公开(公告)号：US20220089756A1

公开(公告)日：2022-03-24

申请号：US17053728

申请日：2019-05-08

Applicant: Amgen Inc.

Inventor： John K. KAWOOYA ,  Alex W. JACOBITZ ,  Christopher MOHR ,  Stephen SMITH ,  Kevin GRAHAM ,  Ray Lieh Yoon LOW ,  Oliver THIEL ,  Dante ROMANINI ,  Victoria WAGNER ,  Neeraj J. AGRAWAL

IPC: C07K16/28 ,  C07K16/46

Abstract: The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.