公开(公告)号：US20200071393A1

公开(公告)日：2020-03-05

申请号：US16406811

申请日：2019-05-08

申请人： Amgen Inc.

发明人： Michael R. Comeau ,  James F. Smothers ,  Bo-Rin P. Yoon ,  Christopher Mehlin

IPC分类号： C07K16/24

摘要： The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

公开(公告)号：US20150031870A1

公开(公告)日：2015-01-29

申请号：US14487932

申请日：2014-09-16

申请人： Amgen Inc.

发明人： SIMON MARK JACKSON ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC分类号： C07K16/40

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US08871914B2

公开(公告)日：2014-10-28

申请号：US14261063

申请日：2014-04-24

申请人： Amgen, Inc.

发明人： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC分类号： C07K16/40 ,  C07K16/00 ,  C12N15/113

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US08829165B2

公开(公告)日：2014-09-09

申请号：US13860016

申请日：2013-04-10

申请人： Amgen Inc.

发明人： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC分类号： A61K39/395 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

摘要翻译： 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。

公开(公告)号：US20140235830A1

公开(公告)日：2014-08-21

申请号：US14260975

申请日：2014-04-24

申请人： Amgen, Inc.

发明人： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC分类号： C07K16/40

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20160152700A1

公开(公告)日：2016-06-02

申请号：US15014828

申请日：2016-02-03

申请人： AMGEN INC.

发明人： Michael R. Comeau ,  James F. Smothers ,  Bo-Rin P. Yoon ,  Christopher Mehlin

IPC分类号： C07K16/24

CPC分类号： C07K16/24 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

摘要翻译： 本公开提供了与抗人结合蛋白相关的组合物和方法，其结合人胸腺基质淋巴细胞生成素（TSLP），包括抗体。 在具体实施方案中，本公开提供完全人，人源化和嵌合抗TSLP抗体及其抗体的衍生物。 本公开进一步提供编码此类抗体和抗体片段及衍生物的核酸，以及制备和使用此类抗体的方法，包括治疗和预防TSLP相关炎症和纤维化病症的方法。

公开(公告)号：US20140228547A1

公开(公告)日：2014-08-14

申请号：US14261065

申请日：2014-04-24

申请人： Amgen, Inc.

发明人： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC分类号： C07K16/40

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US10287348B2

公开(公告)日：2019-05-14

申请号：US15014828

申请日：2016-02-03

申请人： AMGEN INC.

发明人： Michael R. Comeau ,  James F. Smothers ,  Bo-Rin P. Yoon ,  Christopher Mehlin

IPC分类号： A61K39/00 ,  C07K16/24 ,  A61K39/395

摘要： The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

公开(公告)号：US08981064B2

公开(公告)日：2015-03-17

申请号：US14459743

申请日：2014-08-14

申请人： Amgen Inc.

发明人： Simon Mark Jackson ,  Bei Shan ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC分类号： C07K16/00 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

摘要翻译： 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。

公开(公告)号：US20140357851A1

公开(公告)日：2014-12-04

申请号：US14459787

申请日：2014-08-14

申请人： Amgen Inc.

发明人： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wenyan Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC分类号： C07K16/40

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.