In one embodiment, the methods and compositions further comprise administering at least one additional antagonist to an additional profibrotic cytokine, growth factor or chemokine.

公开(公告)号：US20140356355A1

公开(公告)日：2014-12-04

申请号：US14304472

申请日：2014-06-13

Applicant: Amgen Inc.

Inventor： Joel E. Tocker ,  Jacques J. Peschon ,  David Fitzpatrick ,  James F. Smothers ,  Christopher Mehlin ,  Ai Ching Lim

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.

Abstract translation: 本发明涉及IL-17受体A（IL-17RA或IL-17R）抗原结合蛋白，例如抗体，编码所述抗原结合蛋白的多核苷酸序列，以及用于诊断和治疗IL-17受体介导的疾病的组合物和方法 一种或多种IL-17配体的活化。 本发明涉及鉴定IL-17受体A（IL-17RA或IL-17R）上的中和决定簇和与之结合的抗体。 本发明的方面还包括与本文所述的IL-17RA中和抗体竞争结合的抗体。