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公开(公告)号：US20200147550A1
公开(公告)日：2020-05-14
申请号：US16743728
申请日：2020-01-15
Applicant: AMGEN INC.
Inventor： Eva Gefroh , Randolph W. Schweickart , Krista Petty , Gregory Frank , Christine Salstrom Terpsma , Arthur C, Hewig, III , Joseph Edward Shultz
Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
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公开(公告)号：US20170157566A1
公开(公告)日：2017-06-08
申请号：US15302762
申请日：2015-05-13
Applicant: AMGEN INC.
Inventor： Eva Gefroh , Randolph W. Schweickart , Krista Petty , Gregory Frank , Christine Salstrom Terpsma , Arthur C. Hewig, III , Joseph Edward Shultz
Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
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公开(公告)号：US11786866B2
公开(公告)日：2023-10-17
申请号：US17362282
申请日：2021-06-29
Applicant: AMGEN INC.
Inventor： Eva Gefroh , Randolph W. Schweickart , Krista Petty , Gregory Frank , Christine Salstrom Terpsma , Arthur C. Hewig, III , Joseph Edward Shultz
CPC classification number: B01D61/22 , B01D61/145 , B01D61/146 , B01D61/18 , C07K1/34 , B01D2311/04 , B01D2311/06 , B01D2313/18 , B01D2313/243 , B01D2315/10 , B01D2311/04 , B01D2311/2626 , B01D2311/2649 , B01D2311/06 , B01D2311/16
Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
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Patent Agency Ranking
公开(公告)号：US09371554B2
公开(公告)日：2016-06-21
申请号：US14365496
申请日：2012-12-14
Applicant: Amgen Inc.
Inventor： Thomas M McNerney , Krista Petty , Anne C Thomas , Xiaoyang Zhao
Abstract: The present invention relates to a method for harvesting recombinant proteins from mammalian cell culture fluid. The method makes use of cationic polymers, non-ionic polymers and non-ionic surfactants.
Abstract translation: 本发明涉及从哺乳动物细胞培养液中收获重组蛋白的方法。 该方法利用阳离子聚合物，非离子聚合物和非离子表面活性剂。
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公开(公告)号：US20210339196A1
公开(公告)日：2021-11-04
申请号：US17362282
申请日：2021-06-29
Applicant: AMGEN INC.
Inventor： Eva Gefroh , Randolph W. Schweickart , Krista Petty , Gregory Frank , Christine Salstrom Terpsma , Arthur C. Hewig, III , Joseph Edward Shultz
Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
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公开(公告)号：US11077404B2
公开(公告)日：2021-08-03
申请号：US16743728
申请日：2020-01-15
Applicant: AMGEN INC.
Inventor： Eva Gefroh , Randolph W. Schweickart , Krista Petty , Gregory Frank , Christine Salstrom Terpsma , Arthur C. Hewig, III , Joseph Edward Shultz
Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
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公开(公告)号：US10583397B2
公开(公告)日：2020-03-10
申请号：US15302762
申请日：2015-05-13
Applicant: AMGEN INC.
Inventor： Eva Gefroh , Randolph W. Schweickart , Krista Petty , Gregory Frank , Christine Salstrom Terpsma , Arthur C. Hewig, III , Joseph Edward Shultz
Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.
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公开(公告)号：US20150004646A1
公开(公告)日：2015-01-01
申请号：US14365496
申请日：2012-12-14
Applicant: Amgen Inc.
Inventor： Thomas M. McNerney , Krista Petty , Anne C Thomas , Xiaoyang Zhao
IPC: C12P21/00
Abstract: The present invention relates to a method for harvesting recombinant proteins from mammalian cell culture fluid. The method makes use of cationic polymers, non-ionic polymers and non-ionic surfactants.
Abstract translation: 本发明涉及从哺乳动物细胞培养液中收获重组蛋白的方法。 该方法利用阳离子聚合物，非离子聚合物和非离子表面活性剂。
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