公开(公告)号：US20220372071A1

公开(公告)日：2022-11-24

申请号：US17773892

申请日：2020-11-04

Applicant: AMGEN INC.

Inventor： Malhar R. AMBHAIKAR ,  Luis DIAZ ,  Natalia R. GOMEZ ,  Benjamin J. TILLOTSON

IPC: C07K1/18 ,  C07K16/46 ,  B01D15/36 ,  B01D15/42 ,  B01D15/38 ,  B01D61/14

Abstract: The invention relates to methods for removal of low isoelectric point product-related impurities during cation exchange purification operations.

公开(公告)号：US20220119526A1

公开(公告)日：2022-04-21

申请号：US17424547

申请日：2020-01-27

Applicant: Amgen Inc.

Inventor： Subramanian GUHAN ,  Malhar R. AMBHAIKAR ,  Vincent CHAI ,  Sai Chakradhar PADALA ,  Nitin RATHORE ,  Zane SAREMI ,  Kenneth SHOEMAKER ,  Benjamin J. TILLOTSON ,  Balakumar THANGARAJ ,  Philip CLARK ,  Ashish SHARMA ,  Hann-Chung WONG ,  John E. THORUP

IPC: C07K16/28 ,  C07K1/36 ,  A61K47/26

Abstract: A biologics manufacturing process that connects the drug substance and drug product processes into an integrated, continuous process.